DOSAGE REGIMEN FOR A S1P RECEPTOR AGONIST
Patent Abstract / Summary
S1P receptor modulators or agonists are administered following a dosage regimen whereby during the initial days of treatment the daily dosage is lower than the standard daily dosage.
IPC Classifications
Priority Claims
Designated Contracting States (36 EPC States)
Parties & Representation
Applicants
Novartis AG
Lichtstrasse 35, 4056 Basel
CHInventors (4)
SCHMOUDER, Robert
Novartis Pharmaceuticals Corporation, One Health Plaza
USDUMORTIER, Thomas
Novartis Pharma AG, Postfach
CHDAVID, Olivier
Novartis Pharma AG, Postfach
CHLOOBY, Michael
Novartis Pharma AG, Postfach
CHRepresentatives / Agents
Elkington and Fife LLP
Prospect House, 8 Pembroke Road
GBWiessner, Michael
Novartis Pharma AG, Patent Department
CHHamm&Wittkopp Patentanwälte PartmbB
Jungfernstieg 38, 20354 Hamburg
DEDr. Schön, Neymeyr & Partner Patentanwälte mbB
Bavariaring 26, 80336 Munich
DEDr. Schoen, Neymeyr & Partner Patentanwälte mbB
Bavariaring 26, 80336 Munich
DEKey Procedural Dates
Patent Oppositions
Official opposition proceedings filed against European Patent EP3453387 under EPC Article 99.
von Seebach, Malte
Jungfernstieg 38, DE
Hamm&Wittkopp Patentanwälte PartmbB
2021-03-03
Hamm&Wittkopp Patentanwälte PartmbB
Jungfernstieg 38, DE
Hamm&Wittkopp Patentanwälte PartmbB
2021-03-03
Laboratorios Liconsa, S.A.
Gran Via Carlos III, 98, 7th floor, ES
Dr. Schön, Neymeyr & Partner Patentanwälte mbB
2021-03-03
Laboratorios Liconsa, S.A.
Gran Via Carlos III, 98, 7th floor, ES
Dr. Schoen, Neymeyr & Partner Patentanwälte mbB
2021-03-03
Legal Status & Event History
Official European Patent Office legal and procedural status changes recorded for this file.
| Date | Code | Event Description | Auth |
|---|---|---|---|
| 2019-03-13 | 17P | REQUEST FOR EXAMINATION FILED | EP |
| 2019-03-13 | AC | DIVISIONAL APPLICATION: REFERENCE TO EARLIER APPLICATION | EP |
| 2019-03-13 | AK | DESIGNATED CONTRACTING STATES | EP |
| 2019-03-13 | AX | REQUEST FOR EXTENSION OF THE EUROPEAN PATENT | EP |
| 2019-05-15 | 17Q | FIRST EXAMINATION REPORT DESPATCHED | EP |
| 2019-10-09 | RAX | REQUESTED EXTENSION STATES OF THE EUROPEAN PATENT HAVE CHANGED | EP |
| 2019-10-09 | RBV | DESIGNATED CONTRACTING STATES (CORRECTED) | EP |
| 2020-04-15 | RIC1 | INFORMATION PROVIDED ON IPC CODE ASSIGNED BEFORE GRANT | EP |
| 2020-04-29 | INTG | INTENTION TO GRANT ANNOUNCED | EP |
| 2020-04-29 | REG | REFERENCE TO A NATIONAL CODE | EP |
| 2020-06-03 | AX | REQUEST FOR EXTENSION OF THE EUROPEAN PATENT | EP |
| 2020-06-03 | AC | DIVISIONAL APPLICATION: REFERENCE TO EARLIER APPLICATION | EP |
| 2020-06-03 | AK | DESIGNATED CONTRACTING STATES | EP |
| 2020-06-03 | REG | REFERENCE TO A NATIONAL CODE | EP |
