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OPHTHALMIC COMPOSITION BASED ON HYALURONIC ACID TO PROTECT FROM DAMAGES CAUSED BY ENVIRONMENTAL POLLUTION

Publication No. EP4157291

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App No. EP21726407

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Filed by Colombo, Stefano

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Filed on 2021-05-19

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Issued/Published on 2025-08-13

Official EPO Register

Publication No. EP4157291 A1

Application No. EP21726407 Filed: 2021-05-19

Grant Date 2025-08-13 Mention of grant

Active Oppositions 1 Active EPO Oppositions

Patent Abstract / Summary

Patent abstract is being processed or was not provided in English by the publishing office.

IPC Classifications

A61K31/728, A61K9/00, A61K47/00, A61P27/02

Priority Claims

IT 20200012535 Date: 2020-05-27

Designated Contracting States (38 EPC States)

AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

Parties & Representation

Applicants

Colombo, Stefano

Via Romulado Marenco 5, 20144 Milano

Inventors (2)

PORCHETTI, Anna

20021 Bollate MI

COLOMBO, Stefano

20144 Milano

Representatives / Agents

De Santis, Giovanni, et al

c/o Giambrocono & C. S.p.A., Via Rosolino Pilo, 19/B

Longoni, Alessandra

AL & Partners Srl Via C. Colombo ang. Via Appiani (Corte del Cotone), 20831 Seregno (MB)

Maiwald GmbH

Elisenhof, Elisenstraße 3

Key Procedural Dates

Request-For-Examination 2022-11-24

Mention Of Grant Published 2025-08-13

First-Examination-Report-Despatched 2024-02-21

Legal Status & Event History

Official European Patent Office legal and procedural status changes recorded for this file.

40 Events Recorded

Date	Code	Event Description	Auth
2021-05-28	STAA	INFORMATION ON THE STATUS OF AN EP PATENT APPLICATION OR GRANTED EP PATENT	EP
2021-12-03	STAA	INFORMATION ON THE STATUS OF AN EP PATENT APPLICATION OR GRANTED EP PATENT	EP
2023-03-03	PUAI	PUBLIC REFERENCE MADE UNDER ARTICLE 153(3) EPC TO A PUBLISHED INTERNATIONAL APPLICATION THAT HAS ENTERED THE EUROPEAN PHASE	EP
2023-03-03	STAA	INFORMATION ON THE STATUS OF AN EP PATENT APPLICATION OR GRANTED EP PATENT	EP
2023-04-05	17P	REQUEST FOR EXAMINATION FILED	EP
2023-04-05	AK	DESIGNATED CONTRACTING STATES	EP
2023-08-30	DAX	REQUEST FOR EXTENSION OF THE EUROPEAN PATENT (DELETED)	EP
2023-08-30	DAV	REQUEST FOR VALIDATION OF THE EUROPEAN PATENT (DELETED)	EP
2024-02-22	STAA	INFORMATION ON THE STATUS OF AN EP PATENT APPLICATION OR GRANTED EP PATENT	EP
2024-03-27	17Q	FIRST EXAMINATION REPORT DESPATCHED	EP
2025-04-16	GRAP	DESPATCH OF COMMUNICATION OF INTENTION TO GRANT A PATENT	EP
2025-04-16	STAA	INFORMATION ON THE STATUS OF AN EP PATENT APPLICATION OR GRANTED EP PATENT	EP
2025-05-21	INTG	INTENTION TO GRANT ANNOUNCED	EP
2025-07-09	GRAS	GRANT FEE PAID	EP
2025-07-11	GRAA	(EXPECTED) GRANT	EP
2025-07-11	STAA	INFORMATION ON THE STATUS OF AN EP PATENT APPLICATION OR GRANTED EP PATENT	EP
2025-07-18	TPAC	OBSERVATIONS FILED BY THIRD PARTIES	EP
2025-08-13	AK	DESIGNATED CONTRACTING STATES	EP
2025-08-15	REG	REFERENCE TO A NATIONAL CODE	EP
2025-08-13	REG	REFERENCE TO A NATIONAL CODE	EP
2025-08-28	REG	REFERENCE TO A NATIONAL CODE	EP
2025-09-10	REG	REFERENCE TO A NATIONAL CODE	EP
2025-10-15	U01	REQUEST FOR UNITARY EFFECT FILED	EP
2025-10-15	U07	UNITARY EFFECT REGISTERED	EP
2026-01-08	PG25	LAPSED IN A CONTRACTING STATE [ANNOUNCED VIA POSTGRANT INFORMATION FROM NATIONAL OFFICE TO EPO]	EP
2026-01-12	PG25	LAPSED IN A CONTRACTING STATE [ANNOUNCED VIA POSTGRANT INFORMATION FROM NATIONAL OFFICE TO EPO]	EP
2026-01-15	PG25	LAPSED IN A CONTRACTING STATE [ANNOUNCED VIA POSTGRANT INFORMATION FROM NATIONAL OFFICE TO EPO]	EP
2026-01-16	PG25	LAPSED IN A CONTRACTING STATE [ANNOUNCED VIA POSTGRANT INFORMATION FROM NATIONAL OFFICE TO EPO]	EP
2026-01-23	PG25	LAPSED IN A CONTRACTING STATE [ANNOUNCED VIA POSTGRANT INFORMATION FROM NATIONAL OFFICE TO EPO]	EP
2026-01-28	PG25	LAPSED IN A CONTRACTING STATE [ANNOUNCED VIA POSTGRANT INFORMATION FROM NATIONAL OFFICE TO EPO]	EP
2026-01-30	PG25	LAPSED IN A CONTRACTING STATE [ANNOUNCED VIA POSTGRANT INFORMATION FROM NATIONAL OFFICE TO EPO]	EP
2026-04-06	PG25	LAPSED IN A CONTRACTING STATE [ANNOUNCED VIA POSTGRANT INFORMATION FROM NATIONAL OFFICE TO EPO]	EP
2026-04-23	PG25	LAPSED IN A CONTRACTING STATE [ANNOUNCED VIA POSTGRANT INFORMATION FROM NATIONAL OFFICE TO EPO]	EP
2026-04-28	PG25	LAPSED IN A CONTRACTING STATE [ANNOUNCED VIA POSTGRANT INFORMATION FROM NATIONAL OFFICE TO EPO]	EP
2026-05-15	PLBI	OPPOSITION FILED	EP
2026-05-21	REG	REFERENCE TO A NATIONAL CODE	EP
2026-05-27	PLAX	NOTICE OF OPPOSITION AND REQUEST TO FILE OBSERVATION + TIME LIMIT SENT	EP
2026-06-17	26	OPPOSITION FILED	EP
2026-06-24	U20	RENEWAL FEE FOR THE EUROPEAN PATENT WITH UNITARY EFFECT PAID	EP
2026-09-25	PLBB	REPLY OF PATENT PROPRIETOR TO NOTICE(S) OF OPPOSITION RECEIVED	EP

