Ajinomoto Co., Inc. vs. AbTis Co., Ltd.

Explore the PTAB proceeding IPR2025-00283 filed by Ajinomoto Co., Inc. on 2024-12-24. This includes filing dates, application numbers, tech centers, patent numbers, and current case status.

Proceeding Overview

Proceeding Number

IPR2025-00283

Filing Date

2024-12-24

Accorded Filing Date

2024-12-24

Institution Decision Date

2025-08-08

Last Modified Date

2026-09-08

Proceeding Type

IPR

Termination Date

2026-08-03

Trial Status

Pending Director Review

Parties & Counsel

Petitioner

Ajinomoto Co., Inc.

Represented By

Maebius, Stephenet al

Patent Owner / Respondent

AbTis Co., Ltd.

Represented By

Engel, Jasonet al

Tribunal & Venue

Tribunal

Patent Trial and Appeal Board (USPTO)

Technology Center

TC 1600 - Biotechnology & Organic Chemistry

Patent Information

1 Patent Involved

Respondent Application Number 18154998

Respondent Patent Number 11896675

External Links

Espacenet

Google Patents

Respondent Inventor Sang Jeon CHUNG et al

Respondent Tech Center TC 1600 - Biotechnology & Organic Chemistry

Address and Attorney/Agent Information

19 Registered Practitioners

Power of Attorney & Correspondence

Firm / Entity Name K&L Gates LLP

Customer Number 45200

Address P.O. BOX 1135, CHICAGO, IL, 60690-1135, UNITED STATES

Attorney / Agent Information

Reg #	Name	Phone
39645	Louis Cullman	949-253-0900
40895	H. Anderton Jr.	650-353-0615
47893	Andrew Reibman	212-536-4074
51306	Mincheol Kim	949-721-5290
51654	Jason Engel	312-807-4236
54124	Michelle Bergman	949-253-0900
55819	Aaron Morrow	312-781-6043
57034	Hal Gibson	949-253-0900
61165	Kiran Sahasrabudhe	949-623-3534
62340	Brian Novak	949-253-0900
65578	Dennis Majewski	312-807-4329
69777	Giorgios Kefallinos	949-253-0900
72671	Kevin Mccormick	312-807-4335
74474	Benjamin Heuberger	949-623-3609
74880	Shu Chen	202-778-9053
76212	William Fortunato	336-698-4285
77309	David Old	949-202-1905
78399	Ye Eun Park	202-375-9485
79379	Hyoung Gook Lee	617-395-7070

Proceeding Documents

121

Authorized Response to Director Review Request OTHER

2026-09-08 FILING PARTY: PATENT OWNER

Download

2014

Ex. 2014 - Board's May 11, 2026 Email regarding Supplemental Briefing Exhibit

2026-09-08 FILING PARTY: PATENT OWNER

Download

Patent Owner's Updated Exhibit List NOTICE

2026-09-08 FILING PARTY: PATENT OWNER

Download

Petitioner’s Request for Director Review of Final Written Decision REQUEST

2026-08-31 FILING PARTY: PETITIONER

Download

3100

Email, Subject_IPR2025-00283 Director Review Request Exhibit

2026-08-31 FILING PARTY: BOARD

Download

Ajinomoto Co., Inc. vs. AbTis Co., Ltd.

Proceeding Overview

Parties & Counsel

Petitioner

Ajinomoto Co., Inc.

Represented By

Patent Owner / Respondent

AbTis Co., Ltd.

Represented By

Tribunal & Venue

Patent Information

Address and Attorney/Agent Information

Power of Attorney & Correspondence

Attorney / Agent Information

Proceeding Documents

Authorized Response to Director Review Request OTHER

Ex. 2014 - Board's May 11, 2026 Email regarding Supplemental Briefing Exhibit

Patent Owner's Updated Exhibit List NOTICE

Petitioner’s Request for Director Review of Final Written Decision REQUEST

Email, Subject_IPR2025-00283 Director Review Request Exhibit

Judgment Final Written Decision FINAL

Other: Hearing transcript OTHER

Petitioner’s Supplemental Letter Brief OTHER

Patent Owner's Supplemental Brief OTHER

Petitioner's Demonstratives Exhibit

Patent Owner's Updated Exhibit List NOTICE

Ex. 2013 - Patent Owner's Demonstratives Exhibit

Petitioner's Updated Exhibit List NOTICE

Patent Owner's LEAP Request GRANTED (Anna Rebekah Hill) NOTICE

Petitioner’s Reply to Opposition to Motion to Exclude REPLY

Petitioner’s Opposition to Motion to Submit Supplemental Evidence OPPOSITION

Ex. 2012 - Second Declaration of Dr. Zhou, corrected April 20, 2026 Exhibit

Patent Owner's Motion to Submit Supplemental Evidence MOTION

Patent Owner's Opposition to Petitioner's Motion to Exclude OPPOSITION

Patent Owner's Updated Exhibit List NOTICE

Petitioner’s Sur-Reply to Patent Owner’s Motion to Amend OPPOSITION

Petitioner’s Motion to Exclude MOTION

Order: Setting Oral Argument ORDER

Petitioner's Request for Oral Argument OTHER

Patent Owner's Request for Oral Argument OTHER

Petitioner’s Objections to Patent Owner’s Evidence Submitted with Patent Owner’s Reply To Petitioner’s Opposition to Patent Owner’s Motion to Amend OTHER

