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The patent has been granted The patent has been granted, Grant of patent is intended, Examination is in progress, Request for examination was made, The application has been published EP Register Verified

USE OF SUBSTITUTED AMINOPROPIONATE COMPOUNDS IN TREATMENT OF SARS-COV-2 INFECTION

Publication No. EP3854403

•

App No. EP20202229

•

Filed by Academy of Military Medical Sciences

•

Filed on 2020-10-16

•

Issued/Published on 2025-06-18

Official EPO Register

Publication No. EP3854403 A1

Application No. EP20202229 Filed: 2020-10-16

Grant Date 2025-06-18 Mention of grant

Active Oppositions 1 Active EPO Oppositions

Patent Abstract / Summary

[0001] The present application relates to use of a substituted aminopropionate compound represented by Formula I, a geometric isomer, a pharmaceutically acceptable salt, a solvate and/or a hydrate thereof, and a pharmaceutical composition comprising the compound for the treatment of a disease or an infection caused by a SARS-CoV-2. <img class="EMIRef" id="362d9dce-1c2b-40a9-b742-07ffa82b0a24-ia01" />

IPC Classifications

A61K31/685, A61P31/14, A61P11/00

Priority Claims

CN 20201071087 Date: 2020-01-21

Designated Contracting States (38 EPC States)

AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

Parties & Representation

Applicants

Academy of Military Medical Sciences

No. 27 Taiping Road, Haidian District

CN

Inventors (11)

ZHONG, Wu

NO.27,TAIPING ROAD HAIDIAN DISTRICT, BEIJING, 100850

CN

CAO, Ruiyuan

NO.27,TAIPING ROAD HAIDIAN DISTRICT, BEIJING, 100850

CN

XIAO, Gengfu

NO.27,TAIPING ROAD HAIDIAN DISTRICT, BEIJING, 100850

CN

HU, Zhihong

NO.27,TAIPING ROAD HAIDIAN DISTRICT, BEIJING, 100850

CN

WANG, Manli

NO.27,TAIPING ROAD HAIDIAN DISTRICT, BEIJING, 100850

CN

ZHANG, Leike

NO.27,TAIPING ROAD HAIDIAN DISTRICT, BEIJING, 100850

CN

LI, Wei

NO.27,TAIPING ROAD HAIDIAN DISTRICT, BEIJING, 100850

CN

LI, Yuexiang

NO.27,TAIPING ROAD HAIDIAN DISTRICT, BEIJING, 100850

CN

ZHAO, Lei

NO.27,TAIPING ROAD HAIDIAN DISTRICT, BEIJING, 100850

CN

FAN, Shiyong

NO.27,TAIPING ROAD HAIDIAN DISTRICT, BEIJING, 100850

CN

LI, Song

NO.27,TAIPING ROAD HAIDIAN DISTRICT, BEIJING, 100850

CN

Representatives / Agents

Lavoix

Bayerstraße 83, 80335 München

DE

Carpmaels & Ransford LLP

One Southampton Row, London WC1B 5HA

GB

Key Procedural Dates

Request-For-Examination 2022-01-27

Mention Of Grant Published 2025-06-18

First-Examination-Report-Despatched 2023-07-31

Patent Oppositions

Official opposition proceedings filed against European Patent EP3854403 under EPC Article 99.

1 ACTIVE OPPONENT

#1

Opponent Company

Gilead Sciences, Inc.

333 Lakeside Drive, US

Representative

Carpmaels & Ransford LLP

Filing Date

2025-06-18

Opposition in Progress

Legal Status & Event History

Official European Patent Office legal and procedural status changes recorded for this file.

