Merck Sharp & Dohme LLC vs. Halozyme, Inc. et al.

Explore the PTAB proceeding PGR2025-00017 filed by Merck Sharp & Dohme LLC on 2025-01-17. This includes filing dates, application numbers, tech centers, patent numbers, and current case status.

Proceeding Overview

Proceeding Number

PGR2025-00017

Filing Date

2025-01-17

Accorded Filing Date

2025-01-17

Institution Decision Date

2025-09-08

Last Modified Date

2026-10-09

Proceeding Type

PGR

Termination Date

2026-09-01

Trial Status

Pending Director Review

Parties & Counsel

Petitioner

Merck Sharp & Dohme LLC

Represented By

Kushan, Jeffreyet al

Patent Owner / Respondent

Halozyme, Inc. et al.

Represented By

Ellison, Eldoraet al

Tribunal & Venue

Tribunal

Patent Trial and Appeal Board (USPTO)

Technology Center

TC 1600 - Biotechnology & Organic Chemistry

Patent Information

1 Patent Involved

Respondent Application Number 18068418

Respondent Patent Number 12110520

External Links

Espacenet

Google Patents

Respondent Inventor Ge Wei et al

Respondent Tech Center TC 1600 - Biotechnology & Organic Chemistry

Address and Attorney/Agent Information

104 Registered Practitioners

Power of Attorney & Correspondence

Firm / Entity Name Morgan, Lewis & Bockius LLP (PH)

Customer Number 28977

Address 2222 Market Street, Philadelphia, PA, 19103, UNITED STATES

Attorney / Agent Information

Reg #	Name	Phone
31066	Gary Williams	650-843-7501
37386	Michael Lyons	650-843-7507
39266	Soyeon Laub	714-830-0512
39951	Douglas Crisman	650-843-4000
40506	Louis Beardell Jr	215-963-5067
41040	Robert Goodell	202-739-5549
41796	Andrew Gray Iv	650-843-4000
42223	Jason White	312-321-4200
42813	Brett Lovejoy	415-442-1211
42837	Jeffry Mann	415-442-1000
43378	Collin Park	202-739-3000
44146	Brent Hawkins	415-442-1000
45645	Dion Bregman	650-843-4000
46692	Ramyar Farid	202-739-5195
50801	Robert Smyth	202-739-5139
50862	Ahren Hsu-Hoffman	650-843-4000
50891	Jeffrey Killian	202-739-5592
51793	Mark Hayman	617-951-8440
53615	Nathan Smith	949-757-6018
55202	Jason Gettleman	650-843-7593
55293	Ari Indik	215-864-7138
56890	Christopher Betti	312-324-1449
57765	Yalei Sun	650-843-7558
58729	Louis-Vu Nguyen	415-442-1303
58752	John Hemmer	215-963-4816
59462	Brad Wilson	312-324-1103
59649	Tae Woong Koo	650-843-7246
60472	M. Hales	714-830-0514
60711	Richard Leung	215-963-5082
61841	Kenneth Cheney	714-830-0526
63115	Michael Ryan	610-574-1318
63133	Stephen Altieri	617-951-8525
63328	Clay Hawes	7034154864
64526	Janice Logan	202-439-5234
65210	Christina Macdougall	415-442-1277
65452	Kelly Plummer	312-324-1490
65592	Liying Sun	650-843-7215
66838	Jianbai Wang	650-843-7843
67084	Maria Doukas	312-324-1454
67908	Yingying Zhou	415-442-1214
67961	Tairan Wang	202-739-5119
68345	Danny Mansour	714-830-0600
68487	Alia Orbin	610-390-7234
69096	Toyomi Ohara	202-739-3000
69232	Rachna Ram	510-524-1579
69316	Byung Cheol Kwak	617-341-7264
69333	Hosang Lee	202-937-5142
70067	Sujohn Das	713-890-5792
70236	Kalpesh Upadhye	202-739-5157
70711	Benjamin Pezzner	650-843-4000
70871	Andrew Antczak	215-963-5000
71054	Yon Sohn	858-587-1121
71064	David Bernstein	650-843-4000
71076	Wan-Shoon Lo	312-984-5810
71397	Alexander Stein	650-843-7278
71751	Moreshwar Vaze	617-341-7952
71783	Nicholas Restauri	312-324-1000
72445	Jianke Kang	202-739-5183
73464	Hang Zheng	202-585-8307
73683	Amanda Williamson	312-324-1450
73696	Chantal Edde	215-963-5656
74139	Ka Lo Yeh	650-843-7815
74539	Sadie Knight	415-442-1000
74630	Victor Ghidu	215-963-5719
75253	Alyssa Pugh	215-963-5070
75470	Sara Sims	215-963-5630
75669	Andrew Dietrick	570-906-0745
75688	Emily Coury	617-341-7818
75724	Alexandra Koseva	650-843-7211
75810	Matthew Walker	206-274-6374
75815	Catherine Chou	650-843-4000
76003	Drew Bennett	617-341-7833
76140	Alexandria Petterson	650-843-7841
76203	Calvin Brien	202-739-5167
76671	Andrew Devkar	310-255-9070
77267	Ai Leen Koh	650-843-7823
77446	Theodore Rand	650-843-7275
77698	Phillip Wolfe	215-963-5454
77918	Alicia Fraind	215-972-8594
77996	Min Woo Park	202-673-95697
78072	Conor Ball	415-442-1668
78272	Sandhal Olds	765-618-4658
79029	Alexander Harrison	404-815-6046
79060	Kannan Narayanan	408-685-3658
79300	Evelyn Chou	415-442-1609
79663	Kathryn Chesnick	570-878-2384
79760	Xiaoqian Li	650-843-7853
79839	Peter Loderup	714-830-0517
79856	Timmy Lee	650-843-7517
80363	Yuqi Li	215-564-3236
80469	Alec Mandell	650-843-7228
80622	Corey Moore	617-341-7852
80944	Hye Hyun Ahn	202-434-7300
81040	Eunjean Je	202-739-5929
81210	Hayley Reed	215-963-4957
81433	Kurosu Altaf	650-843-7233
81482	Pablo Herrera Jr.	650-843-7512
81484	Samantha Kuo	714-579-5530
81604	Xinming Zhang	415-442-1392
81935	Jia Jie Tang	617-951-8000
81982	Corine Martineau	215-963-5030
82004	Isabella Couture	316-680-1931
82139	Xuedong Zhu	857-333-6217
82373	Alyssa Galvin	202-739-5786