| 2020-06-15 | REG | REFERENCE TO A NATIONAL CODE | EP |
| 2020-06-25 | REG | REFERENCE TO A NATIONAL CODE | EP |
| 2020-08-10 | REG | REFERENCE TO A NATIONAL CODE | EP |
| 2020-08-18 | REG | REFERENCE TO A NATIONAL CODE | EP |
| 2020-08-14 | REG | REFERENCE TO A NATIONAL CODE | EP |
| 2020-08-24 | REG | REFERENCE TO A NATIONAL CODE | EP |
| 2020-08-23 | REG | REFERENCE TO A NATIONAL CODE | EP |
| 2020-10-15 | REG | REFERENCE TO A NATIONAL CODE | EP |
| 2020-10-21 | REG | REFERENCE TO A NATIONAL CODE | EP |
| 2020-11-03 | REG | REFERENCE TO A NATIONAL CODE | EP |
| 2020-07-27 | REG | REFERENCE TO A NATIONAL CODE | EP |
| 2020-08-03 | REG | REFERENCE TO A NATIONAL CODE | EP |
| 2020-08-11 | REG | REFERENCE TO A NATIONAL CODE | EP |
| 2020-12-25 | REG | REFERENCE TO A NATIONAL CODE | EP |
| 2020-12-11 | REG | REFERENCE TO A NATIONAL CODE | EP |
| 2020-05-01 | GRAA | (EXPECTED) GRANT | EP |
| 2020-03-30 | GRAP | DESPATCH OF COMMUNICATION OF INTENTION TO GRANT A PATENT | EP |
| 2020-04-22 | GRAS | GRANT FEE PAID | EP |
| 2021-03-09 | REG | REFERENCE TO A NATIONAL CODE | EP |
| 2021-03-03 | REG | REFERENCE TO A NATIONAL CODE | EP |
| 2021-04-07 | 26 | OPPOSITION FILED | EP |
| 2019-02-08 | PUAI | PUBLIC REFERENCE MADE UNDER ARTICLE 153(3) EPC TO A PUBLISHED INTERNATIONAL APPLICATION THAT HAS ENTERED THE EUROPEAN PHASE | EP |
| 2020-05-01 | STAA | INFORMATION ON THE STATUS OF AN EP PATENT APPLICATION OR GRANTED EP PATENT | EP |
| 2020-03-30 | STAA | INFORMATION ON THE STATUS OF AN EP PATENT APPLICATION OR GRANTED EP PATENT | EP |
| 2019-04-10 | STAA | INFORMATION ON THE STATUS OF AN EP PATENT APPLICATION OR GRANTED EP PATENT | EP |
| 2019-02-08 | STAA | INFORMATION ON THE STATUS OF AN EP PATENT APPLICATION OR GRANTED EP PATENT | EP |
| 2021-04-28 | REG | REFERENCE TO A NATIONAL CODE | EP |
| 2021-04-06 | REG | REFERENCE TO A NATIONAL CODE | EP |
| 2021-05-19 | R26 | OPPOSITION FILED (CORRECTED) | EP |
| 2021-07-27 | PLBB | REPLY OF PATENT PROPRIETOR TO NOTICE(S) OF OPPOSITION RECEIVED | EP |
| 2021-04-16 | PLAB | OPPOSITION DATA, OPPONENT'S DATA OR THAT OF THE OPPONENT'S REPRESENTATIVE MODIFIED | EP |
| 2021-03-15 | PLAX | NOTICE OF OPPOSITION AND REQUEST TO FILE OBSERVATION + TIME LIMIT SENT | EP |
| 2021-03-05 | PLBI | OPPOSITION FILED | EP |
| 2022-01-07 | REG | REFERENCE TO A NATIONAL CODE | EP |
| 2022-07-15 | REG | REFERENCE TO A NATIONAL CODE | EP |
| 2023-01-20 | REG | REFERENCE TO A NATIONAL CODE | EP |
| 2023-06-21 | P01 | OPT-OUT OF THE COMPETENCE OF THE UNIFIED PATENT COURT (UPC) REGISTERED | EP |
| 2023-12-22 | REG | REFERENCE TO A NATIONAL CODE | EP |
| 2024-09-06 | PLBP | OPPOSITION WITHDRAWN | EP |
| 2024-10-18 | PLBP | OPPOSITION WITHDRAWN | EP |
| 2024-11-08 | PLBP | OPPOSITION WITHDRAWN | EP |
