Opposition Filed
Opposition filed by Roche Innovation Center Copenhagen A/S, Roche Innovation Center Copenhagen A/S
EP Register Verified
OLIGOMERIC COMPOUNDS COMPRISING BICYCLIC NUCLEOTIDES AND USES THEREOF
Publication No.
EP2673361
•
App No.
EP12705736
•
Filed by
Ionis Pharmaceuticals, Inc.
•
Filed on
2012-02-08
•
Issued/Published on
2016-04-13
Publication No.
EP2673361
A1
Application No.
EP12705736
Filed: 2012-02-08
Grant Date
2012-02-08
Mention of grant
Active Oppositions
2 Active
EPO Oppositions
Patent Abstract / Summary
Patent abstract is being processed or was not provided in English by the publishing office.
IPC Classifications
C12N15/113, C12N15/11
C12N15/113
Priority Claims
US 201161470927P
Date: 2011-04-01
US 201161440828P
Date: 2011-02-08
US 201161522659P
Date: 2011-08-11
Designated Contracting States (38 EPC States)
Albania
(AL)
Austria
(AT)
Belgium
(BE)
Bulgaria
(BG)
Switzerland
(CH)
Cyprus
(CY)
Czech Republic
(CZ)
Germany
(DE)
Denmark
(DK)
Estonia
(EE)
Spain
(ES)
Finland
(FI)
France
(FR)
United Kingdom
(GB)
Greece
(GR)
Croatia
(HR)
Hungary
(HU)
Ireland
(IE)
Iceland
(IS)
Italy
(IT)
Liechtenstein
(LI)
Lithuania
(LT)
Luxembourg
(LU)
Latvia
(LV)
Monaco
(MC)
North Macedonia
(MK)
Malta
(MT)
Netherlands
(NL)
Norway
(NO)
Poland
(PL)
Portugal
(PT)
Romania
(RO)
Serbia
(RS)
Sweden
(SE)
Slovenia
(SI)
Slovakia
(SK)
San Marino
(SM)
Turkey
(TR)
Parties & Representation
Applicants
Ionis Pharmaceuticals, Inc.
2855 Gazelle Court, Carlsbad, CA 92010
USIsis Pharmaceuticals, Inc.
2855 Gazelle Court, Carlsbad, CA 92010
USInventors (2)
FREIER, Susan, M.
2855 Gazelle Ct., Carlsbad, CA 92010
USSWAYZE, Eric, E.
2855 Gazelle Ct., Carlsbad, CA 92010
USRepresentatives / Agents
Carpmaels & Ransford LLP
One Southampton Row, London WC1B 5HA
GBPotter Clarkson
Chapel Quarter, Mount Street
GBPotter Clarkson LLP
The Belgrave Centre, Talbot Street
GBKey Procedural Dates
Request-For-Examination
2013-09-09
Mention Of Grant Published
2012-02-08
First-Examination-Report-Despatched
2015-03-18
Patent Oppositions
Official opposition proceedings filed against European Patent EP2673361 under EPC Article 99.
#1
Opponent
Company
Roche Innovation Center Copenhagen A/S
Fremtidsvej 3, DK
Representative
Potter Clarkson
Filing
Date
Opposition in Progress
2017-01-03
#2
Opponent
Company
Roche Innovation Center Copenhagen A/S
Fremtidsvej 3, DK
Representative
Potter Clarkson LLP
Filing
Date
Opposition in Progress
2017-01-03
Legal Status & Event History
Official European Patent Office legal and procedural status changes recorded for this file.
No legal events recorded or events are currently synchronizing.
Patent & Non-Patent Citations
Cited documents and prior art referenced in search and examination reports.
Cited Patent Documents
Non-Patent Scientific Literature (NPL)
FREIER ET AL.: "The ups and downs of nucleic acid duplex stability: Structure-stability studies on chemically-modified DNA:RNA duplexes", NUCLEIC ACIDS RESEARCH, vol. 25, no. 22, 1997, pages 4429 - 4443, XP003018113
KURRECK ET AL.: "Design of antisense oligonucleotides stabilized by locked nucleic acids", NUCLEIC ACIDS RESEARCH, vol. 30, no. 9, 2002, pages 1911 - 1918, XP002281375
OBIKA ET AL.: "Inhibition of ICAM-1 gene expression by antisense 2',4'-BNA oligonucleotides.", NUCLEIC ACIDS RESEARCH, vol. 1, no. 1, 2001, pages 145 - 146, XP055265596
FRIEDEN ET AL.: "Expanding the design horizon of antisense oligonucleotides with alphalLNA", NUCLEIC ACIDS RESEARCH, vol. 31, no. 21, 2003, pages 6365 - 6372, XP002281376
TAKAGI-SATO ET AL.: "Fine-Tuning of ENA TM Gapmers as Antisense Oligonucleotides for Sequence-Specific Inhibition", OLIGONUCLEOTIDES, vol. 17, no. 3, 2007, pages 291 - 301, XP055246491
Worldwide Patent Family
Related applications and patents in the same INPADOC worldwide family.
No family members recorded or family data currently updating.
