The patent has been granted The patent has been granted, Grant of patent is intended, Request for examination was made, The application has been published EP Register Verified

DETECTION AND TREATMENT OF DISEASE EXHIBITING DISEASE CELL HETEROGENEITY AND SYSTEMS AND METHODS FOR COMMUNICATING TEST RESULTS

Publication No. EP4574996

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App No. EP25155747

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Filed by Guardant Health, Inc.

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Filed on 2015-12-28

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Issued/Published on 2025-11-05

Official EPO Register

Publication No. EP4574996 A2

Application No. EP25155747 Filed: 2015-12-28

Grant Date 2025-11-05 Mention of grant

Active Oppositions 1 Active EPO Oppositions

Patent Abstract / Summary

This disclosure provides, among other things, methods for generating and applying therapeutic interventions. The methods involve, for example, (a) sequencing polynucleotides from cancer cells from a subject; (b) identifying and quantifying somatic mutations in the polynucleotides; (c) developing a profile of tumor heterogeneity in the subject indicating the presence and relative quantity of a plurality of the somatic mutations in the polynucleotides, wherein different relative quantities indicates tumor heterogeneity; and (d) determining a therapeutic intervention for a cancer exhibiting the tumor heterogeneity, wherein the therapeutic intervention is effective against a cancer having the profile of tumor heterogeneity determined.

IPC Classifications

C12Q1/68, C12N15/11, C12Q1/6869 C12Q1/6869

Priority Claims

US 201462098426P Date: 2014-12-31

US 201562155763P Date: 2015-05-01

Designated Contracting States (38 EPC States)

AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

Parties & Representation

Applicants

Guardant Health, Inc.

3100 Hanover Street, Palo Alto, CA 94304

Inventors (4)

ELTOUKHY, Helmy

Atherton, 94027

TALASAZ, AmirAli

Menlo Park, 94025

KERMANI, Bahram Ghaffarzadeh

Los Altos, 94022

IHUEGBU, Nnamdi

San Francisco, 94107

Representatives / Agents

Carpmaels & Ransford LLP

One Southampton Row, London WC1B 5HA

IK-IP LTD

8 Devonshire Square, London EC2M 4YJ

Key Procedural Dates

Request-For-Examination 2025-07-23

Mention Of Grant Published 2025-11-05

First-Examination-Report-Despatched 2025-08-22

Legal Status & Event History

Official European Patent Office legal and procedural status changes recorded for this file.

47 Events Recorded

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2025-05-23	STAA	INFORMATION ON THE STATUS OF AN EP PATENT APPLICATION OR GRANTED EP PATENT	EP
2025-07-16	RIC1	INFORMATION PROVIDED ON IPC CODE ASSIGNED BEFORE GRANT	EP
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2025-07-25	STAA	INFORMATION ON THE STATUS OF AN EP PATENT APPLICATION OR GRANTED EP PATENT	EP
2025-08-27	17P	REQUEST FOR EXAMINATION FILED	EP
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2025-08-22	STAA	INFORMATION ON THE STATUS OF AN EP PATENT APPLICATION OR GRANTED EP PATENT	EP
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2025-10-03	GRAA	(EXPECTED) GRANT	EP
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2025-11-05	AC	DIVISIONAL APPLICATION: REFERENCE TO EARLIER APPLICATION	EP
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2026-09-09	26	OPPOSITION FILED	EP
2026-09-16	R26	OPPOSITION FILED (CORRECTED)	EP

Patent & Non-Patent Citations

Cited documents and prior art referenced in search and examination reports.

39 Citations

Cited Patent Documents

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Complete European Patent Register Dossier (148 Total Documents)

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DETECTION AND TREATMENT OF DISEASE EXHIBITING DISEASE CELL HETEROGENEITY AND SYSTEMS AND METHODS FOR COMMUNICATING TEST RESULTS

Patent Abstract / Summary

IPC Classifications

Priority Claims

Designated Contracting States (38 EPC States)

Parties & Representation

Applicants

Inventors (4)

Representatives / Agents

Key Procedural Dates

Patent Oppositions

Sophia Genetics S.A.

Legal Status & Event History

Patent & Non-Patent Citations

Cited Patent Documents

Non-Patent Scientific Literature (NPL)

Worldwide Patent Family

Complete European Patent Register Dossier (148 Total Documents)

Recorded Filings & Patent Specifications

European Patent Specification - Granted Patent (B1)

Official European Patent Register Full Dossier

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