Opposition Filed Opposition filed by Generics (UK) Ltd, Generics (UK) Ltd EP Register Verified

PHOSPHOROUS DERIVATIVES AS KINASE INHIBITORS

Publication No. EP2300013

•

App No. EP09751617

•

Filed by Takeda Pharmaceutical Company Limited

•

Filed on 2009-05-21

•

Issued/Published on 2024-11-13

Official EPO Register

Publication No. EP2300013 A1

Application No. EP09751617 Filed: 2009-05-21

Grant Date 2024-11-13 Mention of grant

Active Oppositions 3 Active EPO Oppositions

Patent Abstract / Summary

Patent abstract is being processed or was not provided in English by the publishing office.

IPC Classifications

A61K31/505, A61K31/513

Priority Claims

US 20080137490P Date: 2008-07-31

US 20080188796P Date: 2008-08-13

US 20080128317P Date: 2008-05-21

US 20080192938P Date: 2008-09-23

US 20080192964P Date: 2008-09-23

US 20080137490 Date: 2008-07-31

US 20080188796 Date: 2008-08-13

US 20080128317 Date: 2008-05-21

US 20080192938 Date: 2008-09-23

US 20080192964 Date: 2008-09-23

Designated Contracting States (35 EPC States)

Austria (AT)

Belgium (BE)

Bulgaria (BG)

Switzerland (CH)

Cyprus (CY)

Czech Republic (CZ)

Germany (DE)

Denmark (DK)

Estonia (EE)

Spain (ES)

Finland (FI)

France (FR)

United Kingdom (GB)

Greece (GR)

Croatia (HR)

Hungary (HU)

Ireland (IE)

Iceland (IS)

Italy (IT)

Liechtenstein (LI)

Lithuania (LT)

Luxembourg (LU)

Latvia (LV)

Monaco (MC)

North Macedonia (MK)

Malta (MT)

Netherlands (NL)

Norway (NO)

Poland (PL)

Portugal (PT)

Romania (RO)

Sweden (SE)

Slovenia (SI)

Slovakia (SK)

Turkey (TR)

Parties & Representation

Applicants

Takeda Pharmaceutical Company Limited

1-1, Doshomachi 4-chome, Chuo-ku

ARIAD PHARMACEUTICALS, INC.

40 Landsdowne Street, Cambridge, MA 02139

ARIAD Pharmaceuticals, Inc

26 Landsdowne Street, Cambridge, MA 02139

Inventors (12)

WANG, Yihan

45 Madison Avenue, Newton, MA 02460

HUANG, Wei-Sheng

8 Mohegan Road, Acton, MA 01720

LIU, Shuangying

4 Cedar Street 504, Wellesley, MA 02481

SHAKESPEARE, William, C.

2 Hubley Lane, Southborough, MA 01772

THOMAS, R., Mathew

419 Massapoag Avenue, Sharon, MA 02067

QI, Jiwei

1 Autumn Road, West Roxbury, MA 02132

LI, Feng

7 New Meadows Road, Winchester, MA 01890

ZHU, Xiaotian

137 Temple Street, Newton, MA 02465

KOHLMANN, Anna

58 Thornberry Road, Winchester, MA 01890

DALGARNO, David, C.

50 Crowninshield Road, Brookline, MA 02446

ROMERO, Jan, Antoinette, C.

33 Newbury Street 2, Somerville, MA 02144

ZOU, Dong

26 Minuteman Drive, Concord, MA 01742

Representatives / Agents

Carpmaels & Ransford LLP

One Southampton Row, London WC1B 5HA

Jones Day

Rechtsanwälte, Attorneys-at-Law, Patentanwälte, Prinzregentenstrasse 11

Duncan, Garreth Andrew, et al

D Young & Co LLP 120 Holborn London, EC1N 2DY

Vossius & Partner

Siebertstrasse 4, 81675 München

Elkington and Fife LLP

Prospect House, 8 Pembroke Road

Elkington & Fife LLP

Prospect House, 8 Pembroke Road

Cooke, Richard Spencer

Elkington and Fife LLP, Thavies Inn House

Key Procedural Dates

Request-For-Examination 2010-12-21

Patent-Maintained-As-Amended 2024-11-13

First-Examination-Report-Despatched 2014-04-14

Patent Oppositions

Official opposition proceedings filed against European Patent EP2300013 under EPC Article 99.