Proceeding Documents

200

109

Authorized Response to Director Review Request OTHER

2026-10-09 FILING PARTY: PETITIONER

Download

3102

Ex. 3102 Counsel email for authorized response Exhibit

2026-10-02 FILING PARTY: BOARD

Download

108

Patent Owner's Request for Director Review REQUEST

2026-10-01 FILING PARTY: PATENT OWNER

Download

107

Other: Hearing transcript OTHER

2026-09-24 FILING PARTY: BOARD

Download

106

JUDGMENT Final Written Decision Determining All Challenged Claims Unpatentable 35 U.S.C. § 328(a) FINAL

2026-09-01 FILING PARTY: BOARD

Download

Merck Sharp & Dohme LLC vs. Halozyme, Inc. et al.

Proceeding Overview

Parties & Counsel

Petitioner

Merck Sharp & Dohme LLC

Represented By

Patent Owner / Respondent

Halozyme, Inc. et al.

Represented By

Tribunal & Venue

Patent Information

Address and Attorney/Agent Information

Power of Attorney & Correspondence

Attorney / Agent Information

Proceeding Documents

Authorized Response to Director Review Request OTHER

Ex. 3102 Counsel email for authorized response Exhibit

Patent Owner's Request for Director Review REQUEST

Other: Hearing transcript OTHER

JUDGMENT Final Written Decision Determining All Challenged Claims Unpatentable 35 U.S.C. § 328(a) FINAL

MSD LLC v. Halozyme - Petitioner Demonstratives (Part 4 Slides 131-194) Exhibit

MSD LLC v. Halozyme - Petitioner Demonstratives (Part 3 Slides 66-130) Exhibit

MSD LLC v. Halozyme - Petitioner Demonstratives (Part 2 Slides 51-65) Exhibit

Petitioner Demonstratives OTHER

MSD LLC v. Halozyme - Petitioner Demonstratives (Part 1 Slides 1-50) Exhibit

Patent Owner's Updated Exhibit List NOTICE

EX2500 - Patent Owner's Demonstratives for Oral Argument Exhibit

Patent Owner's Updated Mandatory Notices NOTICE

Email_Request for DR Denying PO's Motion to Terminate_Dismissed Exhibit

Patent Owner's Request for Director Review of Order Denying Motion to Terminate (PUBLIC - REDACTED) OTHER

Patent Owner's Updated Mandatory Notices NOTICE

EX2303 - PGR2025-00046 EX1133 - Naismith Declaration Exhibit

EX2301 - Naismith Deposition Transcript Exhibit

Patent Owner's Sur-Reply OTHER

EX2215 - Khurana 2011 Exhibit

EX2300 - Naismith Declaration Errata Exhibit

EX2302 - Kelsoe Deposition Transcript Exhibit

Email, Subject_Merck v. Halozyme PGRs __ Filing of Request for Director Review Exhibit

Deposition Transcript of Kelly Grez Exhibit

Patent Owner's Brief on Testimony of Ms. Kelly Grez (PUBLIC - UPDATED REDACTIONS) OTHER

