Tempus AI, Inc. vs. Guardant Health Inc.

Explore the PTAB proceeding IPR2025-01434 filed by Tempus AI, Inc. on 2025-08-15. This includes filing dates, application numbers, tech centers, patent numbers, and current case status.

Proceeding Overview

Proceeding Number

IPR2025-01434

Filing Date

2025-08-15

Accorded Filing Date

2025-08-15

Institution Decision Date

2025-12-18

Last Modified Date

2026-01-21

Proceeding Type

IPR

Termination Date

2025-12-18

Trial Status

Discretionary Denial

Parties & Counsel

Petitioner

Tempus AI, Inc.

Represented By

Glass, Jameset al

Patent Owner / Respondent

Guardant Health Inc.

Represented By

Rosato, Michaelet al

Tribunal & Venue

Tribunal

Patent Trial and Appeal Board (USPTO)

Technology Center

TC 1600 - Biotechnology & Organic Chemistry

Patent Information

1 Patent Involved

Respondent Application Number 16945124

Respondent Patent Number 11149306

External Links

Espacenet

Google Patents

Respondent Inventor AmirAli TALASAZ et al

Respondent Tech Center TC 1600 - Biotechnology & Organic Chemistry

Address and Attorney/Agent Information

64 Registered Practitioners

Power of Attorney & Correspondence

Firm / Entity Name Guardant Health, Inc. / WSGR

Customer Number 115823

Address 650 Page Mill Road, Palo Alto, CA, 94304, UNITED STATES

Attorney / Agent Information

Reg #	Name	Phone
34298	Scott Bortner	650-383-7237
34448	Richard Torczon Jr	202-973-8811
37505	Joe Liebeschuetz	650-838-2038
39666	Um Ping Eng	650-493-9300
44409	Karen Wong	650-493-9300
47664	Michael Hostetler	858-350-2306
52182	Michael Rosato	206-883-2529
52353	Lorelei Westin	858-350-2225
52505	Maya Skubatch	650-849-3330
54097	Andrew Finn	2033276401
54152	Ingo Hardt	858-350-2352
54196	Megan Jamroz	(651) 736-7586
59502	David Clark	858-350-2300
60302	Louis Lieto	202-973-8800
60629	Stephen Chen	213-629-6000
61063	Jeffrey Seidel	202-973-8838
61836	Matthew Argenti	650-493-9300
62407	Darby Chan	650-493-9300
62452	Matthew Bresnahan	858-350-2226
62554	Hin Meng Au	650-849-3064
65089	Christopher Mcandrew	617-598-7808
65119	Norman Hovijitra	650-493-9300
65256	Craig Kenesky	212-497-7767
66650	Laurie Mc Namara	858-350-2369
67024	Clark Lin	617-598-7823
67740	Timothy Hott	765-860-2617
67939	James Malecha	858-350-2300
68180	Ali Alemozafar	650-493-9300
68648	Deborah Smith	858-350-2315
68669	Julia Minitti	650-849-3042
68924	Rex Watkins	650-849-3144
68930	Bu Yin	858-677-1455
71594	Wesley Derryberry	202-973-8824
71901	Adam Cole	650-849-3298
72136	Ying Chen	617-598-7815
72267	Alicia Umpierre	858-350-2300
72550	Sara Patak	858-350-2302
72738	Jennifer Floyd	858-350-2267
72875	Celine Bonnefous	858-350-2213
73101	Matthew Wheeler	858-350-2317
73284	Scott Burkette	858-350-2234
73914	Rachna Ujwal	212-497-7741
74242	Bruce Kisliuk	301-580-6948
74394	Valentin Zunic	858-350-2211
74476	Indhu Kanakaraj	281-202-8334
74578	Eunhee Han	323-210-2908
74735	Patrick Medley	206-883-2593
74922	Eva Yin	206-883-2572
75021	Grant Margulieux	858-350-2356
75424	Sean Reed	858-350-2384
75546	Adrian Barker	415-730-6373
76067	Mengmeng Zhang	617-598-7814
76153	Tyler Baguley	858-350-2278
76285	Brandon Tavshanjian	415-947-2475
76474	Kelsey Macconaghy	415-471-3946
76486	Jing Wang	650-305-8774
76533	Dawson Wong	202-973-8940
76602	Garrett Potter	206-295-7363
76833	Katerina Otrubova	858-350-2216
76891	Swati Sharma	650-849-3055
76971	Payal Vyas	617-598-7842
77194	Madeline Elkins	650-849-3301
77907	Nicholas Tiee	650-849-3327
78717	Lauren Hodnett	617-598-7834

