Merck Sharp & Dohme LLC vs. Halozyme, Inc. et al.

Explore the PTAB proceeding PGR2025-00024 filed by Merck Sharp & Dohme LLC on 2025-02-21. This includes filing dates, application numbers, tech centers, patent numbers, and current case status.

Proceeding Overview

Proceeding Number

PGR2025-00024

Filing Date

2025-02-21

Accorded Filing Date

2025-02-21

Institution Decision Date

2025-10-16

Last Modified Date

2026-10-15

Proceeding Type

PGR

Termination Date

2026-10-15

Trial Status

Final Written Decision

Parties & Counsel

Petitioner

Merck Sharp & Dohme LLC

Represented By

Kushan, Jeffreyet al

Patent Owner / Respondent

Halozyme, Inc. et al.

Represented By

Ellison, Eldoraet al

Tribunal & Venue

Tribunal

Patent Trial and Appeal Board (USPTO)

Technology Center

TC 1600 - Biotechnology & Organic Chemistry

Patent Information

1 Patent Involved

Respondent Application Number 18068218

Respondent Patent Number 12060590

External Links

Espacenet

Google Patents

Respondent Inventor Ge WEI et al

Respondent Tech Center TC 1600 - Biotechnology & Organic Chemistry

Address and Attorney/Agent Information

104 Registered Practitioners

Power of Attorney & Correspondence

Firm / Entity Name Morgan, Lewis & Bockius LLP (PH)

Customer Number 28977

Address 2222 Market Street, Philadelphia, PA, 19103, UNITED STATES

Attorney / Agent Information

Reg #	Name	Phone
31066	Gary Williams	650-843-7501
37386	Michael Lyons	650-843-7507
39266	Soyeon Laub	714-830-0512
39951	Douglas Crisman	650-843-4000
40506	Louis Beardell Jr	215-963-5067
41040	Robert Goodell	202-739-5549
41796	Andrew Gray Iv	650-843-4000
42223	Jason White	312-321-4200
42813	Brett Lovejoy	415-442-1211
42837	Jeffry Mann	415-442-1000
43378	Collin Park	202-739-3000
44146	Brent Hawkins	415-442-1000
45645	Dion Bregman	650-843-4000
46692	Ramyar Farid	202-739-5195
50801	Robert Smyth	202-739-5139
50862	Ahren Hsu-Hoffman	650-843-4000
50891	Jeffrey Killian	202-739-5592
51793	Mark Hayman	617-951-8440
53615	Nathan Smith	949-757-6018
55202	Jason Gettleman	650-843-7593
55293	Ari Indik	215-864-7138
56890	Christopher Betti	312-324-1449
57765	Yalei Sun	650-843-7558
58729	Louis-Vu Nguyen	415-442-1303
58752	John Hemmer	215-963-4816
59462	Brad Wilson	312-324-1103
59649	Tae Woong Koo	650-843-7246
60472	M. Hales	714-830-0514
60711	Richard Leung	215-963-5082
61841	Kenneth Cheney	714-830-0526
63115	Michael Ryan	610-574-1318
63133	Stephen Altieri	617-951-8525
63328	Clay Hawes	7034154864
64526	Janice Logan	202-439-5234
65210	Christina Macdougall	415-442-1277
65452	Kelly Plummer	312-324-1490
65592	Liying Sun	650-843-7215
66838	Jianbai Wang	650-843-7843
67084	Maria Doukas	312-324-1454
67908	Yingying Zhou	415-442-1214
67961	Tairan Wang	202-739-5119
68345	Danny Mansour	714-830-0600
68487	Alia Orbin	610-390-7234
69096	Toyomi Ohara	202-739-3000
69232	Rachna Ram	510-524-1579
69316	Byung Cheol Kwak	617-341-7264
69333	Hosang Lee	202-937-5142
70067	Sujohn Das	713-890-5792
70236	Kalpesh Upadhye	202-739-5157
70711	Benjamin Pezzner	650-843-4000
70871	Andrew Antczak	215-963-5000
71054	Yon Sohn	858-587-1121
71064	David Bernstein	650-843-4000
71076	Wan-Shoon Lo	312-984-5810
71397	Alexander Stein	650-843-7278
71751	Moreshwar Vaze	617-341-7952
71783	Nicholas Restauri	312-324-1000
72445	Jianke Kang	202-739-5183
73464	Hang Zheng	202-585-8307
73683	Amanda Williamson	312-324-1450
73696	Chantal Edde	215-963-5656
74139	Ka Lo Yeh	650-843-7815
74539	Sadie Knight	415-442-1000
74630	Victor Ghidu	215-963-5719
75253	Alyssa Pugh	215-963-5070
75470	Sara Sims	215-963-5630
75669	Andrew Dietrick	570-906-0745
75688	Emily Coury	617-341-7818
75724	Alexandra Koseva	650-843-7211
75810	Matthew Walker	206-274-6374
75815	Catherine Chou	650-843-4000
76003	Drew Bennett	617-341-7833
76140	Alexandria Petterson	650-843-7841
76203	Calvin Brien	202-739-5167
76671	Andrew Devkar	310-255-9070
77267	Ai Leen Koh	650-843-7823
77446	Theodore Rand	650-843-7275
77698	Phillip Wolfe	215-963-5454
77918	Alicia Fraind	215-972-8594
77996	Min Woo Park	202-673-95697
78072	Conor Ball	415-442-1668
78272	Sandhal Olds	765-618-4658
79029	Alexander Harrison	404-815-6046
79060	Kannan Narayanan	408-685-3658
79300	Evelyn Chou	415-442-1609
79663	Kathryn Chesnick	570-878-2384
79760	Xiaoqian Li	650-843-7853
79839	Peter Loderup	714-830-0517
79856	Timmy Lee	650-843-7517
80363	Yuqi Li	215-564-3236
80469	Alec Mandell	650-843-7228
80622	Corey Moore	617-341-7852
80944	Hye Hyun Ahn	202-434-7300
81040	Eunjean Je	202-739-5929
81210	Hayley Reed	215-963-4957
81433	Kurosu Altaf	650-843-7233
81482	Pablo Herrera Jr.	650-843-7512
81484	Samantha Kuo	714-579-5530
81604	Xinming Zhang	415-442-1392
81935	Jia Jie Tang	617-951-8000
81982	Corine Martineau	215-963-5030
82004	Isabella Couture	316-680-1931
82139	Xuedong Zhu	857-333-6217
82373	Alyssa Galvin	202-739-5786