48 Events Recorded

Date	Code	Event Description	Auth
2021-07-28	AK	DESIGNATED CONTRACTING STATES	EP
2021-06-25	PUAI	PUBLIC REFERENCE MADE UNDER ARTICLE 153(3) EPC TO A PUBLISHED INTERNATIONAL APPLICATION THAT HAS ENTERED THE EUROPEAN PHASE	EP
2021-06-25	STAA	INFORMATION ON THE STATUS OF AN EP PATENT APPLICATION OR GRANTED EP PATENT	EP
2022-02-04	STAA	INFORMATION ON THE STATUS OF AN EP PATENT APPLICATION OR GRANTED EP PATENT	EP
2022-03-09	17P	REQUEST FOR EXAMINATION FILED	EP
2022-03-09	RBV	DESIGNATED CONTRACTING STATES (CORRECTED)	EP
2023-07-28	STAA	INFORMATION ON THE STATUS OF AN EP PATENT APPLICATION OR GRANTED EP PATENT	EP
2023-08-30	17Q	FIRST EXAMINATION REPORT DESPATCHED	EP
2025-03-24	GRAP	DESPATCH OF COMMUNICATION OF INTENTION TO GRANT A PATENT	EP
2025-03-24	STAA	INFORMATION ON THE STATUS OF AN EP PATENT APPLICATION OR GRANTED EP PATENT	EP
2025-04-23	INTG	INTENTION TO GRANT ANNOUNCED	EP
2025-05-16	GRAA	(EXPECTED) GRANT	EP
2025-05-09	GRAS	GRANT FEE PAID	EP
2025-05-16	STAA	INFORMATION ON THE STATUS OF AN EP PATENT APPLICATION OR GRANTED EP PATENT	EP
2025-06-18	AK	DESIGNATED CONTRACTING STATES	EP
2025-06-20	PLBI	OPPOSITION FILED	EP
2025-06-18	REG	REFERENCE TO A NATIONAL CODE	EP
2025-07-10	REG	REFERENCE TO A NATIONAL CODE	EP
2025-06-30	REG	REFERENCE TO A NATIONAL CODE	EP
2025-07-15	REG	REFERENCE TO A NATIONAL CODE	EP
2025-07-23	26	OPPOSITION FILED	EP
2025-07-16	REG	REFERENCE TO A NATIONAL CODE	EP
2025-08-20	U01	REQUEST FOR UNITARY EFFECT FILED	EP
2025-08-27	U07	UNITARY EFFECT REGISTERED	EP
2025-09-10	REG	REFERENCE TO A NATIONAL CODE	EP
2025-10-13	PG25	LAPSED IN A CONTRACTING STATE [ANNOUNCED VIA POSTGRANT INFORMATION FROM NATIONAL OFFICE TO EPO]	EP
2025-10-15	U30	ACTION LODGED BEFORE THE UPC [INFORMATION PROVIDED BY THE UPC]	EP
2025-10-17	PG25	LAPSED IN A CONTRACTING STATE [ANNOUNCED VIA POSTGRANT INFORMATION FROM NATIONAL OFFICE TO EPO]	EP
2025-10-22	PG25	LAPSED IN A CONTRACTING STATE [ANNOUNCED VIA POSTGRANT INFORMATION FROM NATIONAL OFFICE TO EPO]	EP
2025-11-01	REG	REFERENCE TO A NATIONAL CODE	EP
2025-11-12	U20	RENEWAL FEE FOR THE EUROPEAN PATENT WITH UNITARY EFFECT PAID	EP
2026-01-08	PG25	LAPSED IN A CONTRACTING STATE [ANNOUNCED VIA POSTGRANT INFORMATION FROM NATIONAL OFFICE TO EPO]	EP
2026-01-13	PG25	LAPSED IN A CONTRACTING STATE [ANNOUNCED VIA POSTGRANT INFORMATION FROM NATIONAL OFFICE TO EPO]	EP
2026-01-16	PGFP	ANNUAL FEE PAID TO NATIONAL OFFICE [ANNOUNCED VIA POSTGRANT INFORMATION FROM NATIONAL OFFICE TO EPO]	EP
2026-01-19	PGFP	ANNUAL FEE PAID TO NATIONAL OFFICE [ANNOUNCED VIA POSTGRANT INFORMATION FROM NATIONAL OFFICE TO EPO]	EP
2026-01-20	PG25	LAPSED IN A CONTRACTING STATE [ANNOUNCED VIA POSTGRANT INFORMATION FROM NATIONAL OFFICE TO EPO]	EP
2026-01-23	PG25	LAPSED IN A CONTRACTING STATE [ANNOUNCED VIA POSTGRANT INFORMATION FROM NATIONAL OFFICE TO EPO]	EP
2026-01-27	PG25	LAPSED IN A CONTRACTING STATE [ANNOUNCED VIA POSTGRANT INFORMATION FROM NATIONAL OFFICE TO EPO]	EP
2026-01-30	PGFP	ANNUAL FEE PAID TO NATIONAL OFFICE [ANNOUNCED VIA POSTGRANT INFORMATION FROM NATIONAL OFFICE TO EPO]	EP
2026-03-20	PLAB	OPPOSITION DATA, OPPONENT'S DATA OR THAT OF THE OPPONENT'S REPRESENTATIVE MODIFIED	EP
2026-03-25	REG	REFERENCE TO A NATIONAL CODE	EP
2026-03-29	PLAX	NOTICE OF OPPOSITION AND REQUEST TO FILE OBSERVATION + TIME LIMIT SENT	EP
2026-04-22	R26	OPPOSITION FILED (CORRECTED)	EP
2026-06-30	PG25	LAPSED IN A CONTRACTING STATE [ANNOUNCED VIA POSTGRANT INFORMATION FROM NATIONAL OFFICE TO EPO]	EP
2026-07-03	PLBB	REPLY OF PATENT PROPRIETOR TO NOTICE(S) OF OPPOSITION RECEIVED	EP
2026-10-09	PGFP	ANNUAL FEE PAID TO NATIONAL OFFICE [ANNOUNCED VIA POSTGRANT INFORMATION FROM NATIONAL OFFICE TO EPO]	EP
2026-10-13	PGFP	ANNUAL FEE PAID TO NATIONAL OFFICE [ANNOUNCED VIA POSTGRANT INFORMATION FROM NATIONAL OFFICE TO EPO]	EP
2026-10-20	PGFP	ANNUAL FEE PAID TO NATIONAL OFFICE [ANNOUNCED VIA POSTGRANT INFORMATION FROM NATIONAL OFFICE TO EPO]	EP