Proceeding Documents

192

Director Discretionary Decision: Deny RESPONSE

2025-12-18 FILING PARTY: BOARD

Download

3101

Email Correspondence Exhibit

2025-12-04 FILING PARTY: BOARD

Download

Patent Owner's Updated Exhibit List NOTICE

2025-12-01 FILING PARTY: PATENT OWNER

Download

2026

EX2026 - First Supplemental Preliminary Invalidity Contention Exhibit

2025-12-01 FILING PARTY: PATENT OWNER

Download

2025

EX2025 - Preliminary Invalidity Contentions Exhibit

2025-12-01 FILING PARTY: PATENT OWNER

Download

Tempus AI, Inc. vs. Guardant Health Inc.

Proceeding Overview

Parties & Counsel

Petitioner

Tempus AI, Inc.

Represented By

Patent Owner / Respondent

Guardant Health Inc.

Represented By

Tribunal & Venue

Patent Information

Address and Attorney/Agent Information

Power of Attorney & Correspondence

Attorney / Agent Information

Proceeding Documents

Director Discretionary Decision: Deny RESPONSE

Email Correspondence Exhibit

Patent Owner's Updated Exhibit List NOTICE

EX2026 - First Supplemental Preliminary Invalidity Contention Exhibit

EX2025 - Preliminary Invalidity Contentions Exhibit

EX2024 - Salk Nat Rev Genet 2018 Exhibit

Complaint in Guardant Health, Inc. v. Foundation Medicine, Inc., C.A. No. 17-cv-1616 Exhibit

EX2023 - Bae 2021 Exhibit

Complaint in Illumina, Inc. v. Guardant Health, Inc., C.A. No. 22-cv-334 Exhibit

Patent Owner's Preliminary Response POPR

Stipulation of Dismissal in Twinstrand Biosciences, Inc. v. Guardant Health, Inc., C.A. No. 21-cv-1126 Exhibit

Complaint in Guardant Health, Inc. v. Tempus AI, Inc., C.A. No. 24-cv-687 Exhibit

Petitioner's Opposition to PO Discretionary Denial Request RESPONSE

Scheduling Order in Guardant Health, Inc. v. Tempus AI, Inc., C.A. No. 24-cv-687 Exhibit

Petitioner's Stipulation OTHER

Patent Owner's Brief ISO Discretionary Denial. RESPONSE

EX2018 - FDA Approves First Liquid Biopsy Next-Generation Sequencing Companion Diagnostic Test. Exhibit

EX2021 - Guardant Health and Foundation Medicine Reach Settlement Exhibit

EX2017 - Guardant Health to showcase new data at ESMO 2022. Exhibit

EX2004 - 11211144 Exhibit

EX2001 - 11149306 Certified File Wrapper Exhibit

EX2015 - 2025.09.18 Tempus Proposed Claim Constructions. Exhibit

EX2016 - Guardant Health Introduces Major Smart Liquid Biopsy Upgrade Exhibit

EX2002 - Excerpt from EP20183626 Exhibit

EX2020 - Guardant Health Named to TIME100 Most Influential Companies. Exhibit

EX2003 - 17179279_06-28-2021_IDS Exhibit

EX2022 - 1_24-cv-00687 - First Amended Complaint Exhibit

EX2019 - GOZILA Study Published in Nature Medicine. Exhibit

Patent Owner's Power of Attorney NOTICE

Patent Owner's Mandatory Notices NOTICE

Quail et al., Improved protocols for the Illumina Genome Analyzer sequencing system, CURRENT PROTOCOLS IN HUMAN GENETICS 18.2.1-18.2.27 (2009) (Corrected) Exhibit

Guardant Health, Inc. v. University of Washington, IPR2022- 00816, Paper 3 – Petition for Inter Partes Review of U.S. Patent No. 10,760,127 (Corrected) Exhibit

Prosecution history for the ’306 patent (Corrected) Exhibit

Cibulskis et al., Sensitive detection of somatic point mutations in impure and heterogeneous cancer samples, NATURE BIOTECHNOLOGY 31:213–219 (2013) (Corrected) Exhibit

Meyerson et al., Advances in understanding cancer genomes through second-generation sequencing, NATURE REVIEWS GENETICS 11:685–696 (2010) (Corrected) Exhibit