3 ACTIVE OPPONENTS

Opponent Company

Generics (UK) Ltd

Station Close, GB

Representative

Elkington and Fife LLP

Filing Date

2018-06-05

Opposition in Progress

Opponent Company

Generics (UK) Ltd

Station Close, GB

Representative

Elkington & Fife LLP

Filing Date

2018-06-05

Opposition in Progress

Opponent Company

Generics (UK) Ltd

Station Close, GB

Representative

Cooke, Richard Spencer

Filing Date

2018-06-05

Opposition in Progress

Legal Status & Event History

Official European Patent Office legal and procedural status changes recorded for this file.

169 Events Recorded

Date	Code	Event Description	Auth
2011-03-30	17P	REQUEST FOR EXAMINATION FILED	EP
2011-03-30	AK	DESIGNATED CONTRACTING STATES	EP
2011-03-30	AX	REQUEST FOR EXTENSION OF THE EUROPEAN PATENT	EP
2011-06-15	RIN1	INFORMATION ON INVENTOR PROVIDED BEFORE GRANT (CORRECTED)	EP
2011-08-24	DAX	REQUEST FOR EXTENSION OF THE EUROPEAN PATENT (DELETED)	EP
2012-09-12	RIC1	INFORMATION PROVIDED ON IPC CODE ASSIGNED BEFORE GRANT	EP
2012-09-12	A4	SUPPLEMENTARY SEARCH REPORT DRAWN UP AND DESPATCHED	EP
2014-05-14	17Q	FIRST EXAMINATION REPORT DESPATCHED	EP
2017-01-04	INTG	INTENTION TO GRANT ANNOUNCED	EP
2017-05-03	RAP1	PARTY DATA CHANGED (APPLICANT DATA CHANGED OR RIGHTS OF AN APPLICATION TRANSFERRED)	EP
2017-05-17	INTC	INTENTION TO GRANT ANNOUNCED (DELETED)	EP
2017-05-31	INTG	INTENTION TO GRANT ANNOUNCED	EP
2017-06-14	INTC	INTENTION TO GRANT ANNOUNCED (DELETED)	EP
2017-07-19	INTG	INTENTION TO GRANT ANNOUNCED	EP
2017-09-06	AK	DESIGNATED CONTRACTING STATES	EP
2017-09-06	REG	REFERENCE TO A NATIONAL CODE	EP
2017-09-15	REG	REFERENCE TO A NATIONAL CODE	EP
2017-10-12	REG	REFERENCE TO A NATIONAL CODE	EP
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2017-11-01	REG	REFERENCE TO A NATIONAL CODE	EP
2017-11-22	RAP2	PARTY DATA CHANGED (PATENT OWNER DATA CHANGED OR RIGHTS OF A PATENT TRANSFERRED)	EP
2017-12-07	REG	REFERENCE TO A NATIONAL CODE	EP
2017-12-04	REG	REFERENCE TO A NATIONAL CODE	EP
2017-10-31	REG	REFERENCE TO A NATIONAL CODE	EP
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2017-10-26	REG	REFERENCE TO A NATIONAL CODE	EP
2018-07-11	26	OPPOSITION FILED	EP
2018-11-12	REG	REFERENCE TO A NATIONAL CODE	EP
2018-12-26	R26	OPPOSITION FILED (CORRECTED)	EP
2019-05-27	REG	REFERENCE TO A NATIONAL CODE	EP
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2020-08-03	APBQ	DATE OF RECEIPT OF STATEMENT OF GROUNDS OF APPEAL RECORDED	EP
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2020-01-03	APBM	APPEAL REFERENCE RECORDED	EP
2020-01-24	APAH	APPEAL REFERENCE MODIFIED	EP
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2017-08-04	GRAA	(EXPECTED) GRANT	EP
2017-06-22	GRAP	DESPATCH OF COMMUNICATION OF INTENTION TO GRANT A PATENT	EP
2017-05-12	GRAJ	INFORMATION RELATED TO DISAPPROVAL OF COMMUNICATION OF INTENTION TO GRANT BY THE APPLICANT OR RESUMPTION OF EXAMINATION PROCEEDINGS BY THE EPO DELETED	EP