Patent & Non-Patent Citations

Cited documents and prior art referenced in search and examination reports.

7 Citations

Cited Patent Documents

CN202010071087 2020-01-21

Espacenet

WO2017049060 2017-03-23

Espacenet

Non-Patent Scientific Literature (NPL)

- ANONYMOUS: "Gillings research on broad-spectrum antiviral could aid public health response to coronavirus outbreaks - UNC Gillings School of Global Public Health", 10 January 2020 (2020-01-10), XP055782994, Retrieved from the Internet <URL:https://sph.unc.edu/sph-news/gillings-research-on-broad-spectrum-antiviral-could-aid-public-health-response-to-coronavirus-outbreaks/> [retrieved on 20210308]

- NATURE PORTFOLIO MICROBIOLOGY COMMUNITY: "Preparing for future pandemics, today with broad-spectrum antivirals | Nature Portfolio Microbiology Community", 10 January 2020 (2020-01-10), XP055783036, Retrieved from the Internet <URL:https://naturemicrobiologycommunity.nature.com/posts/58125-preparing-for-future-pandemics-today-with-broad-spectrum-antivirals> [retrieved on 20210308]

- SHEAHAN TIMOTHY P. ET AL: "Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses", SCIENCE TRANSLATIONAL MEDICINE, vol. 9, no. 396, 28 June 2017 (2017-06-28), US, pages eaal3653, XP055783008, ISSN: 1946-6234, DOI: 10.1126/scitranslmed.aal3653

- MARIA L. AGOSTINI ET AL: "Coronavirus Susceptibility to the Antiviral Remdesivir (GS5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease", MBIO, vol. 9, no. 2, 6 March 2018 (2018-03-06), pages 1 - 15, XP055677700, DOI: 10.1128/mBio.00221-18

- ALLISON L. TOTURA ET AL: "Broad-spectrum coronavirus antiviral drug discovery", EXPERT OPINION ON DRUG DISCOVERY, vol. 14, no. 4, 8 March 2019 (2019-03-08), London, GB, pages 397 - 412, XP055677701, ISSN: 1746-0441, DOI: 10.1080/17460441.2019.1581171

Worldwide Patent Family

Related applications and patents in the same INPADOC worldwide family.

