Opposition rejected Opposition rejected, The patent has been granted, Grant of patent is intended, Examination is in progress EP Register Verified

Combinations of a muscarinic receptor antagonist and a beta-2 adrenoreceptor agonist

Publication No. EP2506844

•

App No. EP10781527

•

Filed by Glaxo Group Limited

•

Filed on 2010-11-29

•

Issued/Published on 2017-12-20

Official EPO Register

Publication No. EP2506844 A1

Application No. EP10781527 Filed: 2010-11-29

Grant Date 2017-12-20 Mention of grant

Active Oppositions 6 Active EPO Oppositions

Patent Abstract / Summary

Patent abstract is being processed or was not provided in English by the publishing office.

IPC Classifications

A61K31/138, A61K31/439, A61K45/06, A61P11/06, A61P11/08

Priority Claims

GB 20090021075 Date: 2009-12-01

Designated Contracting States (38 EPC States)

Albania (AL)

Austria (AT)

Belgium (BE)

Bulgaria (BG)

Switzerland (CH)

Cyprus (CY)

Czech Republic (CZ)

Germany (DE)

Denmark (DK)

Estonia (EE)

Spain (ES)

Finland (FI)

France (FR)

United Kingdom (GB)

Greece (GR)

Croatia (HR)

Hungary (HU)

Ireland (IE)

Iceland (IS)

Italy (IT)

Liechtenstein (LI)

Lithuania (LT)

Luxembourg (LU)

Latvia (LV)

Monaco (MC)

North Macedonia (MK)

Malta (MT)

Netherlands (NL)

Norway (NO)

Poland (PL)

Portugal (PT)

Romania (RO)

Serbia (RS)

Sweden (SE)

Slovenia (SI)

Slovakia (SK)

San Marino (SM)

Turkey (TR)

Parties & Representation

Applicants

Glaxo Group Limited

980 Great West Road, Brentford, Middlesex TW8 9GS

Inventors (6)

BAKER, Darrell

GlaxoSmithKline, Ironbridge Road

BRUCE, Mark

GlaxoSmithKline, Gunnels Wood Road

CRATER, Glenn

GlaxoSmithKline, Five Moore Drive

NOGA, Brian

c/o GlaxoSmithKline, Five Moore Drive

THOMAS, Marian

GlaxoSmithKline, Park Road

WIRE, Patrick

GlaxoSmithKline, Five Moore Drive

Representatives / Agents

Hoffmann Eitle

Patent- und Rechtsanwälte PartmbB, Arabellastraße 30

Fowler, Gavin James

GlaxoSmithKline, Global Patents (CN925.1)

Elkington and Fife LLP, et al

Prospect House, 8 Pembroke Road

Breuer, Markus

Sendlinger Straße 29, 80331 München

Gill Jennings & Every LLP, et al

The Broadgate Tower, 20 Primrose Street

Elkington & Fife LLP, et al

Prospect House, 8 Pembroke Road

Henkel, Breuer & Partner

Patentanwälte, Brienner Strasse 1

Gillard, Richard Edward, et al

Elkington and Fife LLP, Thavies Inn House

Key Procedural Dates

Request-For-Examination 2012-05-25

First-Examination-Report-Despatched 2016-03-04

Patent Oppositions

Official opposition proceedings filed against European Patent EP2506844 under EPC Article 99.

6 ACTIVE OPPONENTS

Opponent Company

Teva UK Limited

Ridings Point, GB

Representative

Elkington and Fife LLP, et al

Filing Date

2018-09-17

Opposition in Progress

Opponent Company

Breuer, Markus

Henkel, Breuer & Partner, DE

Representative

Breuer, Markus

Filing Date

2018-09-19

Opposition in Progress

Opponent Company

Sima Patent ve Lisanslama Hizmetleri Ltd.Sti.

