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COMPOSITIONS AND METHODS FOR ANALYTE DETECTION

Publication No. EP4491741

•

App No. EP24195205

•

Filed by President And Fellows Of Harvard College

•

Filed on 2012-12-21

•

Issued/Published on 2025-10-15

Official EPO Register

Publication No. EP4491741 A2

Application No. EP24195205 Filed: 2012-12-21

Grant Date 2025-10-15 Mention of grant

Active Oppositions 2 Active EPO Oppositions

Patent Abstract / Summary

[0001] The inventions provided herein relate to detection reagents, compositions, methods, and kits comprising the detection reagents for use in detection, identification, and/or quantification of analytes in a sample. Such detection reagents and methods described herein allow multiplexing of many more labeled species in the same procedure than conventional methods, in which multiplexing is limited by the number of available and practically usable colors.

IPC Classifications

C12Q1/6804, C12Q1/6816, C12N15/11, G01N33/68, G01N33/532, G01N33/53 C12Q1/6816

Priority Claims

US 201161579265P Date: 2011-12-22

Designated Contracting States (38 EPC States)

AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

Parties & Representation

Applicants

President And Fellows Of Harvard College

17 Quincy Street, Cambridge, Massachusetts 02138

Inventors (4)

LEVNER, Daniel

Boston, 02115

LEE, Jehyuk

Allston, 02134

CHURCH, George, M.

Brookline, 02446

SUPER, Michael

Lexington, 02421

Representatives / Agents

Keltie LLP

No. 1 London Bridge, London SE1 9BA

Grosch, Marcus, et al

Quinn Emanuel Urquhart & Sullivan, LLP, Mollstrasse 42

Key Procedural Dates

Request-For-Examination 2025-03-26

Mention Of Grant Published 2025-10-15

First-Examination-Report-Despatched 2025-05-14

Patent Oppositions

Official opposition proceedings filed against European Patent EP4491741 under EPC Article 99.

2 ACTIVE OPPONENTS

Opponent Company

Element Biosciences Netherlands B.V.

Kreizersgracht 391-A, NL

Representative

Grosch, Marcus, et al

Filing Date

2026-07-15

Opposition in Progress

Opponent Company

Element Biosciences, Inc.

9880 Campus Point Drive, Suite 210, US

Representative

Grosch, Marcus, et al

Filing Date

2026-08-07

Opposition in Progress

Legal Status & Event History

Official European Patent Office legal and procedural status changes recorded for this file.

46 Events Recorded

Date	Code	Event Description	Auth
2025-01-15	AC	DIVISIONAL APPLICATION: REFERENCE TO EARLIER APPLICATION	EP
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2026-08-19	26	OPPOSITION FILED	EP
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US	US20250179557A1	A1	2025-06-05	Espacenet
US	US20260250739A1	A1	2026-08-27	Espacenet
US	US20260250740A1	A1	2026-08-27	Espacenet
WO	WO2013096851A1	A1	2013-06-27	Espacenet
WO	WO2014163886A1	A1	2014-10-09	Espacenet

Official File Inspection EPC Art. 128 Public Dossier

Complete European Patent Register Dossier (148 Total Documents)

The full inspection file for Application EP24195205 contains 148 total documents, including all notices of opposition, proprietor counter-statements, examination communications, third-party observations, and procedural forms. Below are all major recorded procedural filings and publication specifications.

Open 148-Doc Register Dossier

Recorded Filings & Patent Specifications

Official publication specifications, opposition filings, proprietor replies, and procedural submissions.

38 Filings Listed

European Patent Specification - Granted Patent (B1)

Publication Specification

Date: 2025-10-15 Procedure: Grant EP4491741B1

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Official European Patent Register Full Dossier

Publication Specification

Date: 2025-10-15 Procedure: All Proceedings (Examination & Opposition) EP24195205

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European Search Report (A3)

Publication Specification

Date: 2025-03-19 Procedure: Publication EP4491741A3

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European Patent Application without Search Report (A2)

Publication Specification

Date: 2025-01-15 Procedure: Publication EP4491741A2

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Communication of observations of proprietor

Procedural Step

Date: 2026-09-07 Procedure: Examination DOBS

Inspect on Register

New entry: Despatch of observations of proprietor to parties involved + time limit

Dossier Filing

Date: 2026-09-06 Procedure: Examination EPIDOSNDOB2

Inspect on Register

Lapse of the patent in a contracting state

Dossier Filing

Date: 2026-08-28 Procedure: Examination 0009250

Inspect on Register

Intervention admissible

Dossier Filing

Date: 2026-08-14 Procedure: Examination 0009266

Inspect on Register

Lapse of the patent in a contracting state

Dossier Filing

Date: 2026-07-31 Procedure: Examination 0009250

Inspect on Register

New entry: Communication of a notice of opposition and request to file observations + time limit

Dossier Filing

Date: 2026-07-27 Procedure: Opposition EPIDOSNOBS2

Inspect on Register

Invitation to proprietor to file observations on the notice of opposition

Procedural Step

Date: 2026-07-27 Procedure: Opposition OBSO

Inspect on Register

Lapse of the patent in a contracting state

Dossier Filing

Date: 2026-07-24 Procedure: Examination 0009250

Inspect on Register

COMPOSITIONS AND METHODS FOR ANALYTE DETECTION

Patent Abstract / Summary

IPC Classifications

Priority Claims

Designated Contracting States (38 EPC States)

Parties & Representation

Applicants

Inventors (4)

Representatives / Agents

Key Procedural Dates

Patent Oppositions

Element Biosciences Netherlands B.V.

Element Biosciences, Inc.

Legal Status & Event History

Patent & Non-Patent Citations

Cited Patent Documents

Non-Patent Scientific Literature (NPL)

Worldwide Patent Family

Complete European Patent Register Dossier (148 Total Documents)

Recorded Filings & Patent Specifications

European Patent Specification - Granted Patent (B1)

Official European Patent Register Full Dossier

European Search Report (A3)

European Patent Application without Search Report (A2)

Communication of observations of proprietor

New entry: Despatch of observations of proprietor to parties involved + time limit

Lapse of the patent in a contracting state

Intervention admissible

Lapse of the patent in a contracting state

New entry: Communication of a notice of opposition and request to file observations + time limit

Invitation to proprietor to file observations on the notice of opposition

Lapse of the patent in a contracting state

Change - opposition data/opponent's data or that of the opponent's representative

Lapse of the patent in a contracting state

Opposition filed

Lapse of the patent in a contracting state

Change - divisional application(s)

(Expected) grant

New entry: Receipt of the translation of the claim(s)

New entry: Payment of fee for grant

New entry: Payment of fee for publishing/printing

Intention to grant the patent

New entry: Communication of intention to grant a patent

Amendment by applicant

The date on which the examining division becomes responsible, has been established

Request for examination filed

Date on which the examining division has become responsible

Amendments

Change - classification

Publication of search report

New entry: Renewal fee paid

Renewal fee payment

Publication in section I.1 EP Bulletin

New entry: Renewal fee paid

Renewal fee payment

Change - representative

Language of the procedure

International searching authority