Proceeding Documents

200

100

Final Written Decision: original FINAL

2026-10-15 FILING PARTY: BOARD

Download

Other: Hearing transcript OTHER

2026-09-24 FILING PARTY: BOARD

Download

1278

MSD LLC v. Halozyme - Petitioner Demonstratives (Part 4 Slides 131-194) Exhibit

2026-07-20 FILING PARTY: PETITIONER

Download

1278

MSD LLC v. Halozyme - Petitioner Demonstratives (Part 2 Slides 51-65) Exhibit

2026-07-20 FILING PARTY: PETITIONER

Download

1278

MSD LLC v. Halozyme - Petitioner Demonstratives (Part 3 Slides 66-130) Exhibit

2026-07-20 FILING PARTY: PETITIONER

Download

Merck Sharp & Dohme LLC vs. Halozyme, Inc. et al.

Proceeding Overview

Parties & Counsel

Petitioner

Merck Sharp & Dohme LLC

Represented By

Patent Owner / Respondent

Halozyme, Inc. et al.

Represented By

Tribunal & Venue

Patent Information

Address and Attorney/Agent Information

Power of Attorney & Correspondence

Attorney / Agent Information

Proceeding Documents

Final Written Decision: original FINAL

Other: Hearing transcript OTHER

MSD LLC v. Halozyme - Petitioner Demonstratives (Part 4 Slides 131-194) Exhibit

MSD LLC v. Halozyme - Petitioner Demonstratives (Part 2 Slides 51-65) Exhibit

MSD LLC v. Halozyme - Petitioner Demonstratives (Part 3 Slides 66-130) Exhibit

MSD LLC v. Halozyme - Petitioner Demonstratives (Part 1 Slides 1-50) Exhibit

Petitioner's Updated Exhibit List NOTICE

Patent Owner's Updated Mandatory Notices NOTICE

EX2500 - Patent Owner's Demonstratives for Oral Argument Exhibit

Patent Owner's Updated Exhibit List NOTICE

Email_Request for DR Denying PO's Motion to Terminate_Dismissed Exhibit

EX2300 - Naismith Declaration Errata Exhibit

EX2302 - Kelsoe Deposition Transcript Exhibit

EX2301 - Naismith Deposition Transcript Exhibit

Patent Owner's Sur-Reply OTHER

EX2215 - Khurana 2011 Exhibit

EX2304 - Naismith Deposition Transcript 2026-06-13 Exhibit

EX2303 - PGR2025-00046 EX1133 - Naismith Declaration Exhibit

Patent Owner's Request for Director Review of Order Denying Motion to Terminate (PUBLIC - REDACTED) OTHER

Patent Owner's Updated Mandatory Notices NOTICE

Email, Subject_Merck v. Halozyme PGRs __ Filing of Request for Director Review Exhibit

Deposition Transcript of Kelly Grez Exhibit

Patent Owner's Brief on Testimony of Ms. Kelly Grez (PUBLIC - UPDATED REDACTIONS) OTHER

Public Order Denying Motion to Terminate OTHER

Patent Owner's Sixth Motion to Seal MOTION

ORDER Granting Petitioner’s Motion to Seal 37 C.F.R. §§ 42.14, 42.54 ORDER

Order: Conditionally Granting PO's Motion to Seal ORDER

Order: ORDER Setting Oral Argument 37 C.F.R. § 42.70 ORDER

Patent Owner's Objections to Evidence OTHER

EX2214 - Summers PTAB Declaration Exhibit

Patent Owner's Updated Mandatory Notices NOTICE

Patent Owner's Updated Power of Attorney NOTICE

Patent Owner's Notice of Intent to Designate Provisionally Recognized PTAB Attorney as Back-up Counsel NOTICE