McKenna et al., The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data, GENOME RESEARCH 20:1297-1303 (2010) (Corrected) Exhibit

Sharma et al., (TG/CA)n repeats in human gene families: abundance and selective patterns of distribution according to function and gene length, BMC GENOMICS 6:83 pp. 1–12 (2005) (Corrected) Exhibit

Tóth et al., Microsatellites in different eukaryotic genomes: Survey and analysis, GENOME RESEARCH 10:967–981 (2000) (Corrected) Exhibit

U.S. Patent No. 11,149,306 (Corrected) Exhibit

Gene changes and cancer, https://www.cancer.org/cancer/understanding-cancer/genesand- cancer/gene-changes.html (last visited July 30, 2025) (Corrected) Exhibit

Laghi et al., Differences and evolution of the methods for the assessment of microsatellite instability, ONCOGENE 27:6313– 6321 (Corrected) Exhibit

Danecek et al., The variant call format and VCFtools, BIOINFORMATICS 27:2156–2158 (2011) (Corrected) Exhibit

Cooper et al., Mutational and selective effects on copy-number variants in the human genome, NATURE GENETICS 39:S22–S29 (2007) (Corrected) Exhibit

Guardant Health, Inc. v. University of Washington, IPR2022- 00935, Paper 2 – Petition for Inter Partes Review of U.S. Patent No. 10,287,631 (Corrected) Exhibit

Metzker & Caskey, Polymerase Chain Reaction, In ENCYCLOPEDIA OF MEDICAL DEVICES AND INSTRUMENTATION, Second Edition, Volume 5 (2006) (Corrected) Exhibit

Bentley et al., Accurate whole human genome sequencing using reversible terminator chemistry, NATURE 456:53–59 (2008) (Corrected) Exhibit

Curriculum Vitae of Michael Metzker, Ph.D. (Corrected) Exhibit

DePristo et al., A framework for variation discovery and genotyping using next-generation DNA sequencing data, NATURE GENETICS 43:491–498 (2011) and Online Methods (Corrected) Exhibit

Glenn, Field guide to next-generation DNA sequencers, MOLECULAR ECOLOGY RESOURCES 11:759-769 (2011) (Corrected) Exhibit

Gnirke et al., Solution hybrid selection with ultra-long oligonucleotides for massively parallel targeted sequencing, NATURE BIOTECHNOLOGY 27:182–189 (2009) (Corrected) Exhibit

PCT Publication No. WO 2012/142213 A2 (Corrected) Exhibit

Cock et al., The Sanger FASTQ file format for sequences with quality scores, and the Solexa/Illumina FASTQ variants (Corrected) Exhibit

Guardant Health, Inc. v. University of Washington, IPR2022- 01388, Paper 2 – Petition for Inter Partes Review of U.S. Patent No. 10,689,699 (Corrected) Exhibit

Turner et al., Methods for genomic partitioning, ANNUAL REVIEW OF GENOMICS AND HUMAN GENETICS 10:263-284 (2009) (Corrected) Exhibit

U.S. Patent Application Publication No. 2011/0160078 (Corrected) Exhibit

Li et al., The sequence alignment/map format and SAMtools, BIOINFORMATICS 25:2078–2079 (2009) (Corrected) Exhibit

Edwards & Gibbs, Multiplex PCR: Advantages, development, and applications, GENOME RESEARCH 3:S65-S75 (1994) (Corrected) Exhibit

Fernández-Suárez & Galperin, The 2013 Nucleic Acids Research Database Issue and the online Molecular Biology Database Collection, Nucleic Acids Research 41:D1-D7 (2013) (Corrected) Exhibit

U.S. Patent No. 9,085,798 (Corrected) Exhibit

Hastings et al., Mechanisms of change in gene copy number, NATURE REVIEWS GENETICS 10:551–564 (2009) (Corrected) Exhibit

Forbes, et al., COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer, NUCLEIC ACIDS RESEARCH 39:D945–D950 (2011) (Corrected) Exhibit

PCT Publication No. WO 2012/099832 A2 (Corrected) Exhibit

Li & Durbin, Fast and accurate long-read alignment with Burrows–Wheeler transform, Bioinformatics 26: 589–595 (2010) (Corrected) Exhibit

Somatic & germline mutations, https://my.clevelandclinic.org/health/body/23067-somatic-- germline-mutations (Corrected) Exhibit

Richard & Pâques, Mini- and microsatellite expansions: the recombination connection, EMBO REPORTS 1:122–126 (2000) (Corrected) Exhibit