Yildiz Teknik Üniversitesi, TR

Representative

Gill Jennings & Every LLP, et al

Filing Date

2018-09-20

Opposition in Progress

Opponent Company

Teva UK Limited

Ridings Point, GB

Representative

Elkington & Fife LLP, et al

Filing Date

2018-09-17

Opposition in Progress

Opponent Company

Breuer, Markus

Henkel, Breuer & Partner, DE

Representative

Henkel, Breuer & Partner

Filing Date

2018-09-19

Opposition in Progress

Opponent Company

Teva UK Limited

Ridings Point, GB

Representative

Gillard, Richard Edward, et al

Filing Date

2018-09-17

Opposition in Progress

Legal Status & Event History

Official European Patent Office legal and procedural status changes recorded for this file.

144 Events Recorded

Date	Code	Event Description	Auth
2012-10-10	AK	DESIGNATED CONTRACTING STATES	EP
2012-10-10	17P	REQUEST FOR EXAMINATION FILED	EP
2012-10-10	AX	REQUEST FOR EXTENSION OF THE EUROPEAN PATENT	EP
2013-05-01	RAP1	PARTY DATA CHANGED (APPLICANT DATA CHANGED OR RIGHTS OF AN APPLICATION TRANSFERRED)	EP
2013-06-07	REG	REFERENCE TO A NATIONAL CODE	EP
2016-04-06	17Q	FIRST EXAMINATION REPORT DESPATCHED	EP
2017-08-16	INTG	INTENTION TO GRANT ANNOUNCED	EP
2017-12-06	INTC	INTENTION TO GRANT ANNOUNCED (DELETED)	EP
2017-12-13	INTG	INTENTION TO GRANT ANNOUNCED	EP
2017-12-20	AX	REQUEST FOR EXTENSION OF THE EUROPEAN PATENT	EP
2017-12-20	AK	DESIGNATED CONTRACTING STATES	EP
2017-12-20	REG	REFERENCE TO A NATIONAL CODE	EP
2018-01-10	REG	REFERENCE TO A NATIONAL CODE	EP
2017-12-29	REG	REFERENCE TO A NATIONAL CODE	EP
2018-01-18	REG	REFERENCE TO A NATIONAL CODE	EP
2018-01-15	REG	REFERENCE TO A NATIONAL CODE	EP
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2017-10-31	GRAJ	INFORMATION RELATED TO DISAPPROVAL OF COMMUNICATION OF INTENTION TO GRANT BY THE APPLICANT OR RESUMPTION OF EXAMINATION PROCEEDINGS BY THE EPO DELETED	EP
2017-10-31	GRAL	INFORMATION RELATED TO PAYMENT OF FEE FOR PUBLISHING/PRINTING DELETED	EP
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2020-12-11	REG	REFERENCE TO A NATIONAL CODE	EP
2012-09-07	PUAI	PUBLIC REFERENCE MADE UNDER ARTICLE 153(3) EPC TO A PUBLISHED INTERNATIONAL APPLICATION THAT HAS ENTERED THE EUROPEAN PHASE	EP
2017-11-17	STAA	INFORMATION ON THE STATUS OF AN EP PATENT APPLICATION OR GRANTED EP PATENT	EP
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2018-12-07	PLAB	OPPOSITION DATA, OPPONENT'S DATA OR THAT OF THE OPPONENT'S REPRESENTATIVE MODIFIED	EP
2018-10-16	PLAX	NOTICE OF OPPOSITION AND REQUEST TO FILE OBSERVATION + TIME LIMIT SENT	EP
2018-09-21	PLBI	OPPOSITION FILED	EP
2017-11-10	STAA	INFORMATION ON THE STATUS OF AN EP PATENT APPLICATION OR GRANTED EP PATENT	EP
2017-10-31	STAA	INFORMATION ON THE STATUS OF AN EP PATENT APPLICATION OR GRANTED EP PATENT	EP
2017-07-16	STAA	INFORMATION ON THE STATUS OF AN EP PATENT APPLICATION OR GRANTED EP PATENT	EP
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Patent & Non-Patent Citations

Cited documents and prior art referenced in search and examination reports.