2017-05-12	GRAL	INFORMATION RELATED TO PAYMENT OF FEE FOR PUBLISHING/PRINTING DELETED	EP
2017-04-26	GRAR	INFORMATION RELATED TO INTENTION TO GRANT A PATENT RECORDED	EP
2017-04-26	GRAS	GRANT FEE PAID	EP
2017-04-11	GRAJ	INFORMATION RELATED TO DISAPPROVAL OF COMMUNICATION OF INTENTION TO GRANT BY THE APPLICANT OR RESUMPTION OF EXAMINATION PROCEEDINGS BY THE EPO DELETED	EP
2016-12-06	GRAP	DESPATCH OF COMMUNICATION OF INTENTION TO GRANT A PATENT	EP
2011-02-25	PUAI	PUBLIC REFERENCE MADE UNDER ARTICLE 153(3) EPC TO A PUBLISHED INTERNATIONAL APPLICATION THAT HAS ENTERED THE EUROPEAN PHASE	EP
2017-08-04	STAA	INFORMATION ON THE STATUS OF AN EP PATENT APPLICATION OR GRANTED EP PATENT	EP
2021-08-16	REG	REFERENCE TO A NATIONAL CODE	EP
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2019-10-16	PLCK	COMMUNICATION DESPATCHED THAT OPPOSITION WAS REJECTED	EP
2018-11-23	PLAB	OPPOSITION DATA, OPPONENT'S DATA OR THAT OF THE OPPONENT'S REPRESENTATIVE MODIFIED	EP
2018-10-30	PLBB	REPLY OF PATENT PROPRIETOR TO NOTICE(S) OF OPPOSITION RECEIVED	EP
2018-06-18	PLAX	NOTICE OF OPPOSITION AND REQUEST TO FILE OBSERVATION + TIME LIMIT SENT	EP
2018-06-08	PLBI	OPPOSITION FILED	EP
2017-06-22	STAA	INFORMATION ON THE STATUS OF AN EP PATENT APPLICATION OR GRANTED EP PATENT	EP
2017-05-12	STAA	INFORMATION ON THE STATUS OF AN EP PATENT APPLICATION OR GRANTED EP PATENT	EP
2017-04-26	STAA	INFORMATION ON THE STATUS OF AN EP PATENT APPLICATION OR GRANTED EP PATENT	EP
2017-04-11	STAA	INFORMATION ON THE STATUS OF AN EP PATENT APPLICATION OR GRANTED EP PATENT	EP
2016-12-06	STAA	INFORMATION ON THE STATUS OF AN EP PATENT APPLICATION OR GRANTED EP PATENT	EP
2021-12-02	REG	REFERENCE TO A NATIONAL CODE	EP
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2022-07-02	APAH	APPEAL REFERENCE MODIFIED	EP
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2022-12-12	APBU	APPEAL PROCEDURE CLOSED	EP
2023-02-08	PLAY	EXAMINATION REPORT IN OPPOSITION DESPATCHED + TIME LIMIT	EP
2023-04-21	PLBC	REPLY TO EXAMINATION REPORT IN OPPOSITION RECEIVED	EP
2023-05-26	REG	REFERENCE TO A NATIONAL CODE	EP
2023-06-28	P01	OPT-OUT OF THE COMPETENCE OF THE UNIFIED PATENT COURT (UPC) REGISTERED	EP
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2023-07-13	PLAY	EXAMINATION REPORT IN OPPOSITION DESPATCHED + TIME LIMIT	EP
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2024-10-11	PUAH	PATENT MAINTAINED IN AMENDED FORM	EP
2024-10-11	STAA	INFORMATION ON THE STATUS OF AN EP PATENT APPLICATION OR GRANTED EP PATENT	EP
2024-10-12	PLAO	INFORMATION DELETED RELATED TO DESPATCH OF COMMUNICATION THAT OPPOSITION IS REJECTED	EP
2024-11-13	REG	REFERENCE TO A NATIONAL CODE	EP
2024-11-13	27A	PATENT MAINTAINED IN AMENDED FORM	EP
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Patent & Non-Patent Citations

