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METHODS FOR DIAGNOSING A CANCER- OR ANTIBIOTICS-INDUCED DYSBIOSIS AND THEIR USE FOR IMPROVING CANCER TREATMENT BY IMMUNOTHERAPY

Publication No. EP4359795

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App No. EP22735870

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Filed by Institut Gustave Roussy

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Filed on 2022-06-21

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Issued/Published on 2026-01-14

Official EPO Register

Publication No. EP4359795 A1

Application No. EP22735870 Filed: 2022-06-21

Grant Date 2026-01-14 Mention of grant

Active Oppositions 1 Active EPO Oppositions

Patent Abstract / Summary

Patent abstract is being processed or was not provided in English by the publishing office.

IPC Classifications

G01N33/569, G01N33/574, G01N33/68

Priority Claims

EP 20210305846 Date: 2021-06-21

EP 20210306817 Date: 2021-12-16

Designated Contracting States (38 EPC States)

AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

Parties & Representation

Applicants

Institut Gustave Roussy

39, rue Camille Desmoulins, 94800 Villejuif

Everimmune

39 Rue Camille Desmoulins, 94800 Villejuif

Université Paris-Saclay

Bâtiment Bréguet, 3 rue Joliot Curie

Institut National de la Santé et de la Recherche Médicale (INSERM)

101 rue de Tolbiac, 75013 Paris

Institut Gustave-Roussy

39, rue Camille Desmoulins, 94800 Villejuif

Inventors (4)

FIDELLE, Marine

75005 PARIS

ZITVOGEL, Laurence

75006 PARIS

DAILLERE, Romain

49100 ANGERS

RAUBER Conrad

69120 Heidelberg

Representatives / Agents

Casalonga

Casalonga & Partners, Sendlinger Straße 7

Stellbrink & Partner Patentanwälte mbB

Widenmayerstrasse 10, 80538 München

Key Procedural Dates

Request-For-Examination 2024-01-18

Mention Of Grant Published 2026-01-14

First-Examination-Report-Despatched 2024-11-21

Legal Status & Event History

Official European Patent Office legal and procedural status changes recorded for this file.

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Patent & Non-Patent Citations

Cited documents and prior art referenced in search and examination reports.

41 Citations

Cited Patent Documents

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US2007122404 2007-05-31

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WO2004081049 2004-09-23

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WO2005067620 2005-07-28

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WO2017165778 2017-09-28

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WO2004045542 2004-06-03

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WO2020106983 2020-05-28

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US2019113513 2019-04-18

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WO2020150208 2020-07-23

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Non-Patent Scientific Literature (NPL)

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- GAO RACHEL Y ET AL: "Bile acids modulate colonic MAdCAM-1 expression in a murine model of combined cholestasis and colitis", MUCOSAL IMMUNOLOGY, vol. 14, no. 2, pages 479 - 490, XP037402033, ISSN: 1933-0219, DOI: 10.1038/S41385-020-00347-6

- WANG RUI ET AL: "Gut microbiome, liver immunology, and liver diseases", CELLULAR & MOLECULAR IMMUNOLOGY, vol. 18, no. 1, pages 4 - 17, XP037326144, ISSN: 1672-7681, DOI: 10.1038/S41423-020-00592-6

- GOUBET ANNE-GA�LLE ET AL: "Multifaceted modes of action of the anticancer probiotic Enterococcus hirae", CELL DEATH & DIFFERENTIATION, NATURE PUBLISHING GROUP, GB, vol. 28, no. 7, 11 May 2021 (2021-05-11), pages 2276 - 2295, XP037500593, ISSN: 1350-9047, [retrieved on 20210511], DOI: 10.1038/S41418-021-00753-8

- S. VIAUD ET AL: "The Intestinal Microbiota Modulates the Anticancer Immune Effects of Cyclophosphamide", SCIENCE, vol. 342, no. 6161, 21 November 2013 (2013-11-21), pages 971 - 976, XP055108615, ISSN: 0036-8075, DOI: 10.1126/science.1240537