31 Citations

Cited Patent Documents

WO2010097114 2010-09-02

Espacenet

WO2010097115 2010-09-02

Espacenet

WO03024439 2003-03-27

Espacenet

WO2005104745 2005-11-10

Espacenet

WO2005115463 2005-12-08

Espacenet

WO2005037280 2005-04-28

Espacenet

WO2009090010

Espacenet

US7488827

Espacenet

Non-Patent Scientific Literature (NPL)

- D. LAINE ET AL.: "Discovery of Novel 1-Azoniabicyclo[2.2.2]octane Muscarinic Acetylcholine Receptor Antagonists", JOURNAL OF MEDICINAL CHEMISTRY, vol. 52, no. 8, 2009, pages 2493 - 2505, XP002621866

- EMA: "ANORO®", SUMMARY OF PRODUCT CHARACTERISTICS (SMPC) EUROPEAN MEDICINES AGENCY

- SCHELFHOUT ET AL.: "Activity of aclidinium bromide, a new long-acting muscarinic antagonist: a phase I study", BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, vol. 69, no. 5, 12 April 2010 (2010-04-12), pages 458 - 464, XP009504914

- ANONYMOUS: "Eklira®", ANNEX I: SUMMARY OF PRODUCT CHARACTERISTICS (SMPC) EUROPEAN MEDICINES AGENCY, 30 July 2012 (2012-07-30), XP002780227

- FDA: "FDA approval labelling for Tudorza®", HIGHLIGHTS OF PRESCRIBING INFORMATION US FOOD AND DRUG ADMINISTRATION, XP002780228

- P. JONES: "Aclidinium Bromide Twice Daily for the Treatment of Chronic Obstructive Pulmonary Disease: A Review", ADVANCED THERAPEUTICS, vol. 30, no. 4, April 2013 (2013-04-01), pages 354 - 368, XP002780229

- GOLD TEAMS: "The global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease", EXECUTIVE SUMMARY GLOBAL INITIATIVE FOR CHRONIC OBSTRUCTIVE LUNG DISEASE, 2009, XP055520517

- GINA TEAMS: "The global strategy for asthma management and prevention", GLOBAL INITIATIVE FOR ASTHMA, 2009, XP055520525

- P. J. BARNES ET AL.: "The Pharmacological Properties of Tiotropium", CHEST, vol. 117, no. 2, February 2000 (2000-02-01), pages 63S - 66S, XP055520530

- X.M. ZENG ET AL.: "Particulate interactions in dry powder formulations for inhalation", 2001, TAYLOR & FRANCIS, London, pages: 156 - 159, XP055520504

- PETER J. BARNES: "ABC OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE: FUTURE TREATMENTS", BMJ, vol. 333, 29 July 2006 (2006-07-29), pages 246 - 248, XP009083676

- CAZZOLA ET AL.: "The effective treatment of COPD: Anticholinergics and what else?", DRUG DISCOVERY TODAY: THERAPEUTIC STRATEGIES, vol. 3, no. 3, 2006, pages 277 - 286, XP005777432

- CAZZOLA M; ET AL: "Ultra long-acting beta2-agonists in development for asthma and chronic obstructive pulmonary disease", EXPERT OPIN. INVESTIG. DRUGS, vol. 14, no. 7, 2005, pages 775 - 783, XP003026042

- DRAMANE I LAINÉ ET AL.: "Discovery of Novel 1-Azoniabicyclo[2.2.2]octane Muscarinic Acetylcholine Receptor Antagonists", J. MED. CHEM., vol. 52, 2009, pages 2493 - 2505, XP002691510

- DATABASE PubChem COMPOUND 26 October 2006 (2006-10-26), ANONYMOUS : "Umeclidinium bromide | C29H34BrNO2", XP055943090, Database accession no. CID 11519069