Cited documents and prior art referenced in search and examination reports.

29 Citations

Cited Patent Documents

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Non-Patent Scientific Literature (NPL)

GALKIN ET AL.: "Identification of NVP-TAE684, a potent, selective and efficacious Inhibitor of NPM-ALK", PNAS, vol. 104, no. 1, 2 January 2007 (2007-01-02), pages 270 - 275, XP002661293

BRUNING ET AL.: "Role of Brain Insulin Receptor in Control of Body Weight and Reproduction", SCIENCE, vol. 22, 22 September 2000 (2000-09-22), pages 2122 - 2125, XP055499036

KAHN ET AL.: "Loss of insulin signalling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction", MOLECULAR CELL, vol. 6, 2000, pages 87 - 97, XP055499037

KITAMURA ET AL.: "Insulin Receptor Knockout Mice", ANNU. REV. PHYSIOL., vol. 65, 2003, pages 313 - 332, XP055499041

CORTEZ ET AL.: "Common mechanisms of PIKK regulation", DNA REPAIR, vol. 8, 2009, pages 1004 - 1008, XP026446528

PICCALUGA ET AL.: "Imatinib mesylate in the treatment of hematologic malignancies", EXPERT OPIN. BIOL. THER., vol. 7, no. 10, 2007, pages 1597 - 1611, XP055499048

MASS: "The HER receptor family: a rich target for therapeutic development", INT. J. RADIATION ONCOLOGY BIOL. PHYS., vol. 58, 2004, pages 932 - 940, XP008060823

FABBRO ET AL.: "Protein kinases as targets for anticancer agents: from inhibitors to useful drugs", PHARMACOLOGY AND THERAPEUTICS, vol. 93, 2002, pages 79 - 98, XP002350189

FIAUD ET AL.: "Synthesis of Enantiopure 1-r-Aryl-2-c,5-t-diphenylphospholane oxides and boranes by Pd-Catalyzed C-P Bond Formation", EUR. J. ORG. CHEM., 2006, pages 650 - 656, XP055499101

KAMER ET AL.: "Wide Bite Angle Diphosphines: Xantphos Ligands in Transition Metal Complexes and Catalysis", ACC. CHEM. RES., vol. 34, 2001, pages 895 - 904, XP055499103

- GALKIN ET AL.: "Identification of NVP-TAE684, a potent, selective and efficacious Inhibitor of NPM-ALK", PNAS, vol. 104, no. 1, 2 January 2007 (2007-01-02), pages 270 - 275, XP002661293

- BRUNING ET AL.: "Role of Brain Insulin Receptor in Control of Body Weight and Reproduction", SCIENCE, vol. 22, 22 September 2000 (2000-09-22), pages 2122 - 2125, XP055499036

- KAHN ET AL.: "Loss of insulin signalling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction", MOLECULAR CELL, vol. 6, 2000, pages 87 - 97, XP055499037