- AL-RASHIDI HANAN E.: "Gut microbiota and immunity relevance in eubiosis and dysbiosis", SAUDI JOURNAL OF BIOLOGICAL SCIENCES, vol. 29, no. 3, 1 March 2022 (2022-03-01), AMSTERDAM, NL, pages 1628 - 1643, XP055922849, ISSN: 1319-562X, DOI: 10.1016/j.sjbs.2021.10.068

- ZHAO YANG ET AL: "The Tumour Vasculature as a Target to Modulate Leucocyte Trafficking", CANCERS, vol. 13, no. 7, 6 April 2021 (2021-04-06), pages 1724, XP055922851, DOI: 10.3390/cancers13071724

- LIU FANG ET AL: "Dysbiosis of the Gut Microbiome is associated with Tumor Biomarkers in Lung Cancer", INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, vol. 15, no. 11, 1 January 2019 (2019-01-01), pages 2381 - 2392, XP055923677, ISSN: 1449-2288, Retrieved from the Internet <URL:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6775324/pdf/ijbsv15p2381.pdf> DOI: 10.7150/ijbs.35980

- YANG XINYU ET AL: "The Gut-liver Axis in Immune Remodeling: New insight into Liver Diseases", INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, vol. 16, no. 13, 1 January 2020 (2020-01-01), pages 2357 - 2366, XP055923304, ISSN: 1449-2288, DOI: 10.7150/ijbs.46405

- DEROSA LISA ET AL: "Gut Bacteria Composition Drives Primary Resistance to Cancer Immunotherapy in Renal Cell Carcinoma Patients", EUROPEAN UROLOGY, ELSEVIER, AMSTERDAM, NL, vol. 78, no. 2, 4 May 2020 (2020-05-04), pages 195 - 206, XP086222713, ISSN: 0302-2838, [retrieved on 20200504], DOI: 10.1016/J.EURURO.2020.04.044

- EUPHEMIA LEUNG ET AL: "Mucosal vascular addressin cell adhesion molecule-1 is expressed outside the endothelial lineage on fibroblasts and melanoma cells", IMMUNOLOGY AND CELL BIOLOGY, vol. 81, no. 4, 1 August 2003 (2003-08-01), pages 320 - 327, XP055145434, ISSN: 0818-9641, DOI: 10.1046/j.1440-1711.2003.t01-1-01175.x

- PORTER ROSS J ET AL: "Inflammatory Bowel Disease-Associated Colorectal Cancer: Translational Risks from Mechanisms to Medicines", JOURNAL OF CROHN'S AND COLITIS, vol. 15, no. 12, 18 December 2021 (2021-12-18), NL, pages 2131 - 2141, XP055922806, ISSN: 1873-9946, Retrieved from the Internet <URL:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8684457/pdf/jjab102.pdf> DOI: 10.1093/ecco-jcc/jjab102

- YUAN TIAN1 ET AL: "TRIM59 loss in M2 macrophages promotes melanoma migration and invasion by upregulating MMP-9 and Madcam1", AGING, 10 October 2019 (2019-10-10), pages 8623 - 8641, XP055924631, Retrieved from the Internet <URL:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6814609/pdf/aging-11-102351.pdf> [retrieved on 20220524]

- DOGAN AHMET ET AL: "Copyright American Societyfor Investigative Pathology Expression of Lymphocyte Homing Receptors and Vascular Addressins in Low-Grade Gastric B-Cell Lymphomas of Mucosa-Associated Lymphoid Tissue", AMERICAN JOURNAL OFPATHOLOGY, 1 November 1997 (1997-11-01), pages 1361 - 1369, XP055923310, Retrieved from the Internet <URL:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1858078/pdf/amjpathol00023-0182.pdf> [retrieved on 20220519]

- LEUNG EUPHEMIA ET AL: "Bioassay detects soluble MAdCAM-1 in body fluids", IMMUNOLOGY AND CELL BIOLOGY, CARLTON, AU, vol. 82, no. 4, 1 August 2004 (2004-08-01), pages 400 - 409, XP002417044, ISSN: 0818-9641, DOI: 10.1111/J.0818-9641.2004.01247.X