Ex. 2010 - Zeitschrift für Chemie Exhibit

Ex. 2009 - English Translation of Kirmse et al. Exhibit

Patent Owner's Reply to Petitioner's Opposition to Motion to Amend REPLY

Ex. 2008 - Second Declaration of Dr. Zhou Exhibit

Order: Preliminary Guidance on Motion to Amend ORDER

Tumey et al., Site Selection: a Case Study in the Identification of Optimal Cysteine Engineered Antibody Drug Conjugates, AAPS JOURNAL, 2017, 19(4):1123- 1135 Exhibit

Second Declaration of Dr. Lawrence Nathan Tumey Exhibit

Oliveira et al., Inverse electron demand Diels–Alder reactions in chemical biology, CHEMICAL SOCIETY REVIEWS, 2017, 46(16): 4895-4950 Exhibit

Pickens et al., Practical Considerations, Challenges, and Limitations of Bioconjugation via Azide–Alkyne Cycloaddition, BIOCONJUGATE CHEMISTRY, 2017, 29(3): 686-701 Exhibit

Mullapudi et al., Resin-Supported Site-Specific Antibody Conjugation Method Leads to Antibody-Drug Conjugates with Retained Efficacy and Improved Stability, BIOCONJUGATE CHEMISTRY, 2025, 36: 1956- 1969 Exhibit

Lyon et al., Self-hydrolyzing maleimides improve the stability and pharmacological properties of antibodydrug conjugates, NATURE BIOTECHNOLOGY, 2014, 32: 1059-1062 Exhibit

Oller-Salvia et al., Rapid and Efficient Generation of Stable Antibody–Drug Conjugates via an Encoded Cyclopropene and an Inverse‐Electron‐Demand Diels–Alder Reaction, ANGEW CHEM INT ED ENGL., 2018, 57(11): 2831-2834 Exhibit

Petitioner’s Opposition to Patent Owner’s Motion to Amend OPPOSITION

Deposition Transcript of Dr. Zhaohui Sunny Zhou Exhibit

Benjamin et al., Thiolation of Q295: Site-Specific Conjugation of Hydrophobic Payloads without the Need for Genetic Engineering, MOLECULAR PHARMACEUTICS, 2019, 16(6): 2795-2807 Exhibit

Knight et al., Synthesis and evaluation of an 18Flabaelled norbornene derivative for copper-free click chemistry reaction, ORGANIC & BIOMOLECULAR CHEMISTRY, 2013, 11: 3817-3825 Exhibit

Petitioner’s Updated Exhibit List NOTICE

Graziani et al., PF-06804103, A Site-specific Anti-HER2 Antibody–Drug Conjugate for the Treatment of HER2- expressing Breast, Gastric, and Lung Cancers, MOLECULAR CANCER THERAPEUTICS, 2020, 19, 10, 2068-2078 Exhibit

Sadiki et al., Site-specific conjugation of native antibodies, ANTIBODY THERAPEUTICS, 2020, 3(4):271- 284 Exhibit

Chalker et al., Methods for converting cysteine to dehydroalanine on peptides and proteins, CHEMICAL SCIENCE, 2011, 2: 1666-1676 Exhibit

Chau et al., Antibody–drug conjugates for cancer, THE LANCET, 2019, 394(10200): 793-804 Exhibit

Jain et al., Current ADC Linker Chemistry, PHARMACEUTICAL RESEARCH, 2015, 32: 3526-3540 Exhibit

Lyon et al., Reducing hydrophobicity of homogeneous antibody-drug conjugates improves pharmacokinetics and therapeutic index, NATURE BIOTECHNOLOGY, 2015, 33: 733-735 Exhibit

Tumey et al., Optimization of Tubulysin Antibody–Drug Conjugates: A Case Study in Addressing ADC Metabolism, ACS MEDICINAL CHEMISTRY LETTERS, 2016, 7(11): 977-982 Exhibit

Trail et al., Antibody drug conjugates for treatment of breast cancer: Novel targets and diverse approaches in ADC design, PHARMACOLOGY & THERAPEUTICS, 2018, 181: 126-142 Exhibit

Kirmse et al., Destabilisierte 2-Norbornyl-Kationen, ANGEWANDTE CHEMIE, 1985, 97(1): 51-52 Exhibit

Staudacher & Brown, Antibody drug conjugates and bystander killing: is antigen-dependent internalisation required?, BRITISH JOURNAL OF CANCER, 2017, 117: 1736-1742 Exhibit

Petitioner’s Notice of Deposition of Zhaohui Sunny Zhou, PH.D. NOTICE

Ex. 2002 - U.S. Patent App. No. 18/154,998 Exhibit

Ex. 2004 - Declaration of Dr. Zhaohui Sunny Zhou Exhibit

Ex. 2005 - Curriculum Vitae of Dr. Zhaohui Sunny Zhou Exhibit

Patent Owner's Non-Contingent Motion to Amend Under 37 C.F.R. § 42.121 MOTION

Ex. 2003 - U.S. Patent App. No. 16/980,503 Exhibit

Ex. 2006 - Deposition Transcript of Dr. Tumey Exhibit

Patent Owner's Updated Mandatory Notices NOTICE

Patent Owner's Notice of Remote Deposition of Dr. Lawrence N. Tumey NOTICE

ORDER Granting-in-Part and Denying-in-Part Patent Owner’s Motion for Withdrawal and Substitution of Counsel 37 C.F.R. § 42.10 ORDER

Petitioner's Updated Mandatory Notices NOTICE

General Order: Related Matters Updates ORDER