- KITAMURA ET AL.: "Insulin Receptor Knockout Mice", ANNU. REV. PHYSIOL., vol. 65, 2003, pages 313 - 332, XP055499041

- CORTEZ ET AL.: "Common mechanisms of PIKK regulation", DNA REPAIR, vol. 8, 2009, pages 1004 - 1008, XP026446528

- PICCALUGA ET AL.: "Imatinib mesylate in the treatment of hematologic malignancies", EXPERT OPIN. BIOL. THER., vol. 7, no. 10, 2007, pages 1597 - 1611, XP055499048

- MASS: "The HER receptor family: a rich target for therapeutic development", INT. J. RADIATION ONCOLOGY BIOL. PHYS., vol. 58, 2004, pages 932 - 940, XP008060823

- FABBRO ET AL.: "Protein kinases as targets for anticancer agents: from inhibitors to useful drugs", PHARMACOLOGY AND THERAPEUTICS, vol. 93, 2002, pages 79 - 98, XP002350189

- FIAUD ET AL.: "Synthesis of Enantiopure 1-r-Aryl-2-c,5-t-diphenylphospholane oxides and boranes by Pd-Catalyzed C-P Bond Formation", EUR. J. ORG. CHEM., 2006, pages 650 - 656, XP055499101

- KAMER ET AL.: "Wide Bite Angle Diphosphines: Xantphos Ligands in Transition Metal Complexes and Catalysis", ACC. CHEM. RES., vol. 34, 2001, pages 895 - 904, XP055499103

Worldwide Patent Family

Related applications and patents in the same INPADOC worldwide family.

84 Family Members

Country	Publication Number	Kind	Publication Date	Action
EP	EP2300013A1	A1	2011-03-30	Espacenet
EP	EP2300013A4	A4	2012-09-12	Espacenet
EP	EP2300013B1	B1	2017-09-06	Espacenet
EP	EP2300013B2	B2	2024-11-13	Espacenet
AU	AU2009248923A1	A1	2009-11-26	Espacenet
AU	AU2009248923B2	B2	2015-01-29	Espacenet
BR	BRPI0908637A2	A2	2018-10-23	Espacenet
BR	BRPI0908637B1	B1	2020-11-17	Espacenet
BR	BRPI0908637B8	B8	2021-05-25	Espacenet
CA	CA2723961A1	A1	2009-11-26	Espacenet
CA	CA2723961C	C	2017-03-21	Espacenet
CN	CN102105150A	A	2011-06-22	Espacenet
CN	CN102105150B	B	2014-03-12	Espacenet
CY	CY1119534T1	T1	2018-04-04	Espacenet
CY	CY2019027I1	I1	2019-11-27	Espacenet
CY	CY2019027I2	I2	2019-11-27	Espacenet
DK	DK2300013T3	T3	2017-12-04	Espacenet
DK	DK2300013T4	T4	2025-02-03	Espacenet
EA	EA201071339A1	A1	2011-06-30	Espacenet
EA	EA029131B1	B1	2018-02-28	Espacenet
EP	EP3210609A1	A1	2017-08-30	Espacenet
EP	EP4813391A2	A2	2026-09-30	Espacenet
ES	ES2645689T3	T3	2017-12-07	Espacenet
ES	ES2645689T5	T5	2025-06-24	Espacenet
FI	FI2300013T4	T4	2025-02-04	Espacenet
FI	FIC20190029I1	I1	2019-05-17	Espacenet
FR	FR19C1033I1	I1	2019-06-21	Espacenet
FR	FR19C1033I2	I2	2020-01-31	Espacenet
HK	HK1158497A1	A1	2012-07-20	Espacenet
HR	HRP20171534T1	T1	2018-01-26	Espacenet
HR	HRP20171534T8	T8	2018-08-24	Espacenet
HR	HRP20171534T4	T4	2025-02-14	Espacenet
HU	HUE035029T2	T2	2018-03-28	Espacenet
HU	HUS1900029I1	I1	2020-04-28	Espacenet
IL	IL208716B	B	2018-02-28	Espacenet
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Official File Inspection EPC Art. 128 Public Dossier

Complete European Patent Register Dossier (148 Total Documents)

The full inspection file for Application EP09751617 contains 148 total documents, including all notices of opposition, proprietor counter-statements, examination communications, third-party observations, and procedural forms. Below are all major recorded procedural filings and publication specifications.