| 2024-12-15 | RDAF | COMMUNICATION DESPATCHED THAT PATENT IS REVOKED | EP |
| 2025-01-10 | APBP | DATE OF RECEIPT OF NOTICE OF APPEAL RECORDED | EP |
| 2025-01-03 | REG | REFERENCE TO A NATIONAL CODE | EP |
| 2024-10-09 | REG | REFERENCE TO A NATIONAL CODE | EP |
| 2025-04-16 | APBQ | DATE OF RECEIPT OF STATEMENT OF GROUNDS OF APPEAL RECORDED | EP |
| 2025-04-16 | APAW | APPEAL REFERENCE DELETED | EP |
| 2025-04-29 | APAH | APPEAL REFERENCE MODIFIED | EP |
| 2025-12-15 | PGFP | ANNUAL FEE PAID TO NATIONAL OFFICE [ANNOUNCED VIA POSTGRANT INFORMATION FROM NATIONAL OFFICE TO EPO] | EP |
| 2026-01-01 | REG | REFERENCE TO A NATIONAL CODE | EP |
| 2026-01-02 | REG | REFERENCE TO A NATIONAL CODE | EP |
| 2026-01-08 | PGFP | ANNUAL FEE PAID TO NATIONAL OFFICE [ANNOUNCED VIA POSTGRANT INFORMATION FROM NATIONAL OFFICE TO EPO] | EP |
| 2026-01-09 | PGFP | ANNUAL FEE PAID TO NATIONAL OFFICE [ANNOUNCED VIA POSTGRANT INFORMATION FROM NATIONAL OFFICE TO EPO] | EP |
| 2026-01-12 | PGFP | ANNUAL FEE PAID TO NATIONAL OFFICE [ANNOUNCED VIA POSTGRANT INFORMATION FROM NATIONAL OFFICE TO EPO] | EP |
| 2026-01-13 | PGFP | ANNUAL FEE PAID TO NATIONAL OFFICE [ANNOUNCED VIA POSTGRANT INFORMATION FROM NATIONAL OFFICE TO EPO] | EP |
| 2026-01-14 | PGFP | ANNUAL FEE PAID TO NATIONAL OFFICE [ANNOUNCED VIA POSTGRANT INFORMATION FROM NATIONAL OFFICE TO EPO] | EP |
| 2026-01-15 | PGFP | ANNUAL FEE PAID TO NATIONAL OFFICE [ANNOUNCED VIA POSTGRANT INFORMATION FROM NATIONAL OFFICE TO EPO] | EP |
| 2026-01-16 | PGFP | ANNUAL FEE PAID TO NATIONAL OFFICE [ANNOUNCED VIA POSTGRANT INFORMATION FROM NATIONAL OFFICE TO EPO] | EP |
| 2026-01-19 | PGFP | ANNUAL FEE PAID TO NATIONAL OFFICE [ANNOUNCED VIA POSTGRANT INFORMATION FROM NATIONAL OFFICE TO EPO] | EP |
| 2026-01-20 | PGFP | ANNUAL FEE PAID TO NATIONAL OFFICE [ANNOUNCED VIA POSTGRANT INFORMATION FROM NATIONAL OFFICE TO EPO] | EP |
| 2026-01-22 | PGFP | ANNUAL FEE PAID TO NATIONAL OFFICE [ANNOUNCED VIA POSTGRANT INFORMATION FROM NATIONAL OFFICE TO EPO] | EP |
| 2026-01-23 | PGFP | ANNUAL FEE PAID TO NATIONAL OFFICE [ANNOUNCED VIA POSTGRANT INFORMATION FROM NATIONAL OFFICE TO EPO] | EP |
| 2026-01-26 | PGFP | ANNUAL FEE PAID TO NATIONAL OFFICE [ANNOUNCED VIA POSTGRANT INFORMATION FROM NATIONAL OFFICE TO EPO] | EP |
| 2026-01-27 | PGFP | ANNUAL FEE PAID TO NATIONAL OFFICE [ANNOUNCED VIA POSTGRANT INFORMATION FROM NATIONAL OFFICE TO EPO] | EP |
| 2026-01-30 | PGFP | ANNUAL FEE PAID TO NATIONAL OFFICE [ANNOUNCED VIA POSTGRANT INFORMATION FROM NATIONAL OFFICE TO EPO] | EP |
| 2026-03-03 | APBU | APPEAL PROCEDURE CLOSED | EP |
| 2026-03-06 | RDAG | PATENT REVOKED | EP |
| 2026-03-06 | STAA | INFORMATION ON THE STATUS OF AN EP PATENT APPLICATION OR GRANTED EP PATENT | EP |
| 2026-03-11 | REG | REFERENCE TO A NATIONAL CODE | EP |