- DATABASE Pubchem COMPOUND 25 October 2006 (2006-10-25), ANONYMOUS : "Vilanterol | C24H33Cl2NO5", XP055943094, Database accession no. CID 10184665

- GROSS, N.J.: "Anticholinergic agents in asthma and COPD", EUROPEAN JOURNAL OF PHARMACOLOGY, ELSEVIER SCIENCE, NL, vol. 533, no. 1-3, 8 March 2006 (2006-03-08), NL , pages 36 - 39, XP028028951, ISSN: 0014-2999, DOI: 10.1016/j.ejphar.2005.12.072

- ANONYMOUS: "History of Changes for Study: NCT00976144 - Safety, Tolerability, Pharmacokinetic and Pharmacodynamic Effects of GSK573719 (LAMA) and GW642444 (LABA)Administered Individually and Concurrently in Healthy Japanese Subjects (DB2113208)", CLINICALTRIALS.GOV, 11 September 2009 (2009-09-11), pages 1 - 5, XP055943101, Retrieved from the Internet <URL:https://clinicaltrials.gov/ct2/history/NCT00976144?A=1&B=1&C=merged#StudyPageTop> [retrieved on 20220715]

- M CAZZOLA, M G MATERA: "Novel long-acting bronchodilators for COPD and asthma", BRITISH JOURNAL OF PHARMACOLOGY, NATURE PUB. GROUP, ETC., vol. 155, no. 3, 1 October 2008 (2008-10-01), pages 291 - 299, XP055104106, ISSN: 00071188, DOI: 10.1038/bjp.2008.284

- CAZZOLA M: "Current opinion: Pharmacological approaches in asthma and COPD", BREATHE, vol. 6, no. 1, 1 September 2009 (2009-09-01), pages 24 - 35, XP055943110, ISSN: 1810-6838, DOI: 10.1183/18106838.0601.024

- DRAMANE I. LAINEÌ, BRENT MCCLELAND, SONIA THOMAS, CHRISTOPHER NEIPP, BRIAN UNDERWOOD, JEREMY DUFOUR, KATHERINE L. WIDDOWSON, MICHA: "Discovery of Novel 1-Azoniabicyclo[2.2.2]octane Muscarinic Acetylcholine Receptor Antagonists", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 58, no. 8, 23 April 2009 (2009-04-23), US , pages 2493 - 2505, XP002691510, ISSN: 0022-2623, DOI: 10.1021/jm801601v

- GUPTA ABHAY, HAMAD MAZEN L., TAWAKKUL MOBIN, SAYEED VILAYAT A., KHAN MANSOOR A.: "Difference in the Lubrication Efficiency of Bovine and Vegetable-Derived Magnesium Stearate During Tabletting", AAPS PHARMSCITECH, vol. 10, no. 2, 2 June 2009 (2009-06-02), pages 500 - 504, XP055943118, DOI: 10.1208/s12249-009-9229-y

- M CAZZOLA, ET AL: "Emerging inhaled bronchodilators: an update", EUR RESPIR J, vol. 34, 1 January 2009 (2009-01-01), pages 757 - 769, XP055697899, DOI: 10.1183/09031936.00013109

