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BINDING MOLECULES FOR BCMA AND CD3

Publication No. EP3611193

•

App No. EP19196304

•

Filed by Amgen Research (Munich) GmbH

•

Filed on 2012-11-15

•

Issued/Published on 2026-08-26

Official EPO Register

Publication No. EP3611193 A1

Application No. EP19196304 Filed: 2012-11-15

Grant Date 2026-08-26 Mention of grant

Active Oppositions 3 Active EPO Oppositions

Patent Abstract / Summary

[0001] The present invention relates to a binding molecule which is at least bispecific comprising a first and a second binding domain, wherein the first binding domain is capable of binding to epitope cluster 3 of BCMA, and the second binding domain is capable of binding to the T cell CD3 receptor complex. Moreover, the invention provides a nucleic acid sequence encoding the binding molecule, a vector comprising said nucleic acid sequence and a host cell transformed or transfected with said vector. Furthermore, the invention provides a process for the production of the binding molecule of the invention, a medical use of said binding molecule and a kit comprising said binding molecule.

IPC Classifications

C07K16/28, A61K39/395, A61P35/02, A61P37/00

Priority Claims

US 201161560144P Date: 2011-11-15

US 201161560149P Date: 2011-11-15

US 201161560162P Date: 2011-11-15

US 201161560178P Date: 2011-11-15

US 201161560183P Date: 2011-11-15

US 201261651486P Date: 2012-05-24

US 201261651474P Date: 2012-05-24

Designated Contracting States (38 EPC States)

AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

Parties & Representation

Applicants

Amgen Research (Munich) GmbH

Staffelseestrasse 2, 81477 München

DE

Amgen Inc.

One Amgen Center Drive, Thousand Oaks, California 91320-1799

US

Amgen, Inc

One Amgen Center Drive, Thousand Oaks, CA 91320-1799

US

Inventors (10)

KUFER, Peter

c/o Amgen Research (Munich) GmbH, Staffelseestrasse 2

DE

RAUM, Tobias

c/o Amgen Research (Munich) GmbH, Staffelseestrasse 2

DE

HOFFMANN, Patrick

c/o Amgen Research (Munich) GmbH, Staffelseestrasse 2

DE

KISCHEL, Roman

c/o Amgen Research (Munich) GmbH, Staffelseestrasse 2

DE

LUTTERBUESE, Ralf

c/o Amgen Research (Munich) GmbH, Staffelseestrasse 2

DE

RAU, Doris

c/o Amgen Research (Munich) GmbH, Staffelseestrasse 2

DE

ADAM, Paul

c/o Boehringer Ingelheim GmbH, Corporate Patents

DE

BORGES, Eric

c/o Boehringer Ingelheim GmbH, Corporate Patents

DE

HEBEIS, Barbara

c/o Boehringer Ingelheim GmbH, Corporate Patents

DE

HIPP, Susanne

c/o Boehringer Ingelheim GmbH, Corporate Patents

DE

Representatives / Agents

Schiweck Weinzierl Koch Patentanwälte Partnerschaft mbB

Ganghoferstraße 68 B, 80339 München

DE

Carpmaels & Ransford LLP

One Southampton Row, London WC1B 5HA

GB

Hoffmann Eitle

Patent- und Rechtsanwälte PartmbB, Arabellastraße 30

DE

Key Procedural Dates

Request-For-Examination 2020-08-18

First-Examination-Report-Despatched 2021-11-16

Patent Oppositions

Official opposition proceedings filed against European Patent EP3611193 under EPC Article 99.

3 ACTIVE OPPONENTS

#1

Opponent Company

Regeneron Pharmaceuticals, Inc.

777 Old Saw Mill River Road, US

Representative

Carpmaels & Ransford LLP

Filing Date

2026-08-26

Opposition in Progress

#2

Opponent Company

AbbVie Inc.

1 North Waukegan Road, US

Representative

Hoffmann Eitle

Filing Date

2026-09-18

Opposition in Progress

#3

Opponent Company

STRAWMAN LIMITED

Office 9, Dalton House, GB

Representative

Hoffmann Eitle

Filing Date

2026-10-06

Opposition in Progress

Legal Status & Event History

Official European Patent Office legal and procedural status changes recorded for this file.