| 2026-02-27 | REG | REFERENCE TO A NATIONAL CODE | EP |
| 2026-03-25 | REG | REFERENCE TO A NATIONAL CODE | EP |
| 2026-04-08 | 27W | PATENT REVOKED | EP |
| 2026-04-08 | GBPR | GB: PATENT REVOKED UNDER ART. 102 OF THE EP CONVENTION DESIGNATING THE UK AS CONTRACTING STATE | EP |
| 2026-04-10 | PGFP | ANNUAL FEE PAID TO NATIONAL OFFICE [ANNOUNCED VIA POSTGRANT INFORMATION FROM NATIONAL OFFICE TO EPO] | EP |
| 2026-04-15 | REG | REFERENCE TO A NATIONAL CODE | EP |
| 2026-04-08 | REG | REFERENCE TO A NATIONAL CODE | EP |
| 2026-04-23 | PGFP | ANNUAL FEE PAID TO NATIONAL OFFICE [ANNOUNCED VIA POSTGRANT INFORMATION FROM NATIONAL OFFICE TO EPO] | EP |
| 2026-05-08 | REG | REFERENCE TO A NATIONAL CODE | EP |
| 2026-05-15 | REG | REFERENCE TO A NATIONAL CODE | EP |
| 2026-07-10 | PG25 | LAPSED IN A CONTRACTING STATE [ANNOUNCED VIA POSTGRANT INFORMATION FROM NATIONAL OFFICE TO EPO] | EP |
| 2026-08-11 | REG | REFERENCE TO A NATIONAL CODE | EP |
Patent & Non-Patent Citations
Cited documents and prior art referenced in search and examination reports.
Cited Patent Documents
Non-Patent Scientific Literature (NPL)
Worldwide Patent Family
Related applications and patents in the same INPADOC worldwide family.
| Country | Publication Number | Kind | Publication Date | Action |
|---|---|---|---|---|
| EP | EP3453387A1 | A1 | 2019-03-13 | Espacenet |
| EP | EP3453387B1 | B1 | 2020-06-03 | Espacenet |
| AR | AR074826A1 | A1 | 2011-02-16 | Espacenet |
| AU | AU2009330176A1 | A1 | 2011-07-07 | Espacenet |
| AU | AU2009330176B2 | B2 | 2014-03-06 | Espacenet |
| AU | AU2009330176C1 | C1 | 2016-12-08 | Espacenet |
| AU | AU2009330176C9 | C9 | 2017-01-05 | Espacenet |
| BR | BRPI0923500A2 | A2 | 2018-05-29 | Espacenet |
| CA | CA2747802A1 | A1 | 2010-07-01 | Espacenet |
| CA | CA2747802C | C | 2021-02-09 | Espacenet |
| CL | CL2011001529A1 | A1 | 2012-02-24 | Espacenet |
| CL | CL2013001558A1 | A1 | 2013-10-25 | Espacenet |
| CN | CN102264359A | A | 2011-11-30 | Espacenet |
| CO | CO6390117A2 | A2 | 2012-02-29 | Espacenet |
| CR | CR20110274A | A | 2011-07-19 | Espacenet |
| CU | CU20110136A7 | A7 | 2012-01-31 | Espacenet |
| CU | CU20130155A7 | A7 | 2014-02-28 | Espacenet |
| CY | CY1116990T1 | T1 | 2017-04-05 | Espacenet |
| CY | CY1122812T1 | T1 | 2021-05-05 | Espacenet |
| CY | CY1123255T1 | T1 | 2021-10-29 | Espacenet |
| CY | CY2020036I1 | I1 | 2021-03-12 | Espacenet |
| CY | CY2020036I2 | I2 | 2021-06-25 | Espacenet |
| CY | CY2025012I1 | I1 | 2026-02-25 | Espacenet |
| CY | CY2025012I2 | I2 | 2026-02-25 | Espacenet |
| DK | DK2379067T3 | T3 | 2015-12-07 | Espacenet |
| DK | DK3409274T3 | T3 | 2019-12-16 | Espacenet |
| DK | DK3453387T3 | T3 | 2020-08-10 | Espacenet |
| DK | DK4098256T3 | T3 | 2025-04-22 | Espacenet |