Patent & Non-Patent Citations

Cited documents and prior art referenced in search and examination reports.

15 Citations

Cited Patent Documents

WO2016181342 2016-11-17

Espacenet

Non-Patent Scientific Literature (NPL)

- ANONYMOUS: "Drusenoff - eye drops against uv and blue light 10 ml", FARMACOSMO, 1 January 2026 (2026-01-01), XP093400022, Retrieved from the Internet <URL:https://www.farmacosmo.com/health-pharmacy/drusenoff-eye-drops-against-uv-and-blue-light-10-ml-098575/>

- MONTEFARMACO: "Iridina Lubricating Drops", 12 December 2019 (2019-12-12), XP055769721

- THIERRY PAULOIN, MéLODY DUTOT, FRANCINE JOLY, JEAN-MICHEL WARNET, PATRICE RAT: "High molecular weight hyaluronan decreases UVB-induced apoptosis and inflammation in human epithelial corneal cells", MOLECULAR VISION, MOLECULAR VISION, UNITED STATES, 1 January 2009 (2009-01-01), United States , pages 577 - 583, XP055602786, Retrieved from the Internet <URL:http://www.molvis.org/molvis/v15/a58/mv-v15-a58-pauloin.pdf>

- ANONYMOUS: "Blue light facts: Is blue light bad for your eyes?", ALL ABOUT VISION, 10 June 2023 (2023-06-10), XP093400025, Retrieved from the Internet <URL:https://www.allaboutvision.com/conditions/computer-vision-syndrome/blue-light/overview-of-blue-light/>

- PHARMACYLORETO.COM – OFTYVIT EYE DROPS – 5 ML, RETRIEVED ON 5 MAY 2026

- FARMACOSMO.COM – EXE DROPS ANTIOXIDANT NUTRITIVE OFTYVIT VIAL 5 ML, RETRIEVED ON 5 MAY 2026

- LEE HYO SEOK, CUI LIAN, LI YING, CHOI JI SUK, CHOI JOO-HEE, LI ZHENGRI, KIM GA EON, CHOI WON, YOON KYUNG CHUL: "Influence of Light Emitting Diode-Derived Blue Light Overexposure on Mouse Ocular Surface", PLOS ONE, PUBLIC LIBRARY OF SCIENCE, US, vol. 11, no. 8, 12 August 2016 (2016-08-12), US , pages e0161041, XP093400112, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0161041

- SOPHIA SEEN; LOUIS TONG: "Dry eye disease and oxidative stress", ACTA OPHTHALMOLOGICA: THE OPHTHALMOLOGICAL JOURNAL OF THE NORDIC COUNTRIES, WILEY-BLACKWELL MUNKSGAARD, DENMARK, vol. 96, no. 4, 21 August 2017 (2017-08-21), Denmark , pages e412 - e420, XP072398625, ISSN: 1755-375X, DOI: 10.1111/aos.13526

- ZHI-CHUN ZHAO, YING ZHOU, GANG TAN, JUAN LI: "Research progress about the effect and prevention of blue light on eyes", INTERNATIONAL JOURNAL OF OPHTHALMOLOGY, INTERNATIONAL COUNCIL OF OPHTHALMOLOGY, CN, 18 December 2018 (2018-12-18), CN , XP055615903, ISSN: 2222-3959, DOI: 10.18240/ijo.2018.12.20