18 Family Members

Country	Publication Number	Kind	Publication Date	Action
EP	EP3854403A1	A1	2021-07-28	Espacenet
EP	EP3854403B1	B1	2025-06-18	Espacenet
EP	EP3854403C0	C0	2025-06-18	Espacenet
CN	CN111265532A	A	2020-06-12	Espacenet
CN	CN111494396A	A	2020-08-07	Espacenet
CN	CN111494396B	B	2021-06-15	Espacenet
EA	EA202092169A1	A1	2021-07-30	Espacenet
ES	ES3035833T3	T3	2025-09-10	Espacenet
JP	JP2021116295A	A	2021-08-10	Espacenet
JP	JP7847940B2	B2	2026-04-20	Espacenet
JP	JP2024020274A	A	2024-02-14	Espacenet
TW	TW202128186A	A	2021-08-01	Espacenet
TW	TWI805952B	B	2023-06-21	Espacenet
US	US2021220377A1	A1	2021-07-22	Espacenet
US	US2021346411A1	A1	2021-11-11	Espacenet
UY	UY39029A	A	2021-03-26	Espacenet
WO	WO2021147236A1	A1	2021-07-29	Espacenet
WO	WO2021147236A9	A9	2021-09-16	Espacenet

Official File Inspection EPC Art. 128 Public Dossier

Complete European Patent Register Dossier (148 Total Documents)

The full inspection file for Application EP20202229 contains 148 total documents, including all notices of opposition, proprietor counter-statements, examination communications, third-party observations, and procedural forms. Below are all major recorded procedural filings and publication specifications.

Open 148-Doc Register Dossier

Recorded Filings & Patent Specifications

Official publication specifications, opposition filings, proprietor replies, and procedural submissions.

46 Filings Listed

European Patent Specification - Granted Patent (B1)

Publication Specification

Date: 2025-06-18 Procedure: Grant EP3854403B1

View / Download PDF

Official European Patent Register Full Dossier

Publication Specification

Date: 2025-06-18 Procedure: All Proceedings (Examination & Opposition) EP20202229

View / Download PDF

European Patent Application with Search Report (A1)

Publication Specification

Date: 2021-07-28 Procedure: Publication EP3854403A1

View / Download PDF

Oral proceedings

Procedural Step

Date: 2027-03-11 Procedure: Examination ORAL

Inspect on Register

New entry: Date of oral proceedings

Dossier Filing

Date: 2026-08-13 Procedure: Examination EPIDOSNORA1O

Inspect on Register

Change - lapse in a contracting state

Dossier Filing

Date: 2026-07-31 Procedure: Examination 0009299LAPS

Inspect on Register

Lapse of the patent in a contracting state

Dossier Filing

Date: 2026-07-24 Procedure: Examination 0009250

Inspect on Register

New entry: Reply of patent proprietor to notice(s) of opposition

Dossier Filing

Date: 2026-07-03 Procedure: Opposition EPIDOSNOBS3

Inspect on Register

Lapse of the patent in a contracting state

Dossier Filing

Date: 2026-07-03 Procedure: Examination 0009250

Inspect on Register

Invitation to proprietor to file observations on the notice of opposition

Procedural Step

Date: 2026-03-30 Procedure: Opposition OBSO

Inspect on Register

New entry: Communication of a notice of opposition and request to file observations + time limit

Dossier Filing

Date: 2026-03-29 Procedure: Opposition EPIDOSNOBS2

Inspect on Register

Change - opposition data/opponent's data or that of the opponent's representative

Dossier Filing

Date: 2026-03-20 Procedure: Opposition 0009299OPPO

Inspect on Register