Official File Inspection
EPC Art. 128 Public Dossier
Complete European Patent Register Dossier (148 Total Documents)
The full inspection file for Application EP12705736 contains 148 total documents, including all notices of opposition, proprietor counter-statements, examination communications, third-party observations, and procedural forms. Below are all major recorded procedural filings and publication specifications.
Recorded Filings & Patent Specifications
Official publication specifications, opposition filings, proprietor replies, and procedural submissions.
European Patent Specification - Granted Patent (B1)
Publication Specification
Date: 2016-04-13
Procedure: Grant
EP2673361B1
Official European Patent Register Full Dossier
Publication Specification
Date: 2016-04-13
Procedure: All Proceedings (Examination & Opposition)
EP12705736
European Patent Application with Search Report (A1)
Publication Specification
Date: 2012-08-16
Procedure: Publication
EP2673361A1
Lapse of the patent in a contracting state
Dossier Filing
Date: 2022-06-24
Procedure: Examination
0009250
Lapse of the patent in a contracting state
Dossier Filing
Date: 2022-05-27
Procedure: Examination
0009250
Lapse of the patent in a contracting state
Dossier Filing
Date: 2020-07-10
Procedure: Examination
0009250
Lapse of the patent in a contracting state
Dossier Filing
Date: 2020-04-17
Procedure: Examination
0009250
Lapse of the patent in a contracting state
Dossier Filing
Date: 2019-11-15
Procedure: Examination
0009250
Lapse of the patent in a contracting state
Dossier Filing
Date: 2019-08-16
Procedure: Examination
0009250
Revocation of patent
Dossier Filing
Date: 2019-01-18
Procedure: Examination
0009271
Oral proceedings
Procedural Step
Date: 2018-11-22
Procedure: Examination
ORAL
Lapse of the patent in a contracting state
Dossier Filing
Date: 2018-10-12
Procedure: Examination
0009250
New entry: Date of cancellation oral proceedings
Dossier Filing
Date: 2018-09-29
Procedure: Examination
EPIDOSNORA6O
New entry: Despatch of communication that patent is revoked
Dossier Filing
Date: 2018-09-29
Procedure: Examination
EPIDOSNREV1
Revocation of the patent
Procedural Step
Date: 2018-09-27
Procedure: Examination
REVO
Lapse of the patent in a contracting state
Dossier Filing
Date: 2018-09-21
Procedure: Examination
0009250
Lapse of the patent in a contracting state
Dossier Filing
Date: 2018-02-23
Procedure: Examination
0009250
New entry: Date of oral proceedings
Dossier Filing
Date: 2017-12-28
Procedure: Examination
EPIDOSNORA1O
Lapse of the patent in a contracting state
Dossier Filing
Date: 2017-12-22
Procedure: Examination
0009250
Lapse of the patent in a contracting state
Dossier Filing
Date: 2017-11-17
Procedure: Examination
0009250
Lapse of the patent in a contracting state
Dossier Filing
Date: 2017-10-27
Procedure: Examination
0009250
Lapse of the patent in a contracting state
Dossier Filing
Date: 2017-08-11
Procedure: Examination
0009250
New entry: Reply of patent proprietor to notice(s) of opposition
Dossier Filing
Date: 2017-07-11
Procedure: Opposition
EPIDOSNOBS3
Lapse of the patent in a contracting state
Dossier Filing
Date: 2017-02-24
Procedure: Examination
0009250
Invitation to proprietor to file observations on the notice of opposition
Procedural Step
Date: 2017-02-24
Procedure: Opposition
OBSO
New entry: Communication of a notice of opposition and request to file observations + time limit
Dossier Filing
Date: 2017-02-23
Procedure: Opposition
EPIDOSNOBS2
Lapse of the patent in a contracting state
Dossier Filing
Date: 2017-02-10
Procedure: Examination
0009250
Lapse of the patent in a contracting state
Dossier Filing
Date: 2017-02-03
Procedure: Examination
0009250
Lapse of the patent in a contracting state
Dossier Filing
Date: 2017-01-27
Procedure: Examination
0009250
Lapse of the patent in a contracting state
Dossier Filing
Date: 2017-01-13
Procedure: Examination
0009250
Opposition filed
Dossier Filing
Date: 2017-01-06
Procedure: Opposition
0009260
Lapse of the patent in a contracting state
Dossier Filing
Date: 2016-12-23
Procedure: Examination
0009250
Lapse of the patent in a contracting state
Dossier Filing
Date: 2016-12-16
Procedure: Examination
0009250
Lapse of the patent in a contracting state
Dossier Filing
Date: 2016-11-25
Procedure: Examination
0009250
Lapse of the patent in a contracting state
Dossier Filing
Date: 2016-11-18
Procedure: Examination
0009250
Lapse of the patent in a contracting state
Dossier Filing
Date: 2016-11-11
Procedure: Examination
0009250
