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NEW METHOD FOR SYNTHESIS OF FENFLURAMINE

Publication No. EP3170807

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App No. EP15425100

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Filed by Frau Pharma S.r.l.

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Filed on 2015-11-23

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Issued/Published on 2026-09-23

Official EPO Register

Publication No. EP3170807 A1

Application No. EP15425100 Filed: 2015-11-23

Grant Date 2026-09-23 Mention of grant

Active Oppositions 1 Active EPO Oppositions

Patent Abstract / Summary

[0001] A new process for preparing the fenfluramine molecule or isomers thereof and/or analogs thereof and new compositions containing fenfluramine or isomers thereof and/or analogs thereof obtainable with the claimed process.

IPC Classifications

C07C209/28, C07C209/84, C07C211/29 C07C209/28, C07C209/84, C07C211/29, A61K31/137

Priority Claims

No priority claims recorded

Designated Contracting States (38 EPC States)

AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

Parties & Representation

Applicants

Frau Pharma S.r.l.

Via Trivulzina, 13/1, 20864 Agrate Brianza (MB)

Inventors (2)

Palombi, Giovanni

Viale Foscolo, 88, 20900 Monza

Zagami, Michael

Via G. Bruno, 30, 20023 Cerro Maggiore MI

Representatives / Agents

Modiano, Micaela Nadia, et al

Modiano & Partners, Via Meravigli, 16

Heller, Benjamin Henry

Kilburn & Strode LLP, Lacon London

Key Procedural Dates

Proceedings-Stay 2019-12-06

Proceedings-Resumed 2026-08-03

Request-For-Examination 2017-11-02

First-Examination-Report-Despatched 2018-06-07

Legal Status & Event History

Official European Patent Office legal and procedural status changes recorded for this file.

49 Events Recorded

Date	Code	Event Description	Auth
2017-05-24	AX	REQUEST FOR EXTENSION OF THE EUROPEAN PATENT	EP
2017-05-24	AK	DESIGNATED CONTRACTING STATES	EP
2017-12-13	RBV	DESIGNATED CONTRACTING STATES (CORRECTED)	EP
2017-12-13	17P	REQUEST FOR EXAMINATION FILED	EP
2018-07-11	17Q	FIRST EXAMINATION REPORT DESPATCHED	EP
2019-01-09	RIC1	INFORMATION PROVIDED ON IPC CODE ASSIGNED BEFORE GRANT	EP
2019-01-23	INTG	INTENTION TO GRANT ANNOUNCED	EP
2019-04-03	INTC	INTENTION TO GRANT ANNOUNCED (DELETED)	EP
2019-07-31	INTG	INTENTION TO GRANT ANNOUNCED	EP
2019-12-11	AK	DESIGNATED CONTRACTING STATES	EP
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2020-01-15	29A	PROCEEDINGS STAYED AFTER GRANT	EP
2020-01-15	DB1	PUBLICATION OF PATENT CANCELLED	EP
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2019-11-08	GRAA	(EXPECTED) GRANT	EP
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2017-04-21	STAA	INFORMATION ON THE STATUS OF AN EP PATENT APPLICATION OR GRANTED EP PATENT	EP
2026-02-03	TPAC	OBSERVATIONS FILED BY THIRD PARTIES	EP
2026-06-10	19F	RESUMPTION OF PROCEEDINGS BEFORE GRANT (AFTER STAY OF PROCEEDINGS)	EP
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2026-08-21	GRAA	(EXPECTED) GRANT	EP
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Patent & Non-Patent Citations

Cited documents and prior art referenced in search and examination reports.

66 Citations

Cited Patent Documents

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DE1593595 1970-12-03

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US3769319 1973-10-30

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NL7215548 1974-05-20

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EP0810195 1997-12-03

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EP0882700 1998-12-09

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EP0301925 1989-02-01

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US3198834

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Non-Patent Scientific Literature (NPL)

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[XDI] - DATABASE CASREACT Chemical Abstracts Service, Columbus, OH, US; 2014, XP002757295, Database accession no. 160:218960

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- D10 - STEFFEN GRESSIES: "Final Report: Attempted Synthesis of Fenfluramine", NUVISAN, 2025

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- XU YONGNAN, JI SHUANG, AN YONGXIAN, JIN MEISHU, JIN FENGXUE: "A new method of fenfluramine synthesis", SHENYANG YAOKE DAXUE XUEBAO - JOURNAL OF SHENYANG PHARMACEUTICAL UNIVERSITY., CHINESE ELECTRONIC PERIODICAL SERVICES, LIAONING, CN, vol. 12, no. 3, 1 July 1995 (1995-07-01), LIAONING, CN , pages 171 - 173, XP093424543, ISSN: 1006-2858, DOI: 10.14066/j.cnki.cn21-1349/r.1995.03.004

- NEUDÖRFFER ANNE, MUELLER MELANIE, MARTINEZ CLAIRE-MARIE, MECHAN ANNIS, MCCANN UNA, RICAURTE GEORGE A., LARGERON MARTINE: "Synthesis and Neurotoxicity Profile of 2,4,5-Trihydroxymethamphetamine and Its 6-(N-Acetylcystein-S-yl) Conjugate", CHEMICAL RESEARCH IN TOXICOLOGY, AMERICAN CHEMICAL SOCIETY, WASHINGTON, DC, US, vol. 24, no. 6, 20 June 2011 (2011-06-20), US , pages 968 - 978, XP093423469, ISSN: 0893-228X, DOI: 10.1021/tx2001459

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- D23 - Opinion of the Court-Appointed Expert (Court Of Milan, Civil Section XIV, Case No. 22153/2025)

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Worldwide Patent Family

Related applications and patents in the same INPADOC worldwide family.

3 Family Members

Country	Publication Number	Kind	Publication Date	Action
EP	EP3170807A1	A1	2017-05-24	Espacenet
EP	EP3170807B1	B1	2026-09-23	Espacenet
DK	DK3170807T3	T3	2026-10-05	Espacenet

Official File Inspection EPC Art. 128 Public Dossier

Complete European Patent Register Dossier (148 Total Documents)

The full inspection file for Application EP15425100 contains 148 total documents, including all notices of opposition, proprietor counter-statements, examination communications, third-party observations, and procedural forms. Below are all major recorded procedural filings and publication specifications.

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NEW METHOD FOR SYNTHESIS OF FENFLURAMINE

Patent Abstract / Summary

IPC Classifications

Priority Claims

Designated Contracting States (38 EPC States)

Parties & Representation

Applicants

Inventors (2)

Representatives / Agents

Key Procedural Dates

Patent Oppositions

UCB Pharma S.A.

Legal Status & Event History

Patent & Non-Patent Citations

Cited Patent Documents

Non-Patent Scientific Literature (NPL)

Worldwide Patent Family

Complete European Patent Register Dossier (148 Total Documents)

Recorded Filings & Patent Specifications

European Patent Specification - Granted Patent (B1)

Official European Patent Register Full Dossier

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