Public Order Denying Motion to Terminate OTHER

Patent Owner's Sixth Motion to Seal MOTION

Order: Granting PO's Motion to Seal ORDER

ORDER Granting Petitioner’s Motion to Seal 37 C.F.R. §§ 42.14, 42.54 ORDER

Order: ORDER Setting Oral Argument 37 C.F.R. § 42.70 ORDER

Patent Owner's Notice of Intent to Designate Provisionally Recognized PTAB Attorney as Back-up Counsel NOTICE

Patent Owner's Updated Exhibit List NOTICE

Patent Owner's Updated Mandatory Notices NOTICE

EX2214 - Summers PTAB Declaration Exhibit

Patent Owner's Updated Power of Attorney NOTICE

Corrected Declaration of James Naismith, Ph.D. Exhibit

Patent Owner's Objections to Evidence OTHER

Petitioner's Request for Oral Argument OTHER

Patent Owner's Request for Oral Argument OTHER

Csoka, A. et al., “The Six Hyaluronidase-Like Genes in the Human and Mouse Genomes” Matrix Biology 20:499-508 (2001) Exhibit

Fauci, A. et al., “The Relationship between Antibody Affinity and the Efficiency of Complement Fixation,” J Immunol., 105(1):215-20 (1970) Exhibit

2024 Chemistry Nobel Prize Background Exhibit

Lu, X. et al., “Anti-gp160 IgG and IgA Antibodies Associated with a Large Increase in Total IgG in Cervicovaginal Secretions from Human Immunodeficiency Virus Type l-Infected Women,” Journal of Infectious Disease, 167(5):1189-92 (1993) Exhibit

Wang et al., “Immunogenicity of protein aggregates-Concerns and Realities” Int. J. Pharmaceutics 431:1-11, (2012) Exhibit

Dobson, “Experimental investigation of protein folding and misfolding” Methods 34(1):4-14 (2004) Exhibit

Ochoa-Levya et al., “Protein Design through Systematic Catalytic Loop Exchange in the (beta/alpha)8 Fold” J. Mol. Biol. 10 387(4):949-64 (2009) Exhibit

Nelson, C. et al., “Peptides Determine the Lifespan of MHC Class II Molecules in the Antigen-Presenting Cell,” Nature, 371(6494):250-2 (1994) Exhibit

Melanie Ann Simpson, Ph.D. Deposition Transcript Exhibit

Petitioner's Reply REPLYTOOPP

Transcript of the Deposition of Dr. Gary Cherr, Ph.D., November 12, 2025 Exhibit

Im, S. et al., “Cryo-EM Structure of Human Hyaluronidase PH-20,” Proteins: Structure, Function, and Bioinformatics 93:1067-1073 (2025) Exhibit

Dobson, “Protein folding and misfolding” Nature. 18;426(6968):884-90 (2003) Exhibit

Declaration of Dr. Garnett Kelsoe Exhibit

Redwood, A. et al., “Viral Vectored Immunocontraception: Screening of Multiple Fertility Antigens using Murine Cytomegalovirus as a Vaccine Vector,” Vaccine, 25(4):698-708 (2007) Exhibit

Singh, S., et al., “Solubilization and Refolding of Bacterial Inclusion Body Proteins,” Journal of Bioscience and Bioengineering 99:303-310 (2005) Exhibit

Gregory Petsko, Ph.D. Deposition Transcript Exhibit

Rodriguez, L. et al., “Foot and mouth disease virus vaccines,” Vaccine 27:D90-D94 (2009) Exhibit

Chiti & Dobson, “Protein Misfolding, Functional Amyloid, and Human Disease” Annu. Rev. Biochem. 75:333–66 (2006) Exhibit

Rolland, M. et al., “Recognition of HIV-1 Peptides by Host CTL Is Related to HIV-1 Similarity to Human Proteins,” PLoS One, 2(9):e823 (2007) Exhibit

Levine, B. and Levytska, V., “A Sensitive Hemagglutination Assay Method for Dinitrophenyl-Specific Antibodies. The Effect of Antibody Binding Affinity on Titers,” J Immunol., 98(3):648-52 (1967) Exhibit

Chiti et al., “Rationalization of the effects of mutations on peptide and protein aggregation rates” Nature, 424:805-808 (2003) Exhibit

Poelwijk, Frank J., et al., “Empirical fitness landscapes reveal accessible evolutionary paths” Nature 445.7126 (2007): 383-386 Exhibit

Printz, M. et al., “Risk Factors, Hyaluronidase Expression, and Clinical Immunogenicity of Recombinant Human Hyaluronidase PH20, an Enzyme Enabling Subcutaneous Drug Administration,” AAPS 24(6):110 (2022) Exhibit

Yewdell, J. et al., “Immunodominance in Major Histocompatibility Complex Class I-restricted T Lymphocyte Responses,” Annu. Rev. Immunol., 17:51–88 (1999) Exhibit

Gershoni, J. et al., “Epitope Mapping: The First Step in Developing Epitope-Based Vaccines,” BioDrugs, 21(3):145-56 (2007) Exhibit