Lapse of the patent in a contracting state
Dossier Filing
Date: 2016-11-04
Procedure: Examination
0009250
Lapse of the patent in a contracting state
Dossier Filing
Date: 2016-10-14
Procedure: Examination
0009250
(Expected) grant
Dossier Filing
Date: 2016-03-11
Procedure: Grant
0009210
New entry: Payment of fee for grant
Dossier Filing
Date: 2016-02-25
Procedure: Grant
EPIDOSNIGR3
Change - divisional application(s)
Dossier Filing
Date: 2016-02-12
Procedure: Examination
0008199DANR
New entry: Renewal fee paid
Dossier Filing
Date: 2016-02-12
Procedure: Examination
EPIDOSNRFE2
Renewal fee payment
Procedural Step
Date: 2016-02-10
Procedure: Examination
RFEE
Change - applicant
Dossier Filing
Date: 2016-01-15
Procedure: Examination
0009199APPR
Intention to grant the patent
Procedural Step
Date: 2015-10-13
Procedure: Grant
IGRA
New entry: Communication of intention to grant a patent
Dossier Filing
Date: 2015-10-12
Procedure: Grant
EPIDOSNIGR1
Change - classification
Dossier Filing
Date: 2015-09-25
Procedure: Examination
0008199IPCL
New entry: Reply to examination report
Dossier Filing
Date: 2015-09-18
Procedure: Examination
EPIDOSNEXR3
New entry: Despatch of examination report + time limit
Dossier Filing
Date: 2015-07-24
Procedure: Examination
EPIDOSNEXR2
Communication from the examining division
Procedural Step
Date: 2015-07-14
Procedure: Examination
EXRE
New entry: Reply to examination report
Dossier Filing
Date: 2015-06-22
Procedure: Examination
EPIDOSNEXR3
New entry: Despatch of examination report + time limit
Dossier Filing
Date: 2015-03-30
Procedure: Examination
EPIDOSNEXR2
First examination report
Dossier Filing
Date: 2015-03-20
Procedure: Examination
0009185
Communication from the examining division
Procedural Step
Date: 2015-03-18
Procedure: Examination
EXRE
Preliminary examination - PCT II
Procedural Step
Date: 2015-03-18
Procedure: Examination
PREX
New entry: Renewal fee paid
Dossier Filing
Date: 2015-02-18
Procedure: Examination
EPIDOSNRFE2
Renewal fee payment
Procedural Step
Date: 2015-02-13
Procedure: Examination
RFEE
New entry: Decision on request for further processing
Dossier Filing
Date: 2014-07-31
Procedure: Examination
EPIDOSNRFP4
New entry: Receipt of request for further processing
Dossier Filing
Date: 2014-07-24
Procedure: Examination
EPIDOSNRFP1
New entry: Fee payment for request for further processing
Dossier Filing
Date: 2014-07-24
Procedure: Examination
EPIDOSNRFP2
Amendment by applicant
Dossier Filing
Date: 2014-07-23
Procedure: Examination
EPIDOS ABEX
Amendments
Procedural Step
Date: 2014-07-21
Procedure: Examination
ABEX
Request for further processing
Procedural Step
Date: 2014-07-21
Procedure: Examination
RFPR
Application deemed to be withdrawn
Procedural Step
Date: 2014-05-13
Procedure: Examination
ADWI
New entry: Application deemed to be withdrawn: despatch of communication + time limit
Dossier Filing
Date: 2014-05-12
Procedure: Examination
EPIDOSNADW2
Change - extension states
Dossier Filing
Date: 2014-04-11
Procedure: Examination
0009199EXPT
New entry: Renewal fee paid
Dossier Filing
Date: 2014-02-05
Procedure: Examination
EPIDOSNRFE2
Renewal fee payment
Procedural Step
Date: 2014-01-30
Procedure: Examination
RFEE
Publication in section I.1 EP Bulletin
Dossier Filing
Date: 2013-11-15
Procedure: Examination
0009012
Request for examination filed
Dossier Filing
Date: 2013-11-15
Procedure: Examination
0009171
PCT data prior to European publication
Dossier Filing
Date: 2013-10-02
Procedure: Examination
EPIDOS PCT
PCT data prior to European publication
Dossier Filing
Date: 2013-09-13
Procedure: Examination
EPIDOS PCT
PCT data prior to European publication
Dossier Filing
Date: 2013-09-11
Procedure: Examination
EPIDOS PCT
Payment of national basic fee
Procedural Step
Date: 2013-09-09
Procedure: Examination
FFEE
Payment of the first designation fee
Procedural Step
Date: 2013-09-09
Procedure: Examination
DEST
Payment of the fee for examination
Procedural Step
Date: 2013-09-09
Procedure: Examination
EXAM_PCT
PCT data prior to European publication
Dossier Filing
Date: 2012-08-28
Procedure: Examination
EPIDOS PCT
PCT data prior to European publication
Dossier Filing
Date: 2012-08-17
Procedure: Examination
EPIDOS PCT
PCT data prior to European publication
Dossier Filing
Date: 2012-03-06
Procedure: Examination
EPIDOS PCT
Extension of the patent
Procedural Step
Procedure: Examination
EXPT
Language of the procedure
Procedural Step
Procedure: Examination
PROL
International searching authority
Procedural Step
Procedure: Examination
ISAT