| DK | DK4098256T5 | T5 | 2025-07-21 | Espacenet |
| EA | EA201100978A1 | A1 | 2012-01-30 | Espacenet |
| EC | ECSP11011222A | A | 2011-08-31 | Espacenet |
| EP | EP2379067A1 | A1 | 2011-10-26 | Espacenet |
| EP | EP2379067B1 | B1 | 2015-09-02 | Espacenet |
| EP | EP2907511A1 | A1 | 2015-08-19 | Espacenet |
| EP | EP3120844A1 | A1 | 2017-01-25 | Espacenet |
| EP | EP3409274A1 | A1 | 2018-12-05 | Espacenet |
| EP | EP3409274B1 | B1 | 2019-11-20 | Espacenet |
| EP | EP3677260A1 | A1 | 2020-07-08 | Espacenet |
| EP | EP4098256A1 | A1 | 2022-12-07 | Espacenet |
| EP | EP4098256B1 | B1 | 2025-02-26 | Espacenet |
| EP | EP4098256B9 | B9 | 2025-06-18 | Espacenet |
| ES | ES2552823T3 | T3 | 2015-12-02 | Espacenet |
| ES | ES2760607T3 | T3 | 2020-05-14 | Espacenet |
| ES | ES2810823T3 | T3 | 2021-03-09 | Espacenet |
| ES | ES3017254T3 | T3 | 2025-05-12 | Espacenet |
| FI | FI4098256T3 | T3 | 2025-03-31 | Espacenet |
| FI | FIC20253002I1 | I1 | 2025-05-23 | Espacenet |
| FR | FR20C1060I1 | I1 | 2020-12-25 | Espacenet |
| FR | FR25C1012I1 | I1 | 2025-06-13 | Espacenet |
| HN | HN2011001759A | A | 2013-11-26 | Espacenet |
| HR | HRP20151190T1 | T1 | 2016-01-01 | Espacenet |
| HR | HRP20192175T1 | T1 | 2020-03-20 | Espacenet |
| HR | HRP20201167T1 | T1 | 2020-12-11 | Espacenet |
| HR | HRP20250568T1 | T1 | 2025-07-04 | Espacenet |
| HU | HUE026869T2 | T2 | 2016-08-29 | Espacenet |
| HU | HUE048717T2 | T2 | 2020-08-28 | Espacenet |
| HU | HUE048717T4 | T4 | 2022-02-28 | Espacenet |
| HU | HUE052048T2 | T2 | 2021-04-28 | Espacenet |
| HU | HUE071189T2 | T2 | 2025-08-28 | Espacenet |
| HU | HUS2000046I1 | I1 | 2020-12-28 | Espacenet |
| HU | HUS2500026I1 | I1 | 2025-07-28 | Espacenet |
| IL | IL274756A | A | 2020-07-30 | Espacenet |
| IL | IL278914A | A | 2021-01-31 | Espacenet |
| JP | JP2012513401A | A | 2012-06-14 | Espacenet |
| JP | JP2014144970A | A | 2014-08-14 | Espacenet |
| JP | JP2016135752A | A | 2016-07-28 | Espacenet |
| JP | JP2017141238A | A | 2017-08-17 | Espacenet |
| JP | JP2019167360A | A | 2019-10-03 | Espacenet |
| JP | JP7329965B2 | B2 | 2023-08-21 | Espacenet |
| JP | JP2022103194A | A | 2022-07-07 | Espacenet |
| JP | JP2024129030A | A | 2024-09-26 | Espacenet |
| KR | KR20110096175A | A | 2011-08-29 | Espacenet |
| KR | KR101347919B1 | B1 | 2014-01-07 | Espacenet |
| LT | LT3409274T | T | 2020-02-10 | Espacenet |
| LT | LT3453387T | T | 2020-08-25 | Espacenet |
| LT | LT4098256T | T | 2025-06-10 | Espacenet |
| LT | LTPA2020005I1 | I1 | 2020-12-10 | Espacenet |
| LT | LTPA2025520I1 | I1 | 2025-06-25 | Espacenet |
| LU | LUC00183I2 | I2 | 2024-07-01 | Espacenet |
| MA | MA32981B1 | B1 | 2012-01-02 | Espacenet |
| ME | ME03594B | B | 2020-07-20 | Espacenet |
| ME | ME03802B | B | 2021-04-20 | Espacenet |