- BERTRAND ROUTY; EMMANUELLE LE CHATELIER; LISA DEROSA; CONNIE P M DUONG; MARYAM TIDJANI ALOU; ROMAIN DAILL�RE; AUR�LIE FLUCKIGER; M: "Gut microbiome influences efficacy of PD-1-based immunotherapy against epithelial tumors", SCIENCE, vol. 359, no. 6371, 5 January 2018 (2018-01-05), US, pages 91 - 97, XP055554928, ISSN: 0036-8075, DOI: 10.1126/science.aan3706

- TRIVEDI PALAK J. ET AL: "Vascular adhesion protein-1 is elevated in primary sclerosing cholangitis, is predictive of clinical outcome and facilitates recruitment of gut-tropic lymphocytes to liver in a substrate-dependent manner", CANCER GENETICS AND CYTOGENETICS., 20 April 2017 (2017-04-20), US, pages 1 - 11, XP055922843, ISSN: 0165-4608, Retrieved from the Internet <URL:https://gut.bmj.com/content/gutjnl/early/2017/04/20/gutjnl-2016-312354.full.pdf> DOI: 10.1016/S0165-4608(98)00200-3

- SHARPTON S R ET AL: "Current Concepts, Opportunities, and Challenges of Gut Microbiome-Based Personalized Medicine in Nonalcoholic Fatty Liver Disease", CELL METABOLISM, CELL PRESS, UNITED STATES, vol. 33, no. 1, 8 December 2020 (2020-12-08), pages 21 - 32, XP086436257, ISSN: 1550-4131, [retrieved on 20201208], DOI: 10.1016/J.CMET.2020.11.010

- JAIN TEJESHWAR ET AL: "New Insights Into the Cancer-Microbiome-Immune Axis: Decrypting a Decade of Discoveries", FRONTIERS IN IMMUNOLOGY, vol. 12, 23 February 2021 (2021-02-23), XP055922850, DOI: 10.3389/fimmu.2021.622064

[PXY] - DEROSA LISA ET AL: "Microbiota-Centered Interventions: The Next Breakthrough in Immuno-Oncology?", CANCER DISCOVERY, vol. 11, no. 10, 1 October 2021 (2021-10-01), US, pages 2396 - 2412, XP055925491, ISSN: 2159-8274, Retrieved from the Internet <URL:https://aacrjournals.org/cancerdiscovery/article-pdf/11/10/2396/3082580/2396.pdf> DOI: 10.1158/2159-8290.CD-21-0236

- BARUCH EREZ N., YOUNGSTER ILAN, BEN-BETZALEL GUY, ORTENBERG RONA, LAHAT ADI, KATZ LIOR, ADLER KATERINA, DICK-NECULA DANIELA, RASKI: "Fecal microbiota transplant promotes response in immunotherapy-refractory melanoma patients", SCIENCE, vol. 371, no. 6529, 1 February 2021 (2021-02-01), US , pages 602 - 609, XP093446730, ISSN: 0036-8075, DOI: 10.1126/science.abb5920

- DAVAR DIWAKAR, DZUTSEV AMIRAN K., MCCULLOCH JOHN A., RODRIGUES RICHARD R., CHAUVIN JOE-MARC, MORRISON ROBERT M., DEBLASIO RICHELLE: "Fecal microbiota transplant overcomes resistance to anti–PD-1 therapy in melanoma patients", SCIENCE, vol. 371, no. 6529, 5 February 2021 (2021-02-05), US , pages 595 - 602, XP055938683, ISSN: 0036-8075, DOI: 10.1126/science.abf3363

- BERTRAND ROUTY, EMMANUELLE LE CHATELIER, LISA DEROSA, CONNIE P. M. DUONG, MARYAM TIDJANI ALOU, ROMAIN DAILLèRE, AURéLIE : "Gut microbiome influences efficacy of PD-1–based immunotherapy against epithelial tumors", SCIENCE, vol. 359, no. 6371, 5 January 2018 (2018-01-05), US , pages 91 - 97, XP055527737, ISSN: 0036-8075, DOI: 10.1126/science.aan3706