Patent Owner's Updated Exhibit List NOTICE

Primakoff, P. et al., “Purification of the guinea pig sperm PH-20 antigen and detection of a site-specific endoproteolytic activity in sperm preparations that cleaves PH-20 into two disulfide-linked fragments,” Biology of Reproduction 38:921-934 (1988) Exhibit

Chiti et al., “Studies of aggregation of mutant proteins in vitro provided insights into genetics of amyloid diseases” PNAS 99:16419-26 (2002) Exhibit

Van Rossum et al., “Reporter-based screening and selection of enzymes” FEBS J. 280:2979-96 (2013) Exhibit

Nikolova E. et al., “All Forms of Human IgA Antibodies Bound to Antigen Interfere with Complement (C3) Fixation Induced by IgG or by Antigen Alone,” Scand J Immunol., 39(3):275-80 (1994) Exhibit

Wang et al., “Immunogenicity of protein aggregates-Concerns and Realities” Int. J. Pharmaceutics 431:1-11, (2012) Exhibit

Li, M. et al., “Importance of Glycosylation and Disulfide Bonds in Hyaluronidase Activity of Macaque Sperm Surface PH-20,” J Androl., 23(2):211-9 (2002) Exhibit

Reed et al., “Use of Coefficient of Variation in Assessing Variability of Quantitative Assays” Clin. Diagn. Lab Immunol. 9(6):1235-9 (2002) Exhibit

Murphy, K., “Janeway’s Immuno Biology,” (8th 2012), Chapters 1, 4, 8, 10, 11, 12, 15, and Appx I (Part 1) Exhibit

2024 Chemistry Nobel Prize Background Exhibit

Declaration of Jeffrey P. Kushan (Petitioner's Reply) Exhibit

Declaration of James Naismith, Ph.D. Exhibit

Fowler et al., “High-resolution mapping of protein sequence-function relationships” Nature Methods 7, 741–746 (2010) Exhibit

Cherr, G. et al., “The Dual Functions of GPI-Anchored PH-20: Hyaluronidase and Intracellular Signaling,” Matrix Biol., 20(8):515-25 (2001) Exhibit

Gregory Petsko, Ph.D. Deposition Transcript Exhibit

Gershoni, J. et al., “Epitope Mapping: The First Step in Developing Epitope-Based Vaccines,” BioDrugs, 21(3):145-56 (2007) Exhibit

Bolland, S., “An Innate Path to Human B Cell Tolerance,” Immunity, 29(5):667-9 (2008) Exhibit

Rolland, M. et al., “Recognition of HIV-1 Peptides by Host CTL Is Related to HIV-1 Similarity to Human Proteins,” PLoS One, 2(9):e823 (2007) Exhibit

Goodey, N. et al., “Allosteric Regulation and Catalysis Emerge via a Common Route,” Nat Chem Biol. 4(8):474-82 (2008) Exhibit

Ringe & Petsko, “Q&A: What are pharmacological chaperones and why are they interesting?” J. Biol. 8:80 (2009) Exhibit

Hirsch, C. et al., “The Ubiquitylation Machinery of the Endoplasmic Reticulum,” Nature, 458(7237):453-60 (2009) Exhibit

Martin-Deleon, “Epididymal SPAM1 and its Impact on Sperm Function” Molecular and Cellular Endocrinology 250:114-121 (2006) Exhibit

Dobson, “Experimental investigation of protein folding and misfolding” Methods 34(1):4-14 (2004) Exhibit

Ten Have et al., “Cloning and characterization of the cDNA encoding the PH20 protein in the European red fox Vulpes vulpes” Reprod. Fertil. Dev. 10(2):165-72 (1998) Exhibit

Dr. Naismith Analysis Spreadsheet Exhibit

Levine, B. and Levytska, V., “A Sensitive Hemagglutination Assay Method for Dinitrophenyl-Specific Antibodies. The Effect of Antibody Binding Affinity on Titers,” J Immunol., 98(3):648-52 (1967) Exhibit

Anderson, M. et al., “Projection of an Immunological Self Shadow Within the Thymus by the Aire Protein,” Science, 298(5597):1395-401 (2002) Exhibit

Csoka, A. et al., “The Six Hyaluronidase-Like Genes in the Human and Mouse Genomes” Matrix Biology 20:499-508 (2001) Exhibit

Murphy, K., “Janeway’s Immuno Biology,” (8th 2012), Chapters 1, 4, 8, 10, 11, 12, 15, and Appx I (Part 2) Exhibit

Dobson, “Principles of protein folding, misfolding and aggregation” Semin. Cell. Dev. Biol. 15(1):3-16 (2004) Exhibit

Calloni et al., “Investigating the Effects of Mutations on Protein Aggregation in the Cell” J. Biol. Chem. 10607-13 (2005) Exhibit

Dunn, C. et al., “Transcription of the Human and Rodent SPAM1 / PH-20 Genes Initiates Within an Ancient Endogenous Retrovirus,” BMC Genomics, 6:47 (2005) Exhibit