- DYER J. M.: "Revealing The Unseen: A Review of Wood's Lamp in Dermatology", JOURNAL OF AESTHETIC DERMATOLOGY, vol. 15, no. 6, 1 January 2022 (2022-01-01), pages 25 - 30, XP093301332

- SESHADRI NEERVANNAN, UDAY B. KOMPELLA: "OPHTHALMIC PRODUCT DEVELOPMENT - FROM BENCH TO BEDSIDE", 8 February 2022, AAPS ; SPRINGER, ISBN: 978-3-030-76366-4, article IMRAN AHMED: "Physicochemical and Biological Fundamentals for Drug Delivery to the Eye", pages: 93 - 119, XP009567178, DOI: 10.1007/978-3-030-76367-1_5 * page 113 *

- SESHADRI NEERVANNAN, UDAY B. KOMPELLA: "", , ISBN: , PAGES: 113; 487: "OPHTHALMIC PRODUCT DEVELOPMENT - FROM BENCH TO BEDSIDE", 8 February 2022, AAPS ; SPRINGER, ISBN: 978-3-030-76366-4, article GITANJALI SHARMA, CHEN ZHOU, SAURABH WADHWA, ASHWIN C. PARENKY, KENNETH S. GRAHAM, AMARDEEP S. BHALLA ET AL.: "Ophthalmic Product Development for Biologics", pages: 463 - 509, XP009567179, DOI: 10.1007/978-3-030-76367-1_17 * page 487 *

- SHAPIRO ARON: "Understanding blue light - Exposure to certain wavelengths of blue light carries potential blinding effects and a link to AMD", RETINA TODAY, 1 April 2016 (2016-04-01), pages 22 - 23, XP093400121

- DEBBASCH CAROLINE ET AL: "Cytoprotective effects of hyaluronic acid and Carbomer 934P in ocular surface epithelial cells.", INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE - IOVS, ASSOCIATION FOR RESEARCH IN VISION AND OPHTHALMOLOGY - ARVO, vol. 43, no. 11, 1 November 2002 (2002-11-01), pages 3409 - 3415, XP002459409, ISSN: 0146-0404

Worldwide Patent Family

Related applications and patents in the same INPADOC worldwide family.

6 Family Members

Country	Publication Number	Kind	Publication Date	Action
EP	EP4157291A1	A1	2023-04-05	Espacenet
EP	EP4157291B1	B1	2025-08-13	Espacenet
EP	EP4157291C0	C0	2025-08-13	Espacenet
CN	CN115867292A	A	2023-03-28	Espacenet
IT	IT202000012535A1	A1	2021-11-27	Espacenet
WO	WO2021239544A1	A1	2021-12-02	Espacenet

Official File Inspection EPC Art. 128 Public Dossier

Complete European Patent Register Dossier (148 Total Documents)

The full inspection file for Application EP21726407 contains 148 total documents, including all notices of opposition, proprietor counter-statements, examination communications, third-party observations, and procedural forms. Below are all major recorded procedural filings and publication specifications.

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Date: 2026-01-30 Procedure: Examination 0009250

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OPHTHALMIC COMPOSITION BASED ON HYALURONIC ACID TO PROTECT FROM DAMAGES CAUSED BY ENVIRONMENTAL POLLUTION

Patent Abstract / Summary

IPC Classifications

Priority Claims

Designated Contracting States (38 EPC States)

Parties & Representation

Applicants

Inventors (2)

Representatives / Agents

Key Procedural Dates

Patent Oppositions

Maiwald GmbH

Legal Status & Event History

Patent & Non-Patent Citations

Cited Patent Documents

Non-Patent Scientific Literature (NPL)

Worldwide Patent Family

Complete European Patent Register Dossier (148 Total Documents)

Recorded Filings & Patent Specifications

European Patent Specification - Granted Patent (B1)

Official European Patent Register Full Dossier

European Patent Application with Search Report (A1)

New entry: Reply of patent proprietor to notice(s) of opposition

New entry: Communication of a notice of opposition and request to file observations + time limit

Invitation to proprietor to file observations on the notice of opposition

Opposition filed

Lapse of the patent in a contracting state

Lapse of the patent in a contracting state

Lapse of the patent in a contracting state

Lapse of the patent in a contracting state

Lapse of the patent in a contracting state

Lapse of the patent in a contracting state

Lapse of the patent in a contracting state

Lapse of the patent in a contracting state

New entry: Observations by third parties

Observations by a third party

(Expected) grant

New entry: Receipt of the translation of the claim(s)

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New entry: Renewal fee paid

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First examination report

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Amendments

New entry: Renewal fee paid

Renewal fee payment

Publication in section I.1 EP Bulletin

The date on which the examining division becomes responsible, has been established

Request for examination filed

PCT data prior to European publication

PCT data prior to European publication

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Payment of national basic fee

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