Worldwide Patent Family

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112 Family Members

Country	Publication Number	Kind	Publication Date	Action
EP	EP2506844A1	A1	2012-10-10	Espacenet
EP	EP2506844B1	B1	2017-12-20	Espacenet
AU	AU2010326798A1	A1	2012-06-21	Espacenet
AU	AU2010326798B2	B2	2014-08-07	Espacenet
AU	AU2014204459A1	A1	2014-07-31	Espacenet
AU	AU2014204459B2	B2	2016-08-25	Espacenet
AU	AU2016262698A1	A1	2016-12-15	Espacenet
AU	AU2016262698B2	B2	2018-10-25	Espacenet
AU	AU2017238392A1	A1	2018-09-27	Espacenet
AU	AU2018282427A1	A1	2019-01-17	Espacenet
AU	AU2018282427B2	B2	2021-04-01	Espacenet
AU	AU2018282427C1	C1	2022-06-30	Espacenet
AU	AU2021204302A1	A1	2021-07-22	Espacenet
AU	AU2023219901A1	A1	2023-09-14	Espacenet
BR	BR112012012925A2	A2	2016-08-16	Espacenet
BR	BR112018069147A2	A2	2019-01-22	Espacenet
CA	CA2781487A1	A1	2011-06-09	Espacenet
CA	CA2781487C	C	2018-10-16	Espacenet
CA	CA3018345A1	A1	2017-09-28	Espacenet
CL	CL2012001432A1	A1	2012-10-05	Espacenet
CN	CN102724974A	A	2012-10-10	Espacenet
CN	CN107412229A	A	2017-12-01	Espacenet
CN	CN108778288A	A	2018-11-09	Espacenet
CO	CO6541613A2	A2	2012-10-16	Espacenet
CR	CR20120265A	A	2012-08-14	Espacenet
CY	CY1120058T1	T1	2018-09-05	Espacenet
CY	CY2018017I1	I1	2018-09-05	Espacenet
CY	CY2018017I2	I2	2018-09-05	Espacenet
DK	DK2506844T3	T3	2018-02-05	Espacenet
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DO	DOP2012000148A	A	2012-07-31	Espacenet
EA	EA201290266A1	A1	2013-02-28	Espacenet
EA	EA023839B1	B1	2016-07-29	Espacenet
EP	EP3335707A1	A1	2018-06-20	Espacenet
EP	EP3335707B1	B1	2024-04-17	Espacenet
EP	EP3432892A1	A1	2019-01-30	Espacenet
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ES	ES2659330T3	T3	2018-03-14	Espacenet
ES	ES2979060T3	T3	2024-09-24	Espacenet
FI	FI3335707T3	T3	2024-07-05	Espacenet
FI	FIC20180019I1	I1	2018-05-30	Espacenet
FR	FR18C1022I1	I1	2018-07-13	Espacenet
FR	FR18C1022I2	I2	2020-03-20	Espacenet
GB	GB0921075D0	D0	2010-01-13	Espacenet
HK	HK1249407A1	A1	2018-11-02	Espacenet
HR	HRP20180312T1	T1	2018-03-23	Espacenet
HR	HRP20240688T1	T1	2024-08-30	Espacenet
HU	HUE036216T2	T2	2018-06-28	Espacenet
HU	HUE066359T2	T2	2024-07-28	Espacenet
HU	HUS1800027I1	I1	2018-08-28	Espacenet
IL	IL219893A	A	2017-01-31	Espacenet
JP	JP2013512270A	A	2013-04-11	Espacenet
JP	JP5816631B2	B2	2015-11-18	Espacenet
JP	JP2019509315A	A	2019-04-04	Espacenet
KR	KR20120092163A	A	2012-08-20	Espacenet
KR	KR101742140B1	B1	2017-05-31	Espacenet
KR	KR20170061719A	A	2017-06-05	Espacenet
KR	KR101830728B1	B1	2018-04-04	Espacenet
KR	KR20180128937A	A	2018-12-04	Espacenet
LT	LT2506844T	T	2018-03-12	Espacenet
LT	LT3335707T	T	2024-06-10	Espacenet
LT	LTPA2018011I1	I1	2018-06-25	Espacenet
LT	LTC2506844I2	I2	2022-10-10	Espacenet
LU	LUC00077I2	I2	2018-08-14	Espacenet
MA	MA33853B1	B1	2012-12-03	Espacenet
ME	ME02965B	B	2018-07-20	Espacenet
MX	MX2012006310A	A	2012-06-19	Espacenet
MX	MX351290B	B	2017-10-09	Espacenet
MY	MY184864A	A	2021-04-28	Espacenet
MY	MY207466A	A	2025-02-27	Espacenet
NO	NO2018018I1	I1	2018-06-04	Espacenet
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NZ	NZ600026A	A	2014-06-27	Espacenet
PE	PE20130042A1	A1	2013-02-09	Espacenet
PE	PE20170915A1	A1	2017-07-12	Espacenet
PH	PH12012501083A1	A1	2016-12-23	Espacenet
PL	PL2506844T3	T3	2018-06-29	Espacenet
PL	PL3335707T3	T3	2024-07-29	Espacenet
PT	PT2506844T	T	2018-02-28	Espacenet
PT	PT3335707T	T	2024-05-29	Espacenet
RS	RS56848B1	B1	2018-04-30	Espacenet
RS	RS65494B1	B1	2024-05-31	Espacenet
RU	RU2018131440A	A	2020-04-23	Espacenet
RU	RU2018131440A3	A3	2020-05-18	Espacenet
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SG	SG181087A1	A1	2012-07-30	Espacenet
SI	SI2506844T1	T1	2018-04-30	Espacenet
SI	SI3335707T1	T1	2024-07-31	Espacenet
SM	SMT201800129T1	T1	2018-05-02	Espacenet
SM	SMT202400176T1	T1	2024-07-09	Espacenet
TR	TR201802921T4	T4	2018-03-21	Espacenet
UA	UA106775C2	C2	2014-10-10	Espacenet
US	US2019106451A1	A1	2019-04-11	Espacenet
US	US10738070B2	B2	2020-08-11	Espacenet
US	US2018008582A1	A1	2018-01-11	Espacenet
US	US11090294B2	B2	2021-08-17	Espacenet
US	US20240041846A1	A1	2024-02-08	Espacenet
US	US12396986B2	B2	2025-08-26	Espacenet
US	US2012309725A1	A1	2012-12-06	Espacenet
US	US2016095840A1	A1	2016-04-07	Espacenet
US	US9750726B2	B2	2017-09-05	Espacenet
US	US2020171009A1	A1	2020-06-04	Espacenet
US	US2020407390A1	A1	2020-12-31	Espacenet
US	US2022047565A1	A1	2022-02-17	Espacenet
US	US2022235087A1	A1	2022-07-28	Espacenet
US	US20250009723A1	A1	2025-01-09	Espacenet
US	US20250339413A1	A1	2025-11-06	Espacenet
WO	WO2011067212A1	A1	2011-06-09	Espacenet
WO	WO2017165619A1	A1	2017-09-28	Espacenet
ZA	ZA201203890B	B	2013-11-27	Espacenet