Open 148-Doc Register Dossier

Dossier Filing

Date: 2024-01-02 Procedure: Opposition EPIDOSDORE2

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PHOSPHOROUS DERIVATIVES AS KINASE INHIBITORS

Patent Abstract / Summary

IPC Classifications

Priority Claims

Designated Contracting States (35 EPC States)

Parties & Representation

Applicants

Inventors (12)

Representatives / Agents

Key Procedural Dates

Patent Oppositions

Generics (UK) Ltd

Generics (UK) Ltd

Generics (UK) Ltd

Legal Status & Event History

Patent & Non-Patent Citations

Cited Patent Documents

Non-Patent Scientific Literature (NPL)

Worldwide Patent Family

Complete European Patent Register Dossier (148 Total Documents)

Recorded Filings & Patent Specifications

New European Patent Specification after Opposition (B2)

Official European Patent Register Full Dossier

European Patent Specification - Granted Patent (B1)

European Patent Application with Search Report (A1)

Deletion: Despatch of communication that opposition is rejected

Patent maintained (B2 publication)

New entry: Legal effect of interlocutory decision

New entry: Despatch of communication that the patent will be maintained as amended

Preparation for maintenance of the patent in an amended form

New entry: Despatch of interlocutory decision

Interlocutory decision in opposition

Deletion: Despatch of examination report in opposition + time limit

New entry: Despatch of examination report in opposition + time limit

New entry: Reply to examination report in opposition

Communication from the opposition division

New entry: Despatch of examination report in opposition + time limit

New entry: Decision (+date) in appeal procedure

Oral proceedings

Change: Appeal number

Change - applicant

Change: Date of oral proceedings

Deletion: Despatch of minutes of oral proceedings

New entry: Date of receipt of statement of grounds of an appeal

Change: Appeal number

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New entry: Date of receipt of notice of appeal

New entry: Despatch of minutes of oral proceedings

New entry: Despatch of communication that opposition is rejected

Oral proceedings

New entry: Date of oral proceedings

Change - opposition data/opponent's data or that of the opponent's representative

New entry: Reply of patent proprietor to notice(s) of opposition

Change - representative

Invitation to proprietor to file observations on the notice of opposition

New entry: Communication of a notice of opposition and request to file observations + time limit

Opposition filed

Change - applicant

(Expected) grant

New entry: Receipt of the translation of the claim(s)

New entry: Communication of intention to grant a patent

Change - representative

Deletion - Disapproval of the communication of intention to grant the patent by the applicant or resumption of examination proceedings by the EPO

Deletion: Payment of fee for publishing/printing

Deletion: Receipt of the translation of the claim(s)

New entry: Renewal fee paid

DISSAPPROVAL_OF_COMMUNICATION_OF_INTENTION_TO_GRANT_PATENT

Renewal fee payment

New entry: Information about intention to grant a patent

New entry: Payment of fee for grant

New entry: Payment of fee for publishing/printing

New entry: Receipt of the translation of the claim(s)

Intention to grant the patent

Deletion - Disapproval of the communication of intention to grant the patent by the applicant or resumption of examination proceedings by the EPO

Intention to grant the patent

DISSAPPROVAL_OF_COMMUNICATION_OF_INTENTION_TO_GRANT_PATENT

Change - divisional application(s)

Change - applicant

Intention to grant the patent

New entry: Communication of intention to grant a patent