35 Events Recorded

Date	Code	Event Description	Auth
2020-02-19	AK	DESIGNATED CONTRACTING STATES	EP
2020-02-19	AC	DIVISIONAL APPLICATION: REFERENCE TO EARLIER APPLICATION	EP
2020-02-19	AX	REQUEST FOR EXTENSION OF THE EUROPEAN PATENT	EP
2020-04-22	RAP1	PARTY DATA CHANGED (APPLICANT DATA CHANGED OR RIGHTS OF AN APPLICATION TRANSFERRED)	EP
2020-09-23	RBV	DESIGNATED CONTRACTING STATES (CORRECTED)	EP
2020-09-23	RAX	REQUESTED EXTENSION STATES OF THE EUROPEAN PATENT HAVE CHANGED	EP
2020-09-23	17P	REQUEST FOR EXAMINATION FILED	EP
2020-11-06	REG	REFERENCE TO A NATIONAL CODE	EP
2020-12-04	TPAC	OBSERVATIONS FILED BY THIRD PARTIES	EP
2020-01-17	PUAI	PUBLIC REFERENCE MADE UNDER ARTICLE 153(3) EPC TO A PUBLISHED INTERNATIONAL APPLICATION THAT HAS ENTERED THE EUROPEAN PHASE	EP
2020-08-21	STAA	INFORMATION ON THE STATUS OF AN EP PATENT APPLICATION OR GRANTED EP PATENT	EP
2020-01-17	STAA	INFORMATION ON THE STATUS OF AN EP PATENT APPLICATION OR GRANTED EP PATENT	EP
2021-11-12	STAA	INFORMATION ON THE STATUS OF AN EP PATENT APPLICATION OR GRANTED EP PATENT	EP
2021-12-15	17Q	FIRST EXAMINATION REPORT DESPATCHED	EP
2024-02-26	TPAC	OBSERVATIONS FILED BY THIRD PARTIES	EP
2024-08-08	TPAC	OBSERVATIONS FILED BY THIRD PARTIES	EP
2026-07-14	GRAP	DESPATCH OF COMMUNICATION OF INTENTION TO GRANT A PATENT	EP
2026-07-14	STAA	INFORMATION ON THE STATUS OF AN EP PATENT APPLICATION OR GRANTED EP PATENT	EP
2026-07-21	GRAS	GRANT FEE PAID	EP
2026-07-24	GRAA	(EXPECTED) GRANT	EP
2026-07-24	STAA	INFORMATION ON THE STATUS OF AN EP PATENT APPLICATION OR GRANTED EP PATENT	EP
2026-08-12	INTG	INTENTION TO GRANT ANNOUNCED	EP
2026-08-26	AC	DIVISIONAL APPLICATION: REFERENCE TO EARLIER APPLICATION	EP
2026-08-26	AK	DESIGNATED CONTRACTING STATES	EP
2026-08-26	REG	REFERENCE TO A NATIONAL CODE	EP
2026-08-28	PLBI	OPPOSITION FILED	EP
2026-09-02	REG	REFERENCE TO A NATIONAL CODE	EP
2026-09-10	REG	REFERENCE TO A NATIONAL CODE	EP
2026-09-25	PLBI	OPPOSITION FILED	EP
2026-09-30	26	OPPOSITION FILED	EP
2026-09-23	REG	REFERENCE TO A NATIONAL CODE	EP
2026-09-30	REG	REFERENCE TO A NATIONAL CODE	EP
2026-10-09	PLBI	OPPOSITION FILED	EP
2026-10-14	REG	REFERENCE TO A NATIONAL CODE	EP
2026-10-19	REG	REFERENCE TO A NATIONAL CODE	EP

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PH	PH12014501076A1	A1	2014-06-23	Espacenet
PH	PH12014501091A1	A1	2014-07-28	Espacenet
PL	PL2780375T3	T3	2020-01-31	Espacenet
PT	PT2780375T	T	2019-11-12	Espacenet
RS	RS59373B1	B1	2019-11-29	Espacenet
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SI	SI2780375T1	T1	2019-11-29	Espacenet
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TW	TW201326214A	A	2013-07-01	Espacenet
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UA	UA116766C2	C2	2018-05-10	Espacenet
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Official File Inspection EPC Art. 128 Public Dossier

Complete European Patent Register Dossier (148 Total Documents)

The full inspection file for Application EP19196304 contains 148 total documents, including all notices of opposition, proprietor counter-statements, examination communications, third-party observations, and procedural forms. Below are all major recorded procedural filings and publication specifications.

Open 148-Doc Register Dossier

Recorded Filings & Patent Specifications

Official publication specifications, opposition filings, proprietor replies, and procedural submissions.

86 Filings Listed

European Patent Specification - Granted Patent (B1)

Publication Specification

Date: 2026-08-26 Procedure: Grant EP3611193B1

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Official European Patent Register Full Dossier

Publication Specification

Date: 2026-08-26 Procedure: All Proceedings (Examination & Opposition) EP19196304

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European Patent Application with Search Report (A1)

Publication Specification

Date: 2020-02-19 Procedure: Publication EP3611193A1

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Opposition filed

Dossier Filing

Date: 2026-10-09 Procedure: Opposition 0009260

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Opposition filed

Dossier Filing

Date: 2026-09-25 Procedure: Opposition 0009260

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Change - divisional application(s)

Dossier Filing

Date: 2026-08-28 Procedure: Examination 0008299DANR

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Opposition filed

Dossier Filing

Date: 2026-08-28 Procedure: Opposition 0009260

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(Expected) grant

Dossier Filing

Date: 2026-07-24 Procedure: Grant 0009210

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New entry: Payment of fee for grant

Dossier Filing

Date: 2026-07-21 Procedure: Grant EPIDOSNIGR3

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New entry: Payment of fee for publishing/printing

Dossier Filing

Date: 2026-07-21 Procedure: Examination EPIDOSNIGR5

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New entry: Receipt of the translation of the claim(s)

Dossier Filing

Date: 2026-07-21 Procedure: Examination EPIDOSNIGR7

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New entry: Communication of intention to grant a patent

Dossier Filing

Date: 2026-07-14 Procedure: Grant EPIDOSNIGR1

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