Official File Inspection EPC Art. 128 Public Dossier

Complete European Patent Register Dossier (148 Total Documents)

The full inspection file for Application EP10781527 contains 148 total documents, including all notices of opposition, proprietor counter-statements, examination communications, third-party observations, and procedural forms. Below are all major recorded procedural filings and publication specifications.

Open 148-Doc Register Dossier

Recorded Filings & Patent Specifications

Official publication specifications, opposition filings, proprietor replies, and procedural submissions.

91 Filings Listed

European Patent Specification - Granted Patent (B1)

Publication Specification

Date: 2017-12-20 Procedure: Grant EP2506844B1

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Official European Patent Register Full Dossier

Publication Specification

Date: 2017-12-20 Procedure: All Proceedings (Examination & Opposition) EP10781527

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European Patent Application with Search Report (A1)

Publication Specification

Date: 2011-06-09 Procedure: Publication EP2506844A1

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Opposition rejected

Dossier Filing

Date: 2024-06-07 Procedure: Opposition 0009273

Inspect on Register

New entry: Decision (+date) in appeal procedure

Dossier Filing

Date: 2024-03-26 Procedure: Examination EPIDOSNNOA9O

Inspect on Register

Oral proceedings

Procedural Step

Date: 2024-03-21 Procedure: Examination ORAL

Inspect on Register

Change: Date of oral proceedings

Dossier Filing

Date: 2023-03-17 Procedure: Examination EPIDOSCORA1NO

Inspect on Register

Deletion: Despatch of minutes of oral proceedings

Dossier Filing

Date: 2023-03-17 Procedure: Examination EPIDOSDORA9NO

Inspect on Register

Change - opposition data/opponent's data or that of the opponent's representative