| MX | MX2011006623A | A | 2011-07-12 | Espacenet |
| MX | MX2021010759A | A | 2022-07-19 | Espacenet |
| MX | MX385959B | B | 2025-03-18 | Espacenet |
| NO | NO2020038I1 | I1 | 2020-11-18 | Espacenet |
| NZ | NZ593065A | A | 2012-11-30 | Espacenet |
| PE | PE20120337A1 | A1 | 2012-04-24 | Espacenet |
| PL | PL2379067T3 | T3 | 2016-02-29 | Espacenet |
| PL | PL3409274T3 | T3 | 2020-06-01 | Espacenet |
| PL | PL3453387T3 | T3 | 2020-11-02 | Espacenet |
| PL | PL4098256T3 | T3 | 2025-06-09 | Espacenet |
| PT | PT2379067E | E | 2015-12-23 | Espacenet |
| PT | PT3409274T | T | 2019-12-17 | Espacenet |
| PT | PT3453387T | T | 2020-08-11 | Espacenet |
| PT | PT4098256T | T | 2025-04-10 | Espacenet |
| RS | RS59857B1 | B1 | 2020-02-28 | Espacenet |
| RS | RS60666B1 | B1 | 2020-09-30 | Espacenet |
| RS | RS66784B1 | B1 | 2025-06-30 | Espacenet |
| RS | RS66784B9 | B9 | 2025-08-29 | Espacenet |
| SG | SG171404A1 | A1 | 2011-07-28 | Espacenet |
| SI | SI2379067T1 | T1 | 2016-01-29 | Espacenet |
| SI | SI3409274T1 | T1 | 2020-03-31 | Espacenet |
| SI | SI3453387T1 | T1 | 2020-10-30 | Espacenet |
| SI | SI4098256T1 | T1 | 2025-06-30 | Espacenet |
| SM | SMT202000054T1 | T1 | 2020-03-13 | Espacenet |
| SM | SMT202000441T1 | T1 | 2020-09-10 | Espacenet |
| TN | TN2011000272A1 | A1 | 2012-12-17 | Espacenet |
| TW | TW201028143A | A | 2010-08-01 | Espacenet |
| US | US2010160259A1 | A1 | 2010-06-24 | Espacenet |
| US | US2011257133A1 | A1 | 2011-10-20 | Espacenet |
| US | US2014066657A1 | A1 | 2014-03-06 | Espacenet |
| US | US2014148415A1 | A1 | 2014-05-29 | Espacenet |
| US | US2016081949A1 | A1 | 2016-03-24 | Espacenet |
| US | US2016263061A1 | A1 | 2016-09-15 | Espacenet |
| US | US2017189353A1 | A1 | 2017-07-06 | Espacenet |
| US | US2018289638A1 | A1 | 2018-10-11 | Espacenet |
| US | US2019091180A1 | A1 | 2019-03-28 | Espacenet |
| US | US2020330407A1 | A1 | 2020-10-22 | Espacenet |
| US | US2022142949A1 | A1 | 2022-05-12 | Espacenet |
| US | US20250262171A1 | A1 | 2025-08-21 | Espacenet |
| UY | UY32352A | A | 2010-07-30 | Espacenet |
| WO | WO2010075239A1 | A1 | 2010-07-01 | Espacenet |
| ZA | ZA201103863B | B | 2012-10-31 | Espacenet |
| ZA | ZA201205942B | B | 2013-03-27 | Espacenet |
Complete European Patent Register Dossier (148 Total Documents)
The full inspection file for Application EP18201062 contains 148 total documents, including all notices of opposition, proprietor counter-statements, examination communications, third-party observations, and procedural forms. Below are all major recorded procedural filings and publication specifications.
Recorded Filings & Patent Specifications
Official publication specifications, opposition filings, proprietor replies, and procedural submissions.