- DEROSA LISA, ROUTY BERTRAND, DESILETS ANTOINE, DAILLÈRE ROMAIN, TERRISSE SAFAE, KROEMER GUIDO, ZITVOGEL LAURENCE: "Microbiota-Centered Interventions: The Next Breakthrough in Immuno-Oncology?", CANCER DISCOVERY, vol. 11, no. 10, 1 October 2021 (2021-10-01), US , pages 2396 - 2412, XP055925491, ISSN: 2159-8274, DOI: 10.1158/2159-8290.CD-21-0236

- HOLMER ARIELA K., BATTAT ROBERT, DULAI PARAMBIR S., VANDE CASTEELE NIELS, NGUYEN NGHIA, JAIN ANJALI, MIRALLES ARA, NEILL JENNIFER,: "Biomarkers are associated with clinical and endoscopic outcomes with vedolizumab treatment in Crohn’s disease", THERAPEUTIC ADVANCES IN GASTROENTEROLOGY, vol. 13, 1 January 2020 (2020-01-01), pages 1 - 13, XP093446738, ISSN: 1756-2848, DOI: 10.1177/1756284820971214

- D9 - Written Opinion of the International Searching Authority for PCT/EP2022/066929 (EPO as ISA) on file

- PORTER ROSS J, ARENDS MARK J, CHURCHHOUSE ANTONIA M D, DIN SHAHIDA: "Inflammatory Bowel Disease-Associated Colorectal Cancer: Translational Risks from Mechanisms to Medicines", JOURNAL OF CROHN'S AND COLITIS, vol. 15, no. 12, 18 December 2021 (2021-12-18), pages 2131 - 2141, XP055922806, ISSN: 1873-9946, DOI: 10.1093/ecco-jcc/jjab102

- LIU CHAO, LIU RUIQI, WANG BOJUN, LIAN JIE, YAO YANG, SUN HAOXIU, ZHANG CHUNHUI, FANG LIN, GUAN XIN, SHI JIAQI, HAN SHULING, ZHAN F: "Blocking IL-17A enhances tumor response to anti-PD-1 immunotherapy in microsatellite stable colorectal cancer", JOURNAL FOR IMMUNOTHERAPY OF CANCER, vol. 9, no. 1, 1 January 2021 (2021-01-01), GB , pages e001895 - e001895-14, XP093446740, ISSN: 2051-1426, DOI: 10.1136/jitc-2020-001895

Worldwide Patent Family

Related applications and patents in the same INPADOC worldwide family.

13 Family Members

Country	Publication Number	Kind	Publication Date	Action
EP	EP4359795A1	A1	2024-05-01	Espacenet
EP	EP4359795B1	B1	2026-01-14	Espacenet
EP	EP4359795C0	C0	2026-01-14	Espacenet
AU	AU2022297690A1	A1	2024-02-08	Espacenet
CA	CA3223488A1	A1	2022-12-29	Espacenet
CN	CN118202247A	A	2024-06-14	Espacenet
ES	ES3066614T3	T3	2026-05-13	Espacenet
IL	IL309631A	A	2024-02-01	Espacenet
JP	JP2024529254A	A	2024-08-06	Espacenet
KR	KR20240032857A	A	2024-03-12	Espacenet
US	US20240288449A1	A1	2024-08-29	Espacenet
WO	WO2022268841A1	A1	2022-12-29	Espacenet
WO	WO2022268841A9	A9	2023-03-09	Espacenet

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METHODS FOR DIAGNOSING A CANCER- OR ANTIBIOTICS-INDUCED DYSBIOSIS AND THEIR USE FOR IMPROVING CANCER TREATMENT BY IMMUNOTHERAPY

Patent Abstract / Summary

IPC Classifications

Priority Claims

Designated Contracting States (38 EPC States)

Parties & Representation

Applicants

Inventors (4)

Representatives / Agents

Key Procedural Dates

Patent Oppositions

mbiomics GmbH

Legal Status & Event History

Patent & Non-Patent Citations

Cited Patent Documents

Non-Patent Scientific Literature (NPL)

Worldwide Patent Family

Complete European Patent Register Dossier (148 Total Documents)

Recorded Filings & Patent Specifications

European Patent Specification - Granted Patent (B1)

Official European Patent Register Full Dossier

European Patent Application with Search Report (A1)

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