Dossier Filing

Date: 2023-01-20 Procedure: Opposition 0009299OPPO

Inspect on Register

Change: Appeal number

Dossier Filing

Date: 2022-07-06 Procedure: Examination EPIDOSCREFNO

Inspect on Register

Change: Date of receipt of statement of grounds of an appeal

Dossier Filing

Date: 2022-04-13 Procedure: Examination EPIDOSCNOA3O

Inspect on Register

New entry: Date of receipt of statement of grounds of an appeal

Dossier Filing

Date: 2022-04-13 Procedure: Examination EPIDOSNNOA3O

Inspect on Register

Combinations of a muscarinic receptor antagonist and a beta-2 adrenoreceptor agonist

Patent Abstract / Summary

IPC Classifications

Priority Claims

Designated Contracting States (38 EPC States)

Parties & Representation

Applicants

Inventors (6)

Representatives / Agents

Key Procedural Dates

Patent Oppositions

Teva UK Limited

Breuer, Markus

Sima Patent ve Lisanslama Hizmetleri Ltd.Sti.

Teva UK Limited

Breuer, Markus

Teva UK Limited

Legal Status & Event History

Patent & Non-Patent Citations

Cited Patent Documents

Non-Patent Scientific Literature (NPL)

Worldwide Patent Family

Complete European Patent Register Dossier (148 Total Documents)

Recorded Filings & Patent Specifications

European Patent Specification - Granted Patent (B1)

Official European Patent Register Full Dossier

European Patent Application with Search Report (A1)

Opposition rejected

New entry: Decision (+date) in appeal procedure

Oral proceedings

Change: Date of oral proceedings

Deletion: Despatch of minutes of oral proceedings

Change - opposition data/opponent's data or that of the opponent's representative

Change: Appeal number

Change: Date of receipt of statement of grounds of an appeal

New entry: Date of receipt of statement of grounds of an appeal

New entry: Date of receipt of notice of appeal

New entry: Payment of appeal fee following opposition

New entry: Appeal number

Change: Appeal number

New entry: Date of receipt of notice of appeal

New entry: Payment of appeal fee following opposition

New entry: Appeal number

New entry: Despatch of minutes of oral proceedings

Rejection of opposition

New entry: Despatch of communication that opposition is rejected

Oral proceedings

New entry: Date of oral proceedings

Oral proceedings

Deletion: Date of oral proceedings

Deletion: Date of cancellation oral proceedings

New entry: Date of cancellation oral proceedings

New entry: Date of oral proceedings

Change - opposition data/opponent's data or that of the opponent's representative

New entry: Reply of patent proprietor to notice(s) of opposition

Change: Communication of a notice of opposition and request to file observations + time limit

Change - representative

Change - opposition data/opponent's data or that of the opponent's representative

Invitation to proprietor to file observations on the notice of opposition

New entry: Communication of a notice of opposition and request to file observations + time limit

Opposition filed

Change - divisional application(s)

(Expected) grant

New entry: Information about intention to grant a patent

New entry: Receipt of the translation of the claim(s)

New entry: Renewal fee paid

Renewal fee payment

Deletion - Disapproval of the communication of intention to grant the patent by the applicant or resumption of examination proceedings by the EPO

Deletion: Payment of fee for publishing/printing

New entry: Payment of fee for publishing/printing

New entry: Payment of fee for grant

Intention to grant the patent

DISSAPPROVAL_OF_COMMUNICATION_OF_INTENTION_TO_GRANT_PATENT

Intention to grant the patent

New entry: Communication of intention to grant a patent

Change - German title

Change - English title

Change - French title

New entry: Reply to examination report

New entry